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Probiotic supplement shows promise for gout prevention in small study

NCT ID NCT06969469

Disease control Sponsor: Grape King Bio Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study tested whether a probiotic supplement called LUA Probiotics can lower uric acid levels in the blood. Twenty adults with high uric acid or gout who were not taking uric acid-lowering drugs took the supplement daily for 28 days. Researchers measured uric acid and other health markers at the start, after 2 weeks, and after 6 weeks to see if the probiotics made a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
LUA probiotics (Lactobacillus reuteri, beta-carotene, silicon dioxide, magnesium stearate)
What this could lead to
If it works, this could point toward a dietary supplement to help lower uric acid and reduce gout flare-ups, possibly decreasing the need for medication.
What could go wrong
This is a very small, early-stage study with only 20 participants. Results may not apply to everyone, and the supplement is not yet proven effective or commercially available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

20 people

The number who actually took part.

Started

Jul 2022

Finished

Aug 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

1. Collect 20 people, both male and female, aged 20 or above. 2. Be conscious, willing to participate in the clinical observational research project, and complete the signed written consent form. 3. Patients with hyperuricemia (uric acid level above 7.5 mg/dL) who have not taken uric acid-lowering drugs, and patients with gout who have not taken uric acid-lowering drugs, regardless of gender.

Ages

20 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Collect 20 people, both male and female, aged 20 or above. 2. Be conscious, willing to participate in the clinical observational research project, and complete the signed written consent form. 3. Patients with hyperuricemia (uric acid level above 7.5 mg/dL) who have not taken uric acid-lowering drugs, and patients with gout who have not taken uric acid-lowering drugs, regardless of gender. Exclusion Criteria: 1. Patients diagnosed by a physician as suffering from a major injury or illness listed by the National Health Insurance Administration. 2. Pregnant women or women who plan to become pregnant within six months. 3. Patients with abnormal liver function (AST, ALT greater than 2 times the upper limit of normal). 4. Patients with abnormal renal function (serum creatinine \> 1.5 mg/dL). 5. Patients with gastrointestinal dysfunction (surgery, frequent diarrhea). 6. Those who must continue to take antibiotics, histamine-2 antagonists, proton pump inhibitors, antioxidants, probiotics, laxatives and other drugs. 7. Patients with serious complications such as stroke, myocardial infarction, or major trauma or surgery in the past six months. 8. People who are allergic to Lactobacillus. 9. Subjects who are unable to exercise their right to consent on their own. 10. Those who have irregular eating habits and are unable to cooperate with the plan implementation. 11. Those who have poor compliance with doctor's orders.

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Conditions

The condition(s) this trial relates to.

gout

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gout

Contacts and locations

Locations

  • National Taiwan University Hospital

    Taipei, 100229, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.