GLIOBLASTOMA (GBM)

This early-phase study tests a new treatment for newly diagnosed glioblastoma, a fast-growing brain cancer. After standard surgery, patients receive an injection of donor stem cells that carry a 'suicide gene' directly into the brain. The goal is to see if this approach is safe a…

This trial tests a new gene therapy called TGX-007 for people with a fast-growing brain cancer called glioblastoma. The therapy uses a harmless virus to deliver two special instructions into the tumor: one helps a common antiviral drug kill cancer cells, and the other wakes up th…

This study tests whether adding a chemotherapy drug (thiotepa) directly into the spinal fluid can prevent the spread of glioblastoma, a fast-growing brain cancer, in patients at high risk. About 38 adults with newly diagnosed glioblastoma will receive the standard treatment plus …

This study tests whether a higher daily dose of radiation over three weeks can help older adults (65+) with newly diagnosed glioblastoma live longer and with fewer side effects compared to the standard dose. About 56 participants will be randomly assigned to one of two radiation …

This early-phase study tests a new treatment for a fast-growing brain cancer called glioblastoma. It combines a patient's own immune cells, specially trained to attack the cancer, with low-intensity ultrasound to temporarily open the blood-brain barrier, allowing more cells to re…

This early-phase trial tests an investigational drug (GSK5764227) that targets a protein called B7-H3 found on some brain tumor cells. It will enroll 15 people with recurrent grade 4 glioma or brain metastases from other cancers. The study first measures how much drug reaches the…

This study tests a new treatment using natural killer (NK) cells, a type of immune cell, to fight malignant brain tumors in adults who have not responded to standard therapies. The NK cells are given both into the brain and through a vein to see if they are safe and can shrink tu…

This study tests a new way of giving radiation therapy to people with glioblastoma, a fast-growing brain tumor. The approach uses daily MRI scans to precisely target the tumor with smaller margins, potentially reducing damage to healthy brain tissue. Researchers want to see if th…

This study tests whether adding an experimental drug called silevertinib to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer growing. The trial is for patients whose tumors have certain genetic…

This study tests a virus that targets cancer cells in people whose glioblastoma has returned after standard treatments. Twenty participants will receive up to six injections directly into the tumor over several weeks. The goal is to see if the virus is safe and can help control t…

This study tests a new drug called MT-125 given together with standard radiation for people newly diagnosed with a fast-growing brain tumor called glioblastoma. The main goals are to find a safe dose and understand side effects. Up to 36 adults will take part, and this is the fir…

This study tests a new drug called TLX101-Tx, which delivers targeted radiation directly to brain cancer cells, combined with standard chemotherapy (lomustine) in adults whose glioblastoma has returned after initial treatment. The goal is to see if the combination helps control t…

This study tests whether adding a new immune cell treatment (DOC1021) to standard therapy can help people with a newly diagnosed aggressive brain cancer called glioblastoma live longer. About 180 adults will be randomly assigned to receive either standard care alone or standard c…

This study tests whether giving G-CSF (a drug that boosts white blood cells) during standard chemoradiation can help preserve brain structure and thinking abilities in people with a specific type of glioblastoma (MGMT-methylated). About 60 newly diagnosed patients will be randoml…

This study tests a new treatment for aggressive brain tumors (glioblastoma) that uses a radioactive substance attached to a targeting molecule to deliver radiation directly to cancer cells. It is for 35 adults aged 18-80 who have already had standard treatments like surgery, radi…

This study is for people with a newly diagnosed, aggressive brain cancer called glioblastoma that has a specific genetic change (MTAP deletion). The trial tests an experimental drug, BGB-58067, designed to target cancer cells while sparing healthy ones. The goal is to see if the …

This study tests a combination of two drugs—Lutathera (a targeted radiation therapy) and olaparib (a PARP inhibitor)—in children and teens aged 3 to 18 with solid tumors that have come back or not responded to standard treatment. The goal is to find the safest dose and see if the…

This study tests whether adding a chemotherapy drug (thiotepa) injected into the spinal fluid can improve outcomes for people with glioblastoma that has spread to the brain's lining or fluid spaces. About 38 adults will receive surgery, radiation, and standard oral chemo plus the…

This study looks at whether taking the chemotherapy drug temozolomide at a specific time of day (morning vs evening) helps people with a type of brain cancer called glioblastoma. About 50 adults who have already had surgery and radiation will be randomly assigned to take their ch…

This study looks at mental health and suicide risk in people with glioblastoma, a serious brain cancer. Researchers will use questionnaires to track depression, anxiety, and quality of life in 176 patients across Germany. The goal is to find what factors increase suicide risk so …

This study is testing a program called FearLess to see if it helps people with brain tumors and their caregivers deal with the fear of the cancer coming back. The researchers want to find out if the study methods work well, including how they recruit participants and keep them in…

This study is developing a blood test that uses artificial intelligence to spot cancer early and see how well treatments are working. Researchers will analyze blood samples from 6000 adults with or without cancer to find unique signals in platelets and immune cells. The goal is a…

This study is testing whether a blood or urine test can detect signals from brain tumors, especially glioblastoma. Researchers will use a special dye (5-ALA) that makes tumor cells glow during surgery to help link what's seen in the blood to the actual tumor. The goal is to devel…