GLIOBLASTOMA (GBM)

This early-stage study tests a new drug called FZ-AD005 in about 40 people with aggressive brain tumors (high-grade glioma) that have come back or not responded to treatment. The drug is designed to deliver a cancer-killing agent directly to tumor cells. The main goals are to fin…

This early-phase trial tests a new treatment for recurrent glioblastoma, an aggressive brain cancer. The therapy uses a patient's own immune cells, engineered to better target and attack cancer cells. The study aims to see if this approach is safe and shows early signs of shrinki…

This early-phase trial tests a new drug (STAR-001) combined with spironolactone in about 68 adults whose glioblastoma has returned after initial treatment. The goal is to see if the combination is safe and can shrink tumors. Participants receive STAR-001 by IV twice per cycle and…

This study tests whether using a smaller radiation target area after glioblastoma surgery can still control the tumor while causing fewer side effects. About 79 adults aged 18-70 who had surgery for glioblastoma will receive radiation to a 1 cm margin around the original tumor, p…

This study tests a new way to give radiation therapy to people under 70 with a fast-growing brain tumor called glioblastoma. Instead of many small doses, patients get fewer but stronger doses of radiation along with the chemotherapy drug temozolomide. The goal is to see if this s…

This study tests whether adding a shingles vaccine and special immune cells (CMV-specific T cells) to standard surgery, radiation, and chemotherapy can help people with glioblastoma live longer. About 230 adults will take part. The goal is to improve tumor control and survival.

This study tests a stepped-care program to support relatives of people with serious brain diseases or injuries. 160 relatives will either receive the program or usual care. The goal is to reduce caregiver burden and improve well-being.

This study tests a special microscope attachment (GLOW400) that helps surgeons see glowing brain tumors during surgery. About 37 adults with suspected high-grade gliomas will take part. Surgeons will rate how well the tool shows the tumor and brain structures. The goal is to conf…

This study looks at how male hormones (androgens) influence the immune cells around glioblastoma, the most aggressive brain cancer. Researchers will analyze tumor and blood samples from 40 men and women aged 18-55 with newly diagnosed glioblastoma. The goal is to understand why m…