EPENDYMOMA

This study tests a cancer vaccine called SurVaxM in 35 children whose brain tumors have come back or are hard to treat. The vaccine teaches the immune system to find and destroy tumor cells. The goal is to see if it is safe and helps control the disease.

This study tests a single injection of a virus (DNX-2401) directly into brain tumors in children and young adults whose cancer has come back or not responded to treatment. The goal is to see if the virus can shrink tumors and help patients live longer. 39 participants will receiv…

This early-phase trial tests whether giving children with recurrent high-grade glioma a special type of stem cell treatment along with the immunotherapy drug nivolumab is safe and possible. The study involves 12 children whose brain tumors have come back after standard treatments…

This early-stage study tests a treatment called HER2 CAR T cells in up to 50 children whose ependymoma brain tumor has come back or not responded to standard care. The cells are made from each child's own blood and trained to recognize and attack the tumor. The main goals are to …

This study tests two immunotherapy drugs, cobolimab and dostarlimab, together in children and young adults (up to age 21) with advanced solid tumors that have not responded to other treatments. The goal is to find the safest dose and see if the combination can shrink tumors. The …

This early-phase trial tests whether specially engineered immune cells (IL13Rα2-CAR T cells) can safely target and destroy brain tumor cells that have spread to the lining of the brain and spinal cord. Ten adults with glioblastoma, ependymoma, or medulloblastoma will receive thes…

This early-phase study tests a genetically engineered virus (rQNestin34.5v.2) that targets and kills brain tumor cells. About 62 adults with recurrent malignant glioma will receive the virus injected directly into the tumor, sometimes with a drug called cyclophosphamide to boost …

This study tests a drug called indoximod, which aims to help the immune system fight brain tumors. It is for children aged 3 to 21 with certain types of progressive brain cancer or a newly diagnosed brainstem tumor (DIPG). Participants receive indoximod alongside standard chemoth…

This study looks at whether a wearable device called Optune is safe and practical for children with aggressive brain tumors. In one group, kids with recurrent high-grade glioma or ependymoma use the device alone. In another group, children with newly diagnosed DIPG use the device…

This study tests whether surgery followed by a second course of radiation can help children and young adults (ages 1-21) whose ependymoma brain tumor has returned after initial treatment. The combined radiation dose is higher than usual, and researchers will closely monitor side …

This early-stage study tests whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with HER2-positive brain tumors that have come back or not responded to standard treatments. The cells are…

This study looks at whether a special PET scan using a natural amino acid called methionine can help doctors see tumors in children and young adults with cancer. About 500 participants will get the scan to check if it can find tumors at diagnosis and tell the difference between a…