EPENDYMOMA

This study tests a drug called PLX038 in adults with brain or spinal cord tumors, especially those with changes in the MYC or MYCN genes. The goal is to see if the drug can shrink tumors or slow their growth. Participants receive the drug through an IV every 3 weeks and are follo…

This early-phase study tests whether a personalized immune cell treatment is safe for children under 5 with certain brain tumors. The treatment uses the child's own immune cells, trained to attack unique markers from their tumor. Up to 12 children will receive the therapy after s…

This early-stage trial tests whether adding the drug ibrutinib to a chemotherapy and immunotherapy combination can help children and young adults (ages 6–25) with brain cancers that have come back or not responded to standard treatment. The study aims to find the safest dose of i…

This early-stage study tests a new treatment for children and young adults (up to age 21) with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified to target a protein called B7-H3 on tumor cell…

This early-phase study tests an oral drug called ONC206 in 102 adults with brain tumors that have come back or are rare. The main goal is to find the safest dose and understand side effects. Participants take the drug by mouth on a weekly schedule, and researchers monitor for any…

This study tests several experimental drugs in people with NF2-related schwannomatosis, a rare genetic condition that causes non-cancerous tumors on nerves. The goal is to see if these drugs can shrink tumors or stop them from growing. About 109 participants will receive one of t…

This early-stage trial tests a precise type of proton therapy for children with ependymoma, a brain tumor. The treatment uses special beams to kill tumor cells while trying to protect healthy brain tissue. About 48 children whose tumor has not spread will be enrolled to see if th…

This early-stage study is testing whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG or recurrent medulloblastoma. The cells are designed to recogn…

This study watches 1650 people with different types of brain tumors to see if the new 2021 classification system helps doctors choose better treatments. Researchers will track how long patients live and how well their tumors respond to therapy. The goal is to create clearer treat…

This study tests a new approach for children and young adults whose medulloblastoma or ependymoma has come back. Doctors will analyze the tumor's genes and test drugs on it in real time to create a personalized treatment plan. The goal is to see if this can be done quickly enough…