DEEP BRAIN STIMULATION

This study compares a new adaptive form of deep brain stimulation (aDBS) to the standard continuous stimulation (cDBS) in 130 people with Parkinson's disease. The goal is to see if aDBS increases the amount of time patients feel good and can move well without bothersome side effe…

This study looks at the long-term safety of the drug buntanetap in 500 people with Parkinson's disease over 36 months. It includes two groups: those who have taken buntanetap before and those who have a deep brain stimulation device. Participants take one 30 mg pill daily, and re…

This study tests whether a new type of deep brain stimulation (DBS), called patterned stimulation, is safe and tolerable for people with Parkinson's disease to use at home. About 60 adults who already have stable DBS will try the new pattern for two weeks. The goal is to see if t…

This study tests a new therapy called CereGate for people with Parkinson's disease who experience freezing of gait—a sudden inability to move their feet while walking. The therapy is used alongside their usual medication and deep brain stimulation. Researchers will measure change…

This study tests whether a non-invasive technique called Low Intensity Focused Ultrasound Pulsation (LIFUP) can safely increase brain activity in a memory-related area and possibly improve memory. About 144 adults aged 50–90 with mild cognitive impairment or mild Alzheimer's will…

This study compares two types of anesthesia—general and regional—for people with Parkinson's disease who need their deep brain stimulator battery replaced. The goal is to see which method provides better pain control and higher patient satisfaction after surgery. About 50 adults …

This study tests whether following a Mediterranean diet for three months after deep brain stimulation surgery helps Parkinson's patients control weight gain and improve body composition. Twenty-four adults aged 45-64 who are scheduled for this surgery will be randomly assigned to…

This study is creating a shared database of information from up to 100 children who have had or will have deep brain stimulation (DBS) for conditions like dystonia, epilepsy, or Tourette syndrome. By combining data from multiple hospitals, researchers hope to learn which children…

This study aims to understand how different brain circuits affect movement and thinking in people with Parkinson's disease who already have a deep brain stimulation (DBS) device. Researchers will measure brain activity patterns during rest and movement, and link them to standard …

This study aims to find proteins and genetic material in the blood that can predict how well a person with Parkinson's disease will respond to deep brain stimulation (DBS) surgery. Researchers will collect blood and leftover brain tissue from 30 participants undergoing DBS, and t…

This study looks at how the brain's motor network works in children with dystonia, a movement disorder. Researchers will use noninvasive tests like EEG to measure brain activity at rest and during simple tasks. The goal is to learn how the brain changes over time and how deep bra…

This study aims to find the best settings for deep brain stimulation (DBS) in people with epilepsy that medications cannot control. Researchers will test different combinations of stimulation strength, speed, and pulse width in 20 adults who already have a DBS device. The goal is…

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Researchers will monitor brain activity and sleep quality in 64 adults who already have or will get a DBS device. The goal is to understand which brain pathways control sleep pr…

This study tests a new interface that synchronizes two brain stimulation methods—transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS)—in people with Parkinson's disease. Only 2 participants will be enrolled to see if the device can precisely time t…

This study looks at why deep brain stimulation (DBS) for Parkinson's disease can sometimes cause thinking or memory problems. Researchers will use brain scans to compare how the brain works with the stimulator turned on versus off. The goal is to help doctors choose the best stim…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse disorder. Researchers will measure brain responses and any changes in movemen…