CYSTIC FIBROSIS (CF)

This study looks at whether specific arm and leg exercises can improve muscle strength, breathing, and overall fitness in children aged 6 to 18 with cystic fibrosis. About 22 children will take part in a 10-month program at two hospitals in Lahore. The goal is to see if these exe…

This study tests a new medicine called ANG003 for people with cystic fibrosis who have trouble digesting food due to a lack of digestive enzymes. The goal is to see if ANG003 is safe and works as well as the current standard enzyme treatment, Creon. About 113 people aged 12 and o…

This study tests a wellness program for adults with cystic fibrosis who struggle with fatigue and poor sleep. About 80 participants will either join the program or continue their usual care. The program includes coaching sessions and uses a fitness tracker to monitor activity and…

This study tests a smartphone chatbot called NUDGE that helps teens and young adults (ages 13-25) with cystic fibrosis set activity goals, track progress, and stay motivated. Researchers want to see if the app is easy to use and keeps people engaged. The goal is to help participa…

This study tests whether a self-help smartphone toolkit based on Acceptance and Commitment Therapy (ACT) can reduce anxiety and depression in adults with cystic fibrosis. About 60 participants will use the toolkit on their phones and report changes in mood and psychological flexi…

This study looks at how a Mediterranean diet affects the gut health of children with cystic fibrosis. Twenty kids aged 3 and older will follow this diet for 6 months. Researchers will check changes in gut bacteria and inflammation to see if this diet can improve their health.

This study is testing a smartphone app called OnTrackCF to see if it is easy and helpful for adults with cystic fibrosis. About 60 people will use the app and answer surveys. The goal is to learn if the app works well, not to treat the disease directly.

This study aims to understand why people with cystic fibrosis (CF) often develop kidney disease. Researchers will collect blood and urine samples from 260 participants with CF, both during routine clinic visits and during hospital stays for lung flare-ups. They will look for earl…

This study will enroll 200 adolescents and adults with cystic fibrosis-related diabetes (CFRD) to find out how common complications like eye, kidney, and nerve problems are. Researchers will also check blood pressure and cholesterol. The goal is to better understand these risks a…

This study tests whether wearable sensors and artificial intelligence can detect changes in the body during a chest infection in adults with cystic fibrosis or bronchiectasis. Researchers will measure things like heart rate and breathing rate at the start and end of antibiotic tr…

This study tests whether an online education program can help children aged 6-11 with cystic fibrosis and their parents better understand health information. About 104 children and their parents will be split into two groups: one receives the online lessons, the other does not. R…

This study looks at adults with cystic fibrosis who are taking the drug combination ETI. Researchers want to find out how many of them have trouble breathing during a 6-minute walk test. The goal is to better understand how well the lungs work during exercise while on this treatm…

This study looks at how Alpha-1 Antitrypsin Deficiency and Cystic Fibrosis affect white blood cells in the lungs called macrophages. Researchers will collect blood from 220 adults to test how well these cells work. The goal is to better understand these diseases, not to provide a…

This study aims to uncover differences in breathing difficulty, muscle strength, bladder control, and quality of life between children with cystic fibrosis (ages 6-18) and healthy children of the same age. Researchers will measure hand grip strength, lung function, and use questi…

This study looks at how the cystic fibrosis drug Kaftrio (elexacaftor-tezacaftor-ivacaftor) behaves in children aged 2 to 17. Researchers will measure drug levels in the blood and check for side effects like liver problems or mood changes. The goal is to make the drug safer and m…

This study looks at whether adults with cystic fibrosis (CF) who are taking a highly effective new medication can safely stop their usual nasal treatments, like saltwater rinses and steroid sprays. Researchers will check sinus health, lung function, and quality of life over time.…

This study aims to make sure lab tests, equipment, and procedures used in research on obesity, diabetes, heart disease, and bone disorders are accurate and give consistent results. It will involve up to 100 healthy volunteers and people with these conditions, aged 18 to 100. The …

This study looks at how linaclotide, a medicine for constipation, works inside the gut. Researchers will use MRI scans to see where it adds water in the small intestine and colon. 26 healthy adults aged 18-60 will take the medicine or a placebo in random order. The goal is to lea…

This early-stage study tests whether experimental drugs SION-451, SION-2222, and SION-109 are safe in healthy adults aged 18 to 55. Researchers will give single or multiple doses and watch for side effects. The goal is to find safe doses before testing in people with cystic fibro…

This study follows 200 people with cystic fibrosis (CF) to learn more about severe lung flare-ups (exacerbations) and how well standard antibiotic treatments work. Researchers will track symptoms, lung function, and collect samples to understand why some people recover faster tha…

This study aims to see if a mobile app can reliably measure muscle fatigue in people with cystic fibrosis (CF). Researchers will compare muscle fatigue between 68 participants with CF and healthy controls using a smartphone app that analyzes a sit-to-stand test. The goal is to pr…

This study follows 300 people with cystic fibrosis for a year to learn what triggers sudden worsening of symptoms (called exacerbations), like increased coughing and breathlessness. Participants provide regular health data and samples; some also undergo extra testing at clinic vi…

This study investigates whether germs called non-tuberculous mycobacteria (NTM) that cause lung infections in people with cystic fibrosis (CF) live in home water systems. Researchers will collect water, dust, and soil samples from 120 CF patients' homes—half with NTM infection an…

This study follows 60 women with cystic fibrosis (CF) who are planning a pregnancy, are pregnant, or have recently given birth. Researchers will track their lung function, nutrition, and mental health, as well as the health of their babies. The goal is to learn what extra care or…

This study tests new ways to measure lung function in 60 people with cystic fibrosis. Participants will breathe in a harmless gas (xenon) for a special MRI and do a simple breathing test. The goal is to get a clearer picture of how the lungs change over time, which could help imp…

This study looks at how the cystic fibrosis drug combination ETI (elexacaftor-tezacaftor-ivacaftor) affects metabolism, gene activity, and gut bacteria in 150 people with CF. Researchers want to understand why some patients develop side effects like high cholesterol or obesity. T…