Cystic fibrosis (CF)

This study tests whether adding a new drug called SION-719 to the standard CF medication Trikafta is safe and helps people with cystic fibrosis who have two copies of the F508del mutation. Sixteen participants will receive either SION-719 or a placebo alongside their usual Trikaf…

This early-stage trial tests the safety of three experimental drugs (SION-451, SION-2222, and SION-109) given together to healthy adults aged 18–55. The study aims to see if the combinations are safe and how the body processes them. It is a first step toward possibly developing a…

This study looked at whether children with cystic fibrosis (CF) who are taking CFTR modulator drugs and have regained normal pancreatic function can safely stop taking pancreatic enzyme replacement therapy (PERT). Seventeen children were followed for six months after stopping enz…

People with cystic fibrosis often develop prediabetes and then diabetes, but doctors lack a good way to predict who will progress. This pilot study at Indiana University tests whether a continuous glucose monitor worn for up to 10 days, combined with a mathematical model called t…

This study tested an online group therapy program designed for adults with cystic fibrosis (CF) to help reduce depression, anxiety, and stress. Twenty-one participants completed questionnaires before and after the 8-week program, and some shared their experiences in interviews. T…

This study tested a new 3-session mind-body pain management program called PACE CF for adults with cystic fibrosis (CF). The program was delivered via telehealth and aimed to help people cope with pain without medication. Researchers wanted to see if the program was acceptable an…

This study tested a wearable vest called ELECTROVEST that vibrates and gently stimulates muscles to help clear mucus from the lungs. It included 21 adults with COPD, cystic fibrosis, bronchiectasis, or asthma. The vest was compared to a standard chest-vibration device to see if i…

This study explores whether machine learning can predict lung function in children with cystic fibrosis using previously collected data on muscle oxygenation, postural balance, and other clinical markers. Researchers will analyze archived spirometry, exercise, and quality-of-life…

This study tested whether a single 30-40 minute online education program could improve health literacy in 104 school-age children with cystic fibrosis and their parents. Half the families received the program, while the other half did not. Researchers measured health literacy lev…

This study tested whether a mobile app can reliably measure muscle fatigue in people with cystic fibrosis (CF). Researchers compared 100 participants with CF to healthy controls using a chair-rising test captured by the app. The goal was to see if the app could detect differences…

This completed study looked at 88 children with cystic fibrosis (CF) or primary ciliary dyskinesia (PCD) to compare how well they can exercise, how their muscles use oxygen, and how strong their breathing muscles are. Researchers used walking tests and muscle oxygen monitors to m…

This completed study looked at how well children with cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) can use their arms for exercise, how their muscles use oxygen, and their balance. Researchers compared 88 children aged 6-18 with CF, PCD, and healthy peers. The goal w…