CROHN'S DISEASE

This study aimed to see if stem cells from a donor could safely help heal fistulas in people with Crohn's disease who have an ileal pouch. It planned to enroll adults aged 18-75 with a pouch in place for at least 6 months. However, the study was withdrawn before any participants …

This study tests a drug called guselkumab in about 1,400 people with moderate to severe Crohn's disease. The goal is to see if it can reduce symptoms like abdominal pain and diarrhea, and also heal the gut lining when viewed with a camera. Participants receive either the study dr…

This study tests an injected drug called risankizumab for adults with moderate-to-severe Crohn's disease, a condition causing painful gut inflammation. About 289 participants will receive either the drug or a placebo for up to 24 weeks, then all may receive the drug for another y…

This early-stage trial aimed to test the safety of injecting donor stem cells around fistulas in people with Crohn's disease. The goal was to see if the treatment could help close these abnormal tunnels without causing serious side effects. However, the study was withdrawn before…

This study looks at how safe and effective the drug Entyvio (vedolizumab) is over the long term for people with moderate to severe Crohn's disease. It involves 335 patients who did not get better with other treatments. Researchers will track side effects and how well the drug con…

This study looks at whether two special diets—a liquid formula diet or the specific carbohydrate diet—can help people with active Crohn's disease or ulcerative colitis feel better. About 40 adults will choose one diet and follow it for 6 weeks, then return to normal eating. Resea…

This study tests whether combining two drugs (guselkumab and golimumab) works better than either drug alone for people with moderate to severe Crohn's disease. About 703 adults will receive the combo or a placebo to see if it improves symptoms and gut healing after 48 weeks. The …

This study tests a drug called guselkumab in 120 adults with Crohn's disease. The goal is to see if it can heal all layers of the digestive tract, not just the surface. Doctors use MRI scans to measure healing at 48 weeks. This is an open-label study, meaning everyone knows they …

This study tests whether a daily pill called upadacitinib can help adults with Crohn's disease stay in remission and prevent symptoms from coming back. About 747 people who already improved on the drug in an earlier study will either continue taking it or switch to a placebo. The…

This study looks at how safe and effective the drug mirikizumab is over the long term for people with Crohn's disease. About 1,000 adults who completed a previous mirikizumab study are taking the drug for another year. The goal is to see if it can keep the gut healthy and reduce …

This study aimed to test if stem cells from donated bone marrow are safe and workable for people with severe pouchitis, a complication after colon surgery for inflammatory bowel disease. It was designed for adults aged 18-75 who had not responded to standard treatments. The study…

This study tests whether a fecal microbiota transplant (FMT) can safely and effectively treat recurrent C. difficile infections in children, including those with inflammatory bowel disease (IBD). Researchers will give healthy donor stool to 250 participants aged 3 to 21 and monit…

This early-phase study tested an oral herbal formula (E-B-FAHF-2) in 7 adults with mild-to-moderate Crohn's disease. The goal was to see if it is safe and tolerable, and to gather early signs of whether it might help control the disease. The formula is a concentrated version of a…

This study is observing over 1,000 adults in Brazil with ulcerative colitis or Crohn's disease who are taking or have taken vedolizumab. Researchers are looking at how long people stay on the treatment and what other therapies they have used. No new treatments are being tested—th…

This study looks at how well a tool called CDPATH™ works in real doctor visits. The tool predicts the chance of serious Crohn's disease problems in the next 3 years. About 200 adults with Crohn's will use the tool to help their doctors choose the best treatment. The goal is to se…

This study follows 15,000 adults and children (age 2+) with Crohn's disease, ulcerative colitis, or indeterminate colitis for up to 5 years. Researchers will collect data on how patients respond to treatments, side effects, and disease changes in everyday medical practice. The go…

This study is a long-term registry that follows nearly 5,000 children with inflammatory bowel disease (Crohn's, ulcerative colitis, or indeterminate colitis) to monitor their safety and health over time. Researchers collect information on side effects from treatments like inflixi…