CROHN'S DISEASE

This study looked at whether the drug vedolizumab can help adults with moderate to severe Crohn's disease achieve complete remission—meaning fewer symptoms and less bowel inflammation—after 12 months of treatment. Researchers followed 72 participants in Canada, Italy, and Israel …

This study tested two nutrition-based maintenance therapies in 100 children (ages 6-18) with Crohn's disease who were already in remission after an initial course of exclusive enteral nutrition. One group received all their daily calories from a liquid formula (cyclic exclusive e…

This study checked if switching from the original drug Remicade to its biosimilar Inflectra works just as well for patients with rheumatoid arthritis, spondyloarthritis, Crohn's disease, or uveitis. 262 adults who had already received at least three doses of Remicade were switche…

This study tested a web-based telemonitoring system called TECCU for people with moderate-to-severe inflammatory bowel disease (Crohn's disease or ulcerative colitis). 290 adults who were starting new treatments were randomly assigned to use the TECCU system or receive usual care…

This study looked at the long-term safety of the drug vedolizumab in children aged 2 to 17 with ulcerative colitis or Crohn's disease. 59 children who had already responded to the drug in an earlier study continued treatment. The main goal was to track any side effects over time.

This study looked at how safe and effective upadacitinib (RINVOQ) is for Korean adults with moderate to severe ulcerative colitis or Crohn's disease. About 600 patients took the drug as prescribed by their doctor and were followed for up to 52 weeks. The main goal was to track an…

This study looked at the safety of giving extra doses of a stem cell drug called Remestemcel-L to 73 people with moderate-to-severe Crohn's disease that didn't respond to standard treatments. All participants had already received this treatment in an earlier study. The goal was t…

This study tested whether infusions of adult stem cells (PROCHYMAL) could help people with moderate-to-severe Crohn's disease who had not responded to standard treatments. Participants received four intravenous doses over two weeks. The goal was to see if the stem cells could saf…

This study followed 156 people in China with moderate-to-severe Crohn's disease who were prescribed Humira (adalimumab) by their doctors. Researchers tracked serious side effects and how well the drug controlled disease activity over one year. The goal was to see how Humira works…

This study looked at whether a higher dose (10 mg/kg) of the drug TA-650 (also known as infliximab) given every 8 weeks could help people with Crohn's disease whose symptoms were not well controlled with the standard dose. A total of 39 adults took part. The main goal was to see …

This study tested whether infusions of special stem cells (PROCHYMAL) could help people with moderate-to-severe Crohn's disease who had already improved with an earlier stem cell treatment. The goal was to see how long the benefit lasts and if a repeat infusion can bring back imp…

This study tested whether curcumin (the active ingredient in turmeric) can prevent Crohn's disease from coming back after surgery. Researchers compared curcumin to standard thiopurine drugs in 61 adults who had just had surgery for Crohn's. The goal was to see if curcumin could b…

This study looked at the gut bacteria of 214 people with Crohn's disease, comparing those diagnosed as children (under 17) with those diagnosed after age 40. The goal was to see if the bacteria and genetic factors differ by age, which could mean Crohn's is actually different dise…

This study observed 165 people with inflammatory bowel disease (IBD) in Poland who were taking vedolizumab either as an IV infusion or a subcutaneous injection. Researchers tracked how long patients stayed on their treatment, why some switched or stopped, and what other treatment…

This study looked at whether measuring certain antibodies (ASCA) from gut biopsies can help understand Crohn's disease better than standard blood tests. Researchers compared 80 people with Crohn's, 40 with ulcerative colitis, and 40 without inflammatory bowel disease. No treatmen…

This study looked at 669 people with Crohn's disease to see if finding anal fistulas early with routine MRI scans, even before symptoms appear, leads to better long-term health. Researchers compared those with hidden fistulas to those with obvious symptoms to understand how the d…

This study looked at nearly 24,000 older adults (65+) with ulcerative colitis or Crohn's disease to compare infection risks from three types of advanced treatments: ENTYVIO, TNF-alpha inhibitors, and ustekinumab. Researchers used existing Medicare claims data from 2016 to 2025 to…

This study looked at whether regularly measuring the amount of anti-TNF medication and antibodies in the blood helps doctors make better treatment decisions for people with Crohn's disease or ulcerative colitis. 260 patients were split into two groups: one where doctors had acces…