COLORECTAL CARCINOMA

This study tests a drug called tegavivint in children, teens, and young adults (ages 1 to 30) whose solid tumors have returned or not responded to standard therapy. The drug works by blocking a key signal that tells cancer cells to grow. The trial aims to find the safest dose, un…

This study tests a drug called zanidatamab in adults with certain advanced cancers (lung, colorectal, head and neck, sarcoma, or endometrial) that have a specific change in the HER2 gene. The goal is to see if the drug can shrink tumors. Participants receive the drug by IV every …

This early-stage study tests a new treatment using a patient's own immune cells, modified in a lab to recognize and attack cancer cells with a specific KRAS mutation (G12D). It is for adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have not respond…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 uses the patient's own T cells, which are modified in…

This early-phase trial tests a new medicine, BI 765049, in adults with advanced colorectal, stomach, or pancreatic cancer that cannot be removed by surgery or has spread. The main goal is to find the highest safe dose and best way to give the drug. BI 765049 is designed to help t…

This early-phase study tests a new drug called MGC028 in adults with advanced solid tumors (lung, bile duct, pancreas, or colon cancer) that have not responded to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors or stop them from g…

This early-stage study tests an oral drug called S241656 in adults with advanced cancers that have certain gene changes (KRAS, BRAF, or related mutations). The drug is given alone or with other cancer treatments. The goal is to find safe doses and see if the drug shrinks tumors. …

This study tests a new treatment approach for people with rectal cancer that has spread to a limited number of other organs (oligometastases). The treatment combines short-course radiation, chemotherapy, and an immunotherapy drug called serplulimab. The goal is to see if this com…

This study tests a drug called zanidatamab given before surgery to people with HER2-positive colorectal cancer. The goal is to see if the drug can shrink or eliminate tumors, making surgery more effective. About 38 adults with early-stage cancer will take part, and researchers wi…

This trial tests an experimental drug called CP-383 in people with advanced solid tumors that have not responded to standard treatments. The goal is to see if CP-383 can slow or stop cancer growth and to find the safest dose. About 150 participants will take the drug daily and ha…

This study tests a drug called TPST-1495 in 38 people with familial adenomatous polyposis (FAP), an inherited condition that causes many polyps in the colon and small bowel and raises colon cancer risk. The drug works by blocking certain signals that help polyps grow. The main go…

This study tests a personalized vaccine made from a patient's own immune cells, combined with an immunotherapy drug (nivolumab), after surgery to remove liver cancer or colorectal cancer that spread to the liver. The goal is to see if this treatment can prevent the cancer from re…

This early-phase trial tests a new drug called JANX008 in adults with advanced solid tumors (like lung, kidney, breast, or colorectal cancer) that have stopped responding to standard treatments. The main goals are to check safety, find the right dose, and see if the drug can shri…

This study looks at whether a stool DNA test can accurately detect colorectal cancer or pre-cancerous growths in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will collect blood and stool samples from 750 adults with Lynch syndrome or early-…

This study is creating a blood test that uses artificial intelligence to find early signs of colorectal cancer and advanced polyps. Researchers will combine markers in the blood with personal risk factors to build a smart algorithm. The goal is to make screening easier and catch …

This study aims to reduce colorectal cancer disparities in Black and underserved communities in Phoenix by providing free, home-based screening tests and education. Participants aged 45 and older who meet eligibility criteria will receive a fecal immunochemical test (FIT) kit and…

This early-stage trial tests the safety of a drug called ONC201 (dordaviprone) in 36 adults at high risk for colorectal cancer due to familial adenomatous polyposis (FAP) or a history of many polyps. The drug aims to kill precancerous cells without harming healthy ones. If succes…

This study tests a community program to increase cancer screenings for breast, cervical, and colorectal cancer in low-income women in Central Ohio. The program includes patient education, media campaigns, and training health workers to help women get screened. About 2,067 women w…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study tests a web-based program for colorectal cancer patients on chemotherapy and their caregivers. The program targets common symptoms like fatigue, depression, sleep problems, pain, and brain fog. Researchers want to see if it's easy to use and helps improve quality of li…

This study looks at whether moderate-to-vigorous exercise can change the gut bacteria in people who have had stage II or III colorectal cancer. Researchers want to see if these changes might help lower the risk of cancer coming back. The trial involves 30 survivors and focuses on…

This study tests a program to help patients with high-risk colon polyps get a follow-up colonoscopy within the recommended 3 years. The program works with clinics, doctors, and patients to make scheduling easier and remind people of the importance of this screening. About 1,680 a…

This study looks at whether a training program for community health workers can help Hispanic/Latino adults learn more about preventing colorectal cancer and genetic testing. About 140 people from Los Angeles County will take part. Researchers will measure changes in knowledge an…

This study follows 2000 adults with newly diagnosed cancers (breast, colorectal, lung, melanoma, or lymphoma) who are receiving chemotherapy or immunotherapy. Researchers will track whether using cannabis or cannabinoids helps reduce symptoms like pain, nausea, or fatigue, and al…

This study looks at blood and tumor tissue from 500 Hispanic patients with colorectal cancer to understand why the same cancer can respond differently to treatment. By combining genetic information with clinical data, researchers hope to match treatments to each patient's unique …

This study is testing new blood tests that look for signs of many different cancers at the same time. The goal is to see if these tests can find cancer early, when treatment works best. About 24,000 adults aged 45 to 75 who do not have cancer will take part. They will be placed i…

This study works with community leaders and genetic experts to create an online education program for African American cancer survivors. The goal is to help more people understand and choose genetic counseling and testing. About 85 participants from Detroit will try the program a…

This study tracks 120 young adults (women under 40, men under 50) with early-onset colorectal cancer to see how chemotherapy and radiation affect their hormone levels, sexual health, and ability to have children. Researchers will measure changes in key hormones over time. The goa…

This study aims to see if a special planning tool helps more people get screened for colorectal cancer. About 2,200 patients from 20 primary care clinics will use the tool to decide when and how to get screened. The goal is to find the best way to make screening a routine part of…

This study tests whether an online platform helps cancer patients track medication safety events and concerns while taking oral anticancer drugs at home. About 80 adults with lung, colorectal, breast, or prostate cancer will use the system to log symptoms and issues. Researchers …

This study tests a clinic-wide program called Primary Care-GI Connect to improve follow-up colonoscopy rates in people who had an abnormal stool-based colorectal cancer screening test (FIT). The program helps coordinate care, standardize referrals, and engage doctors. About 1,500…

This study looks at how what you eat and the bacteria in your gut might influence the development of colorectal cancer. Researchers will collect tissue, stool, and blood samples from 30 people undergoing screening colonoscopies. The goal is to understand connections between diet,…

This study creates a database of information from people diagnosed with colorectal cancer before age 50. Researchers will use this data to compare young-onset and later-onset colorectal cancer, and to guide future research. About 1,366 participants will provide medical informatio…