COLORECTAL CARCINOMA

This trial tests a vaccine called Nous-209 in 45 people with Lynch syndrome, an inherited condition that raises the risk of colorectal and other cancers. The vaccine is designed to train the immune system to recognize and attack abnormal cells that could become cancer. The study …

This study looks at whether a regular endurance exercise program (like walking or jogging) after finishing chemotherapy can help prevent colorectal cancer from returning. About 92 adults who have completed their chemo will be randomly assigned to either an exercise group or a sta…

This study tests the drug pembrolizumab in about 1,600 people with advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can shrink tumors and to identify biomarkers that predict response. Participants receive pembrolizumab and are m…

This study tests whether giving chemotherapy before and after surgery (plus heated chemotherapy during surgery) helps people with colorectal cancer that has spread to the abdomen lining live longer compared to surgery alone. About 358 adults with resectable cancer will be randoml…

This study compares two treatments—microwave ablation and stereotactic body radiation therapy—for colorectal cancer that has spread to the liver in 100 patients. The goal is to see which method better controls tumor growth with fewer side effects. Participants have 1 to 3 liver t…

This study tests whether adding the drug tucatinib to standard treatments (like trastuzumab and chemotherapy) is safe for people with HER2-positive cancers of the digestive system. About 40 adults with advanced cancer of the colon, stomach, esophagus, or gallbladder will receive …

This study is for people with advanced solid tumors (like lung or colorectal cancer) that have a specific genetic change called KRAS G12C. It tests a new drug, JDQ443, combined with other treatments to see if they are safe and can shrink tumors. About 74 adults will take part. Th…

This study tests whether offering a patient navigator, an educational video, and free rideshare rides helps more people complete a follow-up colonoscopy after an abnormal at-home stool test for colorectal cancer. About 682 adults aged 45-75 who are due for this follow-up will tak…

This early-stage study tests a new radioactive tracer called 18F-αvβ6-BP to see if it can safely and effectively highlight cancers in the breast, colon, lung, pancreas, and related metastases. About 27 adults with these cancers will receive the tracer and undergo PET scans. The g…

This study tests whether a low-radiation CT scan, enhanced with artificial intelligence software, can find liver tumors as accurately as a standard CT scan. About 146 adults with colorectal cancer that has spread to the liver will participate. The goal is to see if the new method…

This study tests whether atorvastatin, a widely used cholesterol-lowering drug, can reduce the risk of colon cancer in people with long-standing ulcerative colitis who carry a specific genetic mutation (P53). About 42 participants will receive either atorvastatin or a placebo for…

This study tests whether a combination of two experimental drugs (Tri-Ad5 vaccine and N-803) can prevent colon cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. The vaccine trains the immune system to recognize and destroy precancerous cells, whil…

This study looks at whether taking aspirin in a specific pattern can help prevent colorectal cancer in people who already have growths called adenomas. Aspirin may block certain enzymes that help cancer cells grow. The trial involves 81 adults with colorectal adenomas and measure…

This study tests a vaccine that helps the immune system recognize and attack cells in advanced colon polyps, which can turn into cancer. About 110 people who recently had such polyps removed will receive either the vaccine or a placebo. The goal is to see if the vaccine boosts im…

This study looks at genetic factors that may increase the risk of developing colorectal cancer at a young age (18-50). Researchers will compare medical records, lifestyle information, and genetic data from 818 patients and their family members. The goal is to find genetic markers…

This study follows about 400 adults who previously received A2Bio gene therapy for various solid tumors, including lung, colon, and pancreatic cancers. The main goal is to track long-term safety and see how well the treatment effects last over time. Participants do not receive ne…

This study tests a program to increase colorectal cancer screening among low-income and ethnic minority groups, who are often hit harder by this cancer. Researchers will help clinics and doctors encourage eligible patients (ages 50-75) to complete a simple at-home stool test (FIT…

This study tests a web-based education tool called HOPE-Genomics that teaches cancer patients about their genetic test results. About 465 adults with lung, breast, colorectal, pancreatic, ovarian, or prostate cancer are taking part. The goal is to see if the tool helps patients r…

This study tests whether analyzing the genes in a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced or hard-to-treat cancers (solid tumors, lymphoma, or myeloma) had their tumors genetically screened. Those with specific genetic c…

This study looks at what helps or hinders people from getting screened for colorectal cancer, focusing on African American, Latinx, and Chinese communities. Researchers will interview and hold focus groups with about 90 participants to understand their knowledge, beliefs, and cul…

This study was designed to look at how community cancer clinics test for biomarkers in common cancers like lung, breast, and colorectal cancer. The goal was to find out if testing is fast and accurate, and to spot any differences in how tests are done. However, the study was with…

This study tests a training program for Hispanic/Latino community members to learn about colorectal cancer genetics. About 20 participants will attend weekly sessions for 6 weeks. The goal is to see if the program increases their knowledge and confidence to share this information…