Vaccine aims to stop colon cancer before it starts in lynch syndrome patients
NCT ID NCT05419011
First seen Jan 04, 2026 · Last updated Jun 18, 2026 · Updated 29 times
Summary
This study tests a special vaccine (Tri-Ad5) plus an immune booster (N-803) to see if it can prevent colon and other cancers in 186 people with Lynch syndrome, a genetic condition that raises cancer risk. The vaccine trains the immune system to recognize and destroy precancerous cells. The main goal is to lower the number of polyps and cancers that develop over time.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Mayo Clinic Hospital in Arizona
Phoenix, Arizona, 85054, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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UCHealth University of Colorado Hospital
Aurora, Colorado, 80045, United States
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UCSF Medical Center-Parnassus
San Francisco, California, 94143, United States
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UT MD Anderson Cancer Center
Houston, Texas, 77030, United States
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University of Arizona Cancer Center - Prevention Research Clinic
Tucson, Arizona, 85719, United States
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University of Kansas Cancer Center
Kansas City, Kansas, 66160, United States
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University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109, United States
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University of Puerto Rico
San Juan, 00936, Puerto Rico
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.