LYNCH SYNDROME

This pilot study tests a new device called the Retro-TCE capsule, which is a small camera attached to a string that is inserted into the lower gut to take pictures without needing sedation. The study will enroll 30 people, including healthy volunteers and those with Lynch syndrom…

This study is for people with Lynch syndrome, a condition that raises the risk of colorectal cancer. Researchers want to see if a stool DNA test can find cancer or pre-cancer growths as accurately as a colonoscopy. About 950 adults will provide blood and stool samples to help eva…

This study tests whether people with Lynch syndrome can use a self-collected vaginal swab at home to detect early signs of uterine cancer. Researchers will check if participants find the process easy and acceptable, and whether DNA from the swab can predict cancer risk. The goal …

This study is testing a blood test (called a liquid biopsy) to see if it can find colorectal cancer, pre-cancerous growths (adenomas), and cancers linked to Lynch syndrome at an early stage. Researchers will enroll 1,200 people who have already had a colonoscopy. The goal is to s…

This study looks at whether a menstrual cup can collect enough uterine tissue to screen for endometrial cancer, especially in women with Lynch syndrome who are at higher risk. About 25 participants will use a menstrual cup at home and also have a standard biopsy, then compare the…

This study is testing whether a urine test that looks for tumor DNA can find bladder and urinary tract cancers early in people with Lynch syndrome, a genetic condition that raises cancer risk. About 200 participants aged 50–75 will provide urine samples and be followed for one ye…

This study tests whether naproxen or aspirin can increase immune cells in the colon to prevent cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. About 40 participants will take one of these drugs or a placebo for a short time. Researchers will mea…

This study tests whether a smartphone app, combined with nutrition education, can help people at high risk for cancer eat healthier and reduce their cancer risk. About 170 participants will either get the app or standard advice, and researchers will measure changes in diet qualit…

This early-stage study tests a new vaccine made from a person's own immune cells to see if it can prevent cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. The vaccine is designed to train the immune system to recognize and attack cells that might…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study aims to discover new genes that may cause certain cancers to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had cancer, especially childhood cancers. The goal is to build a regist…

This study is testing whether a swallowed video capsule (a pill-sized camera) can help find small bowel cancer early in people with Lynch syndrome, a genetic condition that raises cancer risk. About 100 participants will swallow a capsule every two years to take pictures of their…

This study compares genetic counselling done by video (telegenetics) with traditional in-person sessions for people at risk of hereditary breast, ovarian, or colorectal cancer. Researchers will measure how well patients understand their options, their emotional responses, and the…

This study aims to create a large collection of blood samples from 2,500 people with or at high risk for cancer. Researchers will use these samples to study liquid biopsies, which are blood tests that may help detect cancer, track treatment response, and spot recurrence. Particip…

This study offers free genetic testing to the general public to find people with inherited cancer syndromes like hereditary breast and ovarian cancer or Lynch syndrome. Researchers want to see if broad testing is better than only testing those with a family history. Up to 27,500 …

This study looks at how the immune system's surveillance might influence the development of colorectal cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will follow 300 participants to see if immune markers can better predict who will …

This study compares an artificial intelligence system (CAD-EYE) to the standard dye-spray method for finding precancerous polyps during colonoscopy in people with Lynch syndrome, a genetic condition that raises colorectal cancer risk. About 272 participants will be randomly assig…

This study reviews past medical records of 400 people with Lynch syndrome who had a small bowel capsule endoscopy (a pill-sized camera) to screen for pre-cancerous growths or cancer in the small intestine. The goal is to see how well this camera test finds these lesions compared …

This study looks at families in Switzerland who carry genes that raise the risk of breast, ovarian, colorectal, or endometrial cancers. Researchers will survey both the person with the gene mutation and their close relatives to understand how many get tested and what barriers the…

This study aims to find better ways to detect pancreas cancer early in people who are at high risk due to family history or certain gene mutations. Researchers will collect and analyze pancreatic juice and cyst fluid from 9,000 participants to look for markers that signal early c…