LYNCH SYNDROME

This study tests whether a swallowable capsule with tiny cameras can effectively screen for colon cancer in people with Lynch syndrome, a genetic condition that greatly increases colon cancer risk. Participants will undergo both the capsule exam and a standard colonoscopy to comp…

This early-phase trial tests a personalized vaccine made from a person's own immune cells (dendritic cells) loaded with cancer-specific markers. The goal is to train the immune system to recognize and destroy precancerous cells in people with Lynch syndrome, who have a high risk …

This phase III trial tests whether a vaccine made from a person's own immune cells can prevent cancer in 372 adults with Lynch syndrome, a genetic condition that raises cancer risk. Participants receive either the vaccine or a placebo and are monitored for tumor development. The …

This study tests an online tool called 'Let's Talk' designed to help people with Lynch syndrome encourage their relatives to get screened for the condition. Lynch syndrome is a genetic disorder that raises cancer risk, and only about half of close relatives currently get tested. …

This study aims to find out how often Muir-Torre syndrome (MTS) occurs in people who already have Lynch syndrome, a genetic condition that raises cancer risk. Researchers will examine skin lesions and tumors from 150 participants to see if they are linked to MTS. The goal is to b…

This study looks at whether easy-to-collect samples like blood, urine, stool, and vaginal swabs can predict cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. Currently, monitoring requires invasive procedures like colonoscopies. The goal is to see…

This study tests a web-based program called Kindred that helps African American families understand their genetic cancer risk and talk about testing. About 150 people will use the tool to see if it improves knowledge and testing rates. The goal is to make genetic information more…

This study will check if a newer, cheaper DNA sequencing machine (MGI) gives the same results as the current standard (Illumina) when testing for genetic changes linked to breast, ovarian, and other cancers. Researchers will use leftover DNA samples from 248 patients who already …

This study aims to find out how common gum disease (periodontitis) is in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will compare gum health in 25 adults with Lynch syndrome to general population data. No treatment is given; the study simp…