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Could a pill camera replace the colonoscopy for lynch syndrome patients?

NCT ID NCT07445828

Diagnosis Sponsor: Region Skane Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a swallowable capsule camera (colon capsule endoscopy) can effectively screen for colorectal cancer in people with Lynch syndrome, a genetic condition that greatly increases cancer risk. Researchers will compare the capsule's ability to find polyps and other abnormalities against the standard colonoscopy in 78 participants. The goal is to see if this less invasive method is safe, accurate, and more comfortable for patients who need frequent surveillance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
colon capsule endoscopy (a swallowable camera device)
What this could lead to
If successful, this could offer a less invasive, more comfortable screening option for people with Lynch syndrome, potentially improving adherence to regular surveillance.
What could go wrong
This is a small, early-stage study (78 participants) comparing a new method to the standard. The capsule may miss some polyps, and bowel preparation is critical. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 78 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adults aged 18-60 years with genetically confirmed Lynch syndrome who are referred for guideline-based surveillance colonoscopy at Skåne University Hospital, Malmö. Eligible participants are identified by referring physicians at the endoscopy unit or gastroenterology outpatient clinic. Consecutive patients who meet the inclusion criteria and have no contraindications to colon capsule endoscopy or study participation are invited to enroll. Participants undergo both non-invasive colon capsule endoscopy and conventional colonoscopy according to the study protocol. Written informed consent is obtained by a study physician prior to any study-related procedures and documented in the medical record. Participation is voluntary, and participants may withdraw at any time without impact on future medical care. A total of 80 consecutive patients will be enrolled. The study evaluates the diagnostic performance and safety of colon capsule endoscopy as a first-line

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Genetically confirmed Lynch syndrome with a planned surveillance colonoscopy according to guideline-based recommendations * Age 18-60 years * Written informed consent obtained Exclusion Criteria: * Need for an translator * Known history of gastroparesis or intestinal pseudo-obstruction * Known or suspected stricture or stenosis of the gastrointestinal tract * Previous small bowel or colonic resection * Dysphagia or swallowing difficulties * Severe debilitating disease * Allergy or contraindication to any medications or products used in the study * Pregnancy or breastfeeding

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Conditions

The condition(s) this trial relates to.

Colorectal Neoplasms, Hereditary Nonpolyposis Lynch syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lynch syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Skane University Hospital Malmö

    Malmö, Skåne County, 20502, Sweden

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