COLORECTAL ADENOCARCINOMA

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have returned or spread. The therapy, called Tmod CAR T cells, is designed to find and kill cancer cells while trying to avoid harming the patient's healthy cells. Researchers…

This study is testing a new method to personalize a treatment called heated abdominal chemotherapy (HIPEC) for people with advanced appendix or colorectal cancer that has spread within the abdomen. Doctors will first test a small sample of a patient's tumor in a lab to see which …

This study is comparing a new drug combination (AK112 plus chemotherapy) against the current standard treatment (bevacizumab plus chemotherapy) for people newly diagnosed with metastatic colorectal cancer. It aims to see if the new combination is more effective at controlling the…

This study is testing a new type of cancer drug that delivers radiation directly to tumors by targeting a protein called Nectin-4. It aims to find a safe and effective dose for patients with advanced solid cancers who have already tried other treatments. The trial will first dete…

This is a first-in-human study testing a new drug called CLSP-1025 for adults with advanced solid tumors that have a specific genetic change called the p53 R175H mutation. The main goals are to find a safe dose and see if the drug can help control the cancer. The drug works by en…

This study is testing the safety and effectiveness of combining two drugs, VS-6766 and cetuximab, for people with advanced colorectal cancer that has a specific genetic change called a KRAS mutation. The study is for people whose cancer has continued to grow despite trying standa…

This study is testing a new first-line treatment for people with advanced, HER2-positive colorectal cancer that cannot be removed by surgery. It combines three drugs—trastuzumab-deruxtecan, capecitabine, and bevacizumab—to see how well they shrink tumors and control the disease. …

This study is testing a new type of cell therapy called A2B395 for adults with advanced solid tumors that have spread or returned. The therapy uses modified immune cells designed to specifically kill cancer cells while protecting the patient's healthy cells. The main goals are to…

This study is testing a new microwave-based device used during colonoscopy to see if it can safely help doctors find more colorectal polyps. It will be used in 50 patients who already have a known polyp and are scheduled for its removal. The main goals are to see if the device de…

This study aims to create and validate a new, non-invasive blood test to detect early-onset colorectal cancer in adults under 50. Researchers will analyze tiny genetic signals in the blood using advanced computer models to build a highly accurate test. The goal is to provide a si…

This study is testing a new blood test to see if it can better predict which colon cancer patients are at high risk of their cancer returning after surgery. The test looks for tiny pieces of cancer DNA left in the blood. Researchers will enroll 1,600 patients to see if this test …

This study is testing whether a simple blood test can find tiny amounts of leftover cancer cells after treatment. Researchers want to see if this test can predict if colorectal cancer will come back or spread earlier than current scans and check-ups. The study involves collecting…