CHRONIC MYELOMONOCYTIC LEUKEMIA

This study is testing if using a lower dose of a key drug (cyclophosphamide) after a stem cell transplant can reduce serious infections in the first 100 days. The goal is to see if the lower dose is just as good at preventing graft-versus-host disease (where donor cells attack th…

This study aims to find out if adding a hormone (epoetin alfa) to a cancer drug (lenalidomide) works better than the cancer drug alone to improve severe anemia in patients with a type of bone marrow disorder called low-risk myelodysplastic syndrome (MDS). The main goal is to see …

This study is testing whether adding a drug called veliparib to a standard two-drug chemotherapy regimen works better for treating advanced blood cancers. It involves 25 adults with specific types of leukemia and related disorders that have progressed or are hard to treat. Partic…

This study is testing whether combining two chemotherapy drugs is safe and effective for treating adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) that has come back or hasn't responded to other treatments. The goal is to control the disease, p…

This study is testing a two-drug combination to control chronic myelomonocytic leukemia and related blood cancers. It aims to find the safest, most effective dose and see how well the treatment works. The treatment pairs a targeted drug that seeks out cancer cells with a standard…

This study is testing a combination of three oral chemotherapy drugs for people with high-risk myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) who haven't had prior treatment. The first phase aims to find the safest dose, and the second phase measures how…

This study aims to find the most effective drug combination for treating higher-risk myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML), which are serious blood and bone marrow disorders. Researchers are comparing a standard chemotherapy drug (azacitidine)…

This early-phase study is testing a new antibody drug called bexmarilimab in combination with standard cancer therapies. It aims to find a safe dose and see if the combination helps adults with advanced forms of blood cancers like myelodysplastic syndrome (MDS) and acute myeloid …

This study is testing whether a detailed health assessment can help doctors personalize the intensity of a stem cell transplant for older adults (age 60+) with certain blood cancers. The assessment looks at factors like thinking skills, physical ability, and mood to decide if a p…

This is the first study in people to test a new oral pill called NTX-301. It aims to see if the drug is safe and can help control advanced forms of leukemia and related blood cancers that have come back or stopped responding to other treatments. The study will enroll about 22 adu…

This study is testing a two-drug chemotherapy regimen followed by a donor stem cell transplant for adults with certain blood cancers that are in remission or at high risk. The goal is to see if this approach can better control the disease and prevent it from coming back after the…

This study is testing the safety and effectiveness of combining two drugs, vorinostat and azacitidine, for patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). The goal is to find the best dose and see if the combination can better control the disease by…

This study allows patients with certain blood cancers who were benefiting from ASTX727 treatment in previous trials to continue receiving the medication. The main goal is to collect long-term safety information about the drug. Participants will receive the same dose they were tak…

This early-stage trial is testing whether a combination of two immune-based treatments is safe for patients whose blood cancer has returned after a stem cell transplant. The study involves 25 adults with conditions like acute myeloid leukemia or myelodysplastic syndromes. Researc…

This study is testing if adding a drug called pomalidomide to standard chemotherapy works better for adults newly diagnosed with a specific, harder-to-treat type of acute myeloid leukemia (AML). About 50 participants will be randomly assigned to receive either the standard chemo …

This study is testing if a two-drug oral combination works better than a single oral drug to control symptoms and reduce cancer cells in patients with certain aggressive blood cancers, including chronic myelomonocytic leukemia (CMML). It is a Phase 2 trial with 132 participants, …

This study is testing a combination of three drugs—azacitidine, venetoclax, and pevonedistat—for adults newly diagnosed with certain high-risk blood cancers. These include acute myeloid leukemia (AML) that developed from other blood disorders or prior cancer treatment, as well as…

This study is testing whether the drug ruxolitinib can help control Chronic Myelomonocytic Leukemia (CMML), a rare blood cancer. Researchers are enrolling 29 adults with CMML who have significant symptoms or an enlarged spleen. The main goal is to see if the treatment reduces sym…

This study is testing a new combination of two drugs, guadecitabine and atezolizumab, for adults with advanced myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML). It is for patients whose cancer has returned or stopped responding to standard treatments. The …

This study is testing a personalized plan to manage cytomegalovirus (CMV), a common and potentially serious infection, in patients who have received a donor stem cell transplant for blood cancers or disorders. The plan involves closely monitoring the virus level and the patient's…

This study aimed to understand how severe COVID-19 disrupts the body's production of immune cells, similar to what happens in certain blood cancers. Researchers planned to compare blood cell samples from three groups: severe COVID-19 patients, people with chronic blood cancers, a…