BREAST NEOPLASMS

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with advanced cancers that have stopped responding to standard treatments. The goal is to see if the drug is safe and can help control the cancer. About 350 people with various cancer types, …

This early-phase study tests an experimental drug called LY3484356 in 17 Chinese patients with a specific type of advanced breast cancer (ER+/HER2-). The main goal is to see how the drug moves through the body and how safe it is. Researchers will also check if the drug can shrink…

This early-stage study tested the safety of a drug called abemaciclib when combined with various other breast cancer treatments (like letrozole, tamoxifen, or trastuzumab) in 198 people whose breast cancer had spread to other parts of the body. The goal was to find safe combinati…

This study tests a new drug called BT8009, given alone or with another drug (pembrolizumab), in people with advanced solid tumors like bladder, breast, lung, or ovarian cancer that have not responded to standard treatments. The goal is to see if the drug is safe and can shrink tu…

This study compares a 1-week radiation schedule to the standard 3-week schedule for women with node-positive breast cancer after surgery. The goal is to see if the shorter treatment is just as effective at preventing cancer from coming back while also reducing the risk of lymphed…

This study tests whether adding alpelisib to standard fulvestrant therapy can slow cancer growth in Chinese men and postmenopausal women with a specific type of advanced breast cancer (HR+, HER2-, with a PIK3CA mutation) that worsened after prior hormone therapy. About 69 partici…

This early-stage study tests an experimental drug called AZD6244 combined with standard chemotherapies in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal is to find a safe dose and see how the body handles the drugs. Participants must …

This early-stage study tests an experimental pill, ATV-1601, in people with advanced solid tumors (including certain breast, ovarian, and prostate cancers) that have a specific AKT1 gene mutation. The main goals are to check the drug's safety, find the best dose, and see how the …

This study tests three drugs—durvalumab, olaparib, and cediranib—in different combinations for people with advanced solid tumors, including ovarian, breast, lung, prostate, and colorectal cancers. The goal is to see if these combinations can shrink or control tumors. Participants…

This early-phase study tests a new drug called E7090, alone or with other cancer medicines, in people with a certain type of advanced breast cancer (ER+, HER2-). The main goal is to find safe doses and check for side effects. About 51 participants will take part to help guide fut…

This study tests whether adding a targeted drug (PD 0332991) to standard hormone therapy (anastrozole) can better stop breast cancer cell growth before surgery. It involves 84 women with early-stage ER+ HER2- breast cancer. The goal is to see if the combination leads to more comp…

This phase 3 study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy helps people with a common type of advanced breast cancer (HR+/HER2-) live longer without their cancer getting worse. About 340 participants who have already tried hormone therap…

This study tests whether a combination of two hormone-targeting drugs (ribociclib and letrozole) can work as well as standard chemotherapy when given before surgery for a certain type of breast cancer. The trial involves 100 postmenopausal women with hormone receptor-positive, HE…

This study tests a new hormone therapy called imlunestrant against standard hormone therapy in people with early-stage breast cancer that is ER+ and HER2-. Participants have already had 2 to 5 years of hormone therapy and are at higher risk of their cancer coming back. The goal i…

This study tests whether adding extra immunotherapy before standard treatment can help the immune system better attack triple negative breast cancer. About 12 adults with untreated, locally confirmed TNBC will receive different immunotherapy combinations plus chemotherapy before …

This early-stage study tests a new drug (H3B-6545) combined with a standard drug (palbociclib) in 31 women with advanced ER+ HER2- breast cancer that has spread. The main goal is to find the safest dose and understand side effects. Participants must have already tried other treat…

This study tests whether a newer drug, trastuzumab deruxtecan (T-DXd), given alone or with other drugs before surgery, works better than the standard treatment for people with high-risk HER2-positive early breast cancer. About 927 adults will take part. The main goal is to see if…

This study tests a new drug, PF-07220060, in people with advanced solid tumors (breast, prostate, lung, and others) that have not responded to standard treatments. The drug is given alone or with hormone therapies to see if it is safe and shrinks tumors. About 362 participants wi…

This early-phase study tests the safety of a drug called tucatinib in about 25 Chinese patients with advanced HER2+ breast, stomach, or colorectal cancers that have stopped responding to standard treatments. The main goal is to see what side effects occur and how the drug moves t…

This phase 3 study tested whether adding abemaciclib (a targeted therapy) to standard hormone therapy (fulvestrant) helps women with a common type of advanced breast cancer (HR+, HER2-). About 669 women whose cancer had spread or could not be removed by surgery took part. The mai…

This study tests a shorter, more targeted radiation therapy (accelerated partial breast irradiation) given after breast-conserving surgery in people with early-stage breast cancer. The goal is to see if this approach controls cancer recurrence and reduces side effects compared to…

This study looks at whether contrast-enhanced mammography (CEM) can find breast cancer more accurately than standard mammography in women who have already had breast cancer. About 1,647 women aged 30-85 will get both types of mammograms to compare detection rates and false alarms…

This study compares how well ultrasound and MRI find breast cancer in women with dense breasts who have already had breast cancer. About 1,756 women will get either an ultrasound or an MRI (short or full version) to see which test catches more cancers. The goal is to find the bes…

This study tests a new approach for breast cancer survivors who still have pain long after treatment ends. Instead of just medication, participants learn how the brain processes pain (pain neuroscience education) and slowly increase their activity levels (behavioral graded activi…

This study looked at whether a physical therapy program focused on neck control exercises could help long-term breast cancer survivors (at least 5 years since diagnosis) with neck pain, mood, and quality of life. The program aimed to improve how well participants could control th…

This study reviews medical records of 88 women who had two-stage breast reconstruction after mastectomy for breast cancer. It compares complications between nano- and microtextured tissue expanders and examines how prior radiotherapy affects outcomes. The goal is to understand wh…

This study follows over 1,400 people with a common type of advanced breast cancer (HR+/HER2-) who are receiving standard first-line treatment with palbociclib plus hormone therapy. Researchers are collecting real-world data on how long the cancer stays controlled and overall surv…

This study looks at how invasive breast cancer and its treatments impact the quality of life of 133 patients in Martinique. Researchers will use surveys to understand patients' physical, emotional, and daily challenges, as well as how long treatment takes. The goal is to find way…

This study collects information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers will look at how the cancer was found, what risk factors were present, what treatments were used, and how well patients did over time. The goal is to …

This study surveys 3,000 women aged 40 and older in Chinese communities to find out how many regularly perform breast self-exams and what factors influence their practice. Researchers use a health belief model to identify gaps in awareness and education. The goal is to improve ea…

This study uses tumor and blood samples from 1000 breast cancer patients to create a model that predicts how well immunotherapy will work. Researchers will analyze genes, proteins, and other markers to find patterns that separate responders from non-responders. The goal is to hel…

This study looks at whether certain older women with a specific type of early-stage breast cancer can skip radiation after a lumpectomy. The 202 participants are all postmenopausal, have hormone-positive, HER2-negative tumors, and plan to take hormone therapy. Researchers will fo…

This study looks at whether certain lab-made antibodies can identify breast cancer markers in blood samples. Researchers will collect blood from about 84 people, including breast cancer patients and healthy volunteers. The goal is to improve how we detect cancer cells circulating…

This study collects blood or saliva samples from people with cancer and their relatives to build a DNA bank. Researchers will use these samples to study how genes may increase the risk of developing certain cancers. About 992 participants are expected. No treatment or direct bene…