Breast neoplasms

Researchers are testing an oral drug called AL58805, which blocks two cancer-growth proteins, PI3K and mTOR, in adults with advanced endometrial, cervical, soft tissue sarcoma, or breast cancers that have worsened after at least one standard treatment. Participants receive AL5880…

This trial tests whether a 14-week physiotherapist-led exercise program, given alongside standard pre-surgery treatment for breast cancer, improves physical fitness, muscle strength, quality of life, and the ability to complete treatment. Researchers will compare participants who…

This trial tests whether special augmented-reality goggles can help surgeons find lymph nodes that may be missed during breast cancer surgery. The goggles show a fluorescent dye that collects in lymph nodes, allowing the surgeon to re-examine the area after the planned removal is…

This study tests whether a combination of three drugs—kumorixilib, capecitabine, and letrozole—given before surgery can slow or shrink tumors in people with HR-positive, HER2-negative breast cancer. Participants take the drugs for six 28-day cycles, then have surgery. The main go…

This study looks at the best order to give two powerful antibody-drug conjugates (ADCs) — T-DXd and SG — to people with a common type of advanced breast cancer (HR+/HER2-). After standard hormone therapy stops working, doctors are unsure which drug to use first. The study will en…

Many cancer trials require patients to have specific molecular markers, so researchers test large numbers of people to find the few who qualify. This study evaluates FATHOM, an AI system that reads clinical trial records and routine tumor slides to predict which patients carry th…

Researchers are testing whether an artificial intelligence model can spot breast cancer on chest CT scans that women already receive during routine health exams. The study includes a retrospective phase to validate the AI on existing images and a prospective phase where the AI re…

This study investigates whether offering regular breast ultrasound screening to women aged 65 to 80 can increase the rate of early-stage breast cancer detection compared to routine health check-ups. Over 82,000 women from communities in China will be assigned to either receive st…

This study tests whether augmented-reality goggles, combined with a special dye called indocyanine green (ICG), can accurately identify cancerous lymph nodes during breast cancer surgery. Two hundred adults with breast cancer will take part. The goggles use near-infrared light to…

This study will test if artificial intelligence can create clear breast MRI images without using contrast dye. Researchers will use a special type of MRI scan (diffusion-weighted imaging) to generate synthetic images that might help diagnose breast cancer. If successful, this cou…

This study aims to see if a less invasive biopsy method, using ultrasound guidance, can accurately detect whether breast cancer has spread to nearby lymph nodes. Researchers will enroll 200 adults with newly diagnosed breast cancer. The goal is to find the best way to identify su…

This pilot trial tests a community-based program designed to help Chinese immigrants aged 45-75 get up-to-date on colorectal and breast cancer screening. The program includes a group education session led by a community health worker and personalized help navigating the healthcar…

Researchers are testing whether a 12-week supervised dance-based exercise program can reduce cancer-related fatigue in women with newly diagnosed breast cancer who are having treatment before surgery. The study includes 104 women aged 18 to 60 who will be randomly assigned to eit…

This study is testing a smartphone-based system that gives personalized advice to breast cancer patients going through chemotherapy. The system uses a knowledge graph to combine medical guidelines and patient-reported symptoms. Thirty patients and their nurses will use the system…

This study aims to find the best combination of three support strategies—priority coaching, education, and guided goal-setting—to help people who finished early-stage breast cancer treatment return to work, social life, and daily activities. About 352 participants will try one of…

This study tests a program called AIMSS-CARE for breast cancer patients who have joint and muscle pain from their hormone therapy. The program includes exercise, education, symptom tracking, and follow-up. Eighty-eight patients in Ethiopia will be randomly assigned to the program…

This study tests whether listening to positive self-affirmation audio recordings can help reduce pain, depression, anxiety, and stress in women who have had a mastectomy. Forty-two women will be randomly assigned to either listen to the affirmations or receive standard care. The …

This study tests whether a special skin-like sheet (SureDerm) placed during breast-conserving surgery can improve how the breast looks and feels afterward. About 116 women with breast cancer will be randomly assigned to get the implant or standard surgery alone. Researchers will …

This study will send different types of WhatsApp messages to 235,000 people in Chile who are due for cancer or chronic disease screenings. Researchers want to see if the way a message is worded (basic, risk-focused, or peace-of-mind) and whether it mentions one test or both tests…

This study tests whether a special education program can increase breast and cervical cancer screening among visually impaired women. About 74 women over age 40 will receive training on cancer risks and how to schedule screenings. Researchers will check if screening rates and kno…