AORTIC STENOSIS

This study tests a new way to choose the right valve size for people with a specific type of heart valve disease (bicuspid aortic stenosis) who need a valve replacement procedure called TAVR. About 290 participants will have their CT scans analyzed using the ABC Bicuspid Sizing A…

This study compares early valve replacement (surgery or TAVI) versus watchful waiting in people with severe aortic stenosis who have no symptoms. About 2,844 adults over 18 with severe but asymptomatic aortic stenosis will be followed for at least 3 years. The goal is to see if e…

This study tests a monthly injection called pelacarsen to see if it can slow the worsening of a heart valve condition called aortic stenosis. The valve becomes stiff and narrow due to calcium buildup, making it harder for the heart to pump blood. The trial includes 502 adults age…

This study compares two approaches for people with severe aortic stenosis who go into cardiogenic shock (the heart can't pump enough blood). One group gets a new heart valve within 12 hours; the other gets standard ICU care and the valve later. The goal is to see if immediate tre…

This study compares two newer heart valve devices (Evolut FX and Sapien 3 Ultra Resilia) in 1346 people with aortic stenosis, a condition where the heart's main valve narrows. Participants are randomly assigned to get one of the two valves. The main goal is to see if one valve is…

This study tests a new way to replace a narrowed heart valve (aortic stenosis) using a tube inserted through the armpit, guided only by ultrasound instead of X-rays. About 20 people with severe symptoms will be enrolled to see if this approach is safe and works well. If successfu…

This study is for people with aortic stenosis whose first transcatheter heart valve has failed and needs to be replaced. Researchers want to see if a second, minimally invasive valve replacement (redo TAVR) is safe and works well. About 225 participants will be followed for one y…

This study tests a new device called the Siegel TAVR system to replace a narrowed heart valve in people with severe aortic stenosis. About 1,025 participants with symptoms like chest pain or shortness of breath will receive the procedure. The goal is to see if the device reduces …

This study tests whether artificial intelligence can make a standard electrocardiogram (ECG) better at finding two common heart conditions: aortic stenosis and diastolic dysfunction. Researchers at Mayo Clinic will enroll 2000 adults aged 60 and older who are already scheduled fo…

This study tests whether an artificial intelligence (AI) program can spot aortic stenosis—a narrowing of the heart's main valve—by analyzing a simple electrocardiogram (ECG). Researchers will compare the AI's results with standard diagnosis in 5,000 adults. If successful, this co…

This study tests an artificial intelligence (AI) tool to help doctors accurately diagnose severe low-gradient aortic stenosis, a heart valve condition that can be hard to detect. Researchers will enroll 300 adults with suspected disease and compare the AI's analysis of standard e…

This study looks at whether using shockwave therapy on the leg artery before a heart valve replacement (TAVR) can lower the risk of bleeding and other complications. About 100 people with severe aortic stenosis and heavily calcified arteries will take part. The goal is to make th…

This study looks at whether it is safe to temporarily stop taking beta-blockers (heart medications) in patients who are about to have a procedure to replace a narrowed heart valve (TAVR). About 500 adults with severe aortic stenosis will be randomly assigned to either stop or con…

This study will use wearable digital patches to collect heart data from 5,000 adults with conditions like heart failure, high blood pressure, and heart valve disease. The goal is to observe how these conditions change over time for research purposes. Participants wear a sensor pa…

This study aims to find early signs of scarring (fibrosis) in the heart muscle of people with aortic stenosis, heart damage from chemotherapy, or carcinoid syndrome. Researchers will use special PET scans to see active scarring. The goal is to better understand and detect these c…

This study watches how aortic stenosis (a heart valve disease) develops and changes over time, even after valve replacement. About 300 people over age 50 with mild to severe disease will get heart scans every 6 months to track calcium buildup, scarring, and inflammation. The goal…

This study looks at whether artificial intelligence (AI) can help heart doctors read echocardiograms (heart ultrasounds) more quickly and consistently. Researchers will give AI analysis to cardiologists in real time as they review scans for valve problems like aortic stenosis and…

This study looks at whether fixing a tight heart valve with a procedure called TAVI can improve the balance of bacteria in the gut. Researchers will collect stool and blood samples from 40 patients before and after the procedure to see if better blood flow changes gut health. The…

This study compares two heart imaging methods—echocardiography (ultrasound) and cardiac MRI—to see how well they measure heart valve problems and heart function. Researchers will enroll 200 adults with suspected moderate to severe valve disease. No treatment is given; the goal is…

This study aims to find biological markers (signs in the blood) that can identify which patients with aortic stenosis are at higher risk of heart problems. Researchers will collect blood samples and health information from 125 patients with different stages of aortic stenosis. Th…

This early study looks at whether a non-invasive test called impedance cardiography (the HYPERGRAPH test) can detect early signs of heart strain in people with aortic stenosis, a condition where the heart's main valve narrows. Researchers will compare the test results with MRI sc…

This study is looking at whether certain substances in the blood (markers of inflammation and scarring) can help predict if a person will develop heart rhythm problems after a TAVI procedure to replace a narrowed heart valve. About 102 people with severe aortic stenosis who are s…

This study aims to identify biological differences between men and women with heart valve disease (aortic regurgitation, mitral regurgitation, or aortic stenosis) using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe valve disease to develop se…