AORTIC STENOSIS

This study looks at nearly 1,000 people with severe aortic stenosis (a narrowed heart valve) and blocked heart arteries. It compares two approaches: opening the blocked arteries before or after replacing the heart valve. The goal is to see which timing leads to fewer deaths, hear…

This study tested a new artificial heart valve (Model 400 Avalus) in 1312 people with aortic valve disease, such as narrowing or leaking. The goal was to see if the valve is safe and works well by checking heart function and blood flow for up to one year after surgery. Participan…

This study compares two ways to replace a narrowed heart valve in patients 65 and older: a less invasive procedure (TAVR) versus open-heart surgery. The goal is to see which method works better for people with small valve openings, focusing on how well the new valve functions and…

This early study tests a new device called DurAVR™ THV to replace a narrowed heart valve in people with severe aortic stenosis. The goal is to see if the procedure is safe and feasible in 15 patients aged 65 or older. The device is delivered through a leg artery, avoiding open-he…

This study tested a new replacement heart valve (ACURATE) in nearly 2,000 people with severe aortic stenosis, a condition where the heart's main valve narrows and restricts blood flow. The goal was to see if the device was safe and effective at improving survival and reducing com…

This study tests a new, less invasive heart valve (SAPIEN 3) for people with severe aortic stenosis who are at low risk for standard surgery. About 1,000 participants will be randomly assigned to get the new valve or traditional open-heart surgery. The goal is to see if the new v…

This study compares a newer, less invasive procedure called TAVR (replacing the heart valve through a tube) with traditional open-heart surgery for people with severe narrowing of a bicuspid aortic valve. About 452 participants aged 75 or younger will be randomly assigned to one …

This study tests whether artificial intelligence (AI) can help detect aortic stenosis, a narrowing of the heart valve, in people aged 70 and older during routine clinic visits. Participants will have a portable ECG and heart ultrasound, and AI will analyze the results to see if i…

This study is collecting information from 800 people with severe aortic stenosis who are scheduled for a TAVI procedure. Researchers want to see if there are differences in heart anatomy and blood test results between people from different countries. The goal is to better underst…

This study looks at how well a heart valve replacement procedure (TAVR) works in Asian patients who have a smaller-than-average heart valve opening. About 31 people from different Asian backgrounds will be followed for one year to compare two types of artificial valves. The goal …

This study tests a digital score to monitor aortic stenosis, a heart valve condition, in 210 adults aged 65 and older with early signs of the disease. Researchers will track changes in heart function over time using data from routine tests. The goal is to improve risk prediction,…