AORTIC STENOSIS

This study tested if closing a small heart pouch (left atrial appendage) with a device is safer and as effective as standard blood thinners for preventing strokes in people with atrial fibrillation who are also getting a new heart valve. About 80 participants were randomly assign…

This study looked at how safe and effective the SAPIEN 3 heart valve is for Chinese patients with severe aortic stenosis (a narrowed heart valve) who are too high-risk for open-heart surgery. Fifty-eight patients received the valve through a less invasive procedure called TAVI. T…

This study looked at whether a new way of processing heart valves (made from cow tissue) is safe and works well for people who need a new aortic or mitral valve. About 777 adults took part, and researchers checked for valve problems and side effects up to 5 years after surgery. T…

This study tested two new heart valves (Portico and Navitor) in 30 Indian patients with severe aortic stenosis who were at high risk for surgery. The goal was to see if the valves were safe and worked well. Researchers tracked complications, valve function, and quality of life fo…

This study tested a device called ShortCut in 8 people who needed a second heart valve replacement inside an old one. The device splits the old valve leaflets to prevent them from blocking the heart arteries. The goal was to see if the device is safe and works as intended.

This study tested whether colchicine, an anti-inflammatory drug, can slow the buildup of calcium in the aortic valve in people with mild-to-moderate aortic stenosis. 24 adults were randomly assigned to take colchicine or a placebo for 6 months. The main goal was to see if the dru…

This study looked at how heart devices and treatments affect a blood protein called von Willebrand factor, which helps blood clot. Researchers studied 500 adults with advanced heart failure or aortic stenosis to understand when and why bleeding problems happen. The goal was to le…

This study looked at 116 people with severe aortic stenosis (a narrowed heart valve) and moderate coronary artery blockages. Researchers measured blood flow in the heart arteries before, right after, and 6 months after valve replacement surgery. The goal was to understand how the…

This study looked at whether replacing a narrowed heart valve (TAVR) can improve thinking and memory in 81 adults with mild cognitive impairment. Researchers tested participants with a 5-minute quiz before the procedure and again at 30 days and 6 months after. The goal was to see…