AORTIC STENOSIS

This study will check if a special heart valve replacement (SAPIEN 3) works well and is safe for people with a rare type of aortic valve disease called Type-0 bicuspid valve. About 170 people in China will take part. The goal is to see if the valve helps reduce death, stroke, or …

This study will follow 500 adults with severe aortic stenosis who receive a new type of heart valve (SAPIEN 3 Ultra Resilia) through a minimally invasive procedure. Researchers will track how well the valve works and how safe it is over 10 years. The goal is to understand the val…

This study tests if using a second balloon inflation (called 'double tap') right after placing a new heart valve can help the valve open more fully. The trial will include 250 adults with severe aortic stenosis who are getting a TAVI procedure. Researchers will compare standard T…

This study looks at whether a procedure to replace a narrowed heart valve (TAVI) is safe when done in a hospital that does not have emergency heart surgery available. Currently, the standard is to have this procedure only where surgery is on-site. About 600 people with severe aor…

This study looks at whether a common heart valve replacement called TAVI can be safely performed in hospitals that do not have a cardiac surgery department on site. Currently, TAVI is only done in hospitals with full surgical backup, which can cause long wait times. The trial wil…

This study tests whether two heart failure medications, dapagliflozin and spironolactone, can help the heart recover more fully after aortic valve replacement. About 445 adults with severe aortic stenosis will take one or both drugs daily for 12 months after their valve surgery. …

This study tests a new device called the EmStop Embolic Protection System, designed to capture and remove debris that may break loose during a minimally invasive heart valve replacement (TAVR) for aortic stenosis. About 663 people will be enrolled to see if the device reduces the…

This study tests whether using only ultrasound (echo) to guide a minimally invasive heart valve replacement is as effective as the standard method that uses both X-ray and ultrasound. The goal is to reduce the risk of kidney damage from contrast dye and lower radiation exposure f…

This study tests two common ways to place a new heart valve (TAVI) to see which one avoids blocking the heart's own arteries. About 40 people with severe aortic stenosis will be randomly assigned to one of the two techniques. A CT scan after the procedure will check how well the …

This study looks at how common cardiac amyloidosis (a protein buildup in the heart) is in people with aortic stenosis (a narrowed heart valve). Researchers will follow 143 patients getting a valve replacement to compare those with and without the protein buildup. The goal is to l…

This observational study looks at whether advanced heart pressure wave measurements can help predict how well people recover after a TAVR procedure for severe aortic stenosis. Researchers will measure pressure waves during the standard procedure and track patients' quality of lif…

This study is a registry that will collect information on 600 people with severe aortic stenosis who cannot have the usual TAVI procedure through the leg artery. Instead, they will receive the valve through other blood vessels. The goal is to observe and record how safe and effec…