ANEMIA

This study looks at whether giving iron supplements to anemic patients before major heart surgery can improve their long-term quality of life, sleep, and fatigue. About 400 adults with iron-deficiency anemia scheduled for heart surgery will be randomly assigned to receive iron or…

This study tests whether giving an intravenous iron supplement before weight-loss surgery can prevent anemia and improve quality of life in obese patients with low iron levels. About 200 participants will receive either the iron infusion or a placebo before their surgery. The goa…

This study tests an experimental drug called DISC-0974 in about 150 adults with myelofibrosis or myelodysplastic syndrome who also have anemia. The goal is to see if the drug is safe and can help patients need fewer or no blood transfusions. The study is in early to mid stages an…

This study tests a drug called luspatercept for people with alpha-thalassemia, a blood disorder that causes anemia. The goal is to see if it can reduce the need for blood transfusions and raise hemoglobin levels. About 189 adults and teens will take part. The drug is given as a s…

This study tests two oral iron treatments, Sucrosomial® Iron and Ferric Maltol, in 146 women with mild to moderate iron deficiency anemia. Participants take one of the two supplements for 12 weeks to see which is better at raising hemoglobin levels and is easier on the stomach. T…

This study tests whether using smaller tubes to draw blood from anemic patients in the intensive care unit (ICU) can reduce the need for red blood cell transfusions. About 688 adults with low hemoglobin will be randomly assigned to have blood drawn with either small or standard-s…

This study tests a new drug called elritercept against a standard treatment (epoetin alfa) for anemia caused by a bone marrow disorder called myelodysplastic syndromes (MDS). About 300 adults who need regular red blood cell transfusions will take part. The goal is to see if elrit…

This study tests whether a special type of iron supplement (Sucrosomial iron) helps children with newly diagnosed celiac disease and low iron or anemia recover faster than just following a gluten-free diet alone. About 60 children aged 8-18 will receive either the iron supplement…

This study tests the drug luspatercept in 50 adults with clonal cytopenias of uncertain significance (CCUS), a condition where blood cell counts are low and there is a risk of developing blood cancer. Participants receive injections every three weeks for up to 48 weeks. The goal …

This study looks at whether opening blocked leg arteries within 48 hours (early angioplasty) helps heal foot ulcers faster in people with type 2 diabetes compared to waiting for a scheduled procedure. Researchers will track wound healing with a 3D camera and study how the wound's…

This early-stage study is testing a new drug called APG-5918 to see if it is safe and can help people with anemia, a condition where the body lacks enough healthy red blood cells. The study includes both healthy volunteers and anemic patients, and will measure side effects, drug …

This study looks at adults with advanced myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) who are receiving palliative care. Instead of giving blood transfusions based only on a fixed hemoglobin level, researchers will use a quality-of-life questionnaire to decide …

This study tests whether a single dose of intravenous iron can help elderly patients recover their ability to walk after hip fracture surgery. Researchers will compare iron to a placebo in 210 patients aged 65 and older who have low iron levels after surgery. The goal is to see i…

This study tests an experimental drug called DISC-0974 for people with inflammatory bowel disease (IBD) who also have anemia (low red blood cells). About 21 adults with mild IBD and anemia will receive either the drug or a placebo. The main goal is to see if the drug safely raise…

This study looks for unknown genetic causes of congenital sideroblastic anemia, a rare blood disorder where the body cannot properly use iron to make red blood cells. Researchers will analyze DNA from 20 participants to find new genes linked to the condition. The goal is to bette…

This study tests whether training mothers to measure their child's upper arm with a simple tape can catch malnutrition early and prevent relapse. About 2,400 children who recovered from severe acute malnutrition will take part. Some mothers will check their child weekly and follo…

This study looks at how closely doctors follow a new hospital guideline for managing anemia (low red blood cells) in patients before major surgery. About 93 anemic patients will be tracked to see if the guideline is used correctly and if it helps reduce blood transfusions, hospit…

This study looks at how a blood transfusion changes heart function in older anemic patients in the emergency room. Researchers will use ultrasound to check the heart before, right after, and 15 minutes after the transfusion. The goal is to see which heart measurements change the …

This study tests a set of tools designed to help primary care doctors diagnose the causes of low hemoglobin (anemia) and low kidney function more accurately and quickly. About 450 patients and their doctors from 13 clinics will take part. The goal is to see if these tools improve…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and checking for conditions like diabetes, high blood pressure,…

This study looks at 236 adults with severe heart failure who need a heart-lung machine (ECMO). It compares two ways of deciding when to give blood transfusions: one based on a standard hemoglobin level, and another based on how much oxygen is in the blood. The goal is to see whic…

This study is a registry that will follow 200 people in Germany with myelofibrosis and anemia. It will collect information on which treatments are used, how well they work, and how patients feel. The goal is to better understand current care and outcomes, not to test a new drug.

This study is following 2,800 pregnant women and their children in Weifang, China, to learn how things like diet, lifestyle, and environment before and during pregnancy affect the health of both mother and child. Researchers will track health issues like diabetes, high blood pres…

This study uses a special type of MRI (called 129Xe gas exchange MRI) to take detailed pictures of how the lungs and heart work together. Researchers want to see if these images can help measure lung function in people with conditions like lung scarring, blood clots in the lungs,…

This study looks at 1000 adults having moderate- to high-risk surgery to see if the type of anemia they have before surgery affects their chance of complications like heart injury, kidney injury, or stroke. Researchers will compare people with iron-deficiency anemia, anemia from …

This study looks at whether Cambodia's health system is ready to give pregnant women a new type of vitamin that includes more nutrients than just iron and folic acid. Researchers will talk to healthcare workers, survey 630 pregnant women, and check vitamin supplies to find gaps a…

This study looks at how well adults with chronic conditions like inflammatory bowel disease, high blood pressure, anemia, or multiple sclerosis accept and stick with two dietary supplements (Goodphyte IB Defense and Goodphyte Immunity). The supplements contain a natural enzyme th…

This study is building a registry of up to 900 people with Diamond Blackfan anemia (DBA), a rare inherited bone marrow condition that causes low red blood cells. Researchers will collect medical information and genetic data to learn more about how DBA develops and affects patient…

This study looks at how well malnourished children absorb iron from ready-to-use therapeutic foods. Researchers will compare healthy children to those with severe or moderate acute malnutrition to see if too much iron causes problems like diarrhea. The goal is to create a safer, …