ANEMIA

This study tests a drug called luspatercept in adults with lower-risk myelodysplastic syndromes (MDS) or related blood disorders who have anemia. The goal is to see if it can reduce the need for regular blood transfusions. Six participants will receive the drug along with standar…

This study tests the safety and effectiveness of luspatercept in 85 adults with anemia due to myelodysplastic syndromes (MDS) or beta-thalassemia who need regular red blood cell transfusions. The goal is to see if the drug can reduce the number of transfusions needed. Participant…

This study tests a new drug (INCB000928) given alone or with ruxolitinib for people with myelofibrosis who have anemia or need regular blood transfusions. The goal is to find a safe dose that improves red blood cell counts and reduces transfusion needs. About 84 adults will take …

This study looks at how well a new iron supplement made from fish (SalmoFer®) is absorbed by the body and whether it causes stomach discomfort. It involves 61 women aged 21 to 42 with low iron or mild anemia. Participants take the supplement and have blood tests to measure iron l…

This study aimed to test a radioactive drug, 177Lu-PSMA-617, in men with advanced prostate cancer that had spread to the bone marrow and caused low blood counts. The goal was to see if the treatment was safe and how it affected the cancer. However, the study was withdrawn before …

This study tested whether a combination of ibrutinib (a targeted pill) plus rituximab works better than standard chemotherapy (FCR) for younger patients with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 529 people took part. The main goa…

This study tests whether adding epoetin alfa to lenalidomide helps people with myelodysplastic syndrome (MDS) and anemia better than lenalidomide alone. About 247 adults with low- or intermediate-risk MDS and low red blood cell counts took part. The main goal was to see if the co…

This program provided HBOC-201, a blood substitute made from cow hemoglobin, to adults with life-threatening anemia who could not receive blood transfusions. The treatment aims to deliver oxygen to tissues when blood is not an option. Participants had very low hemoglobin levels a…

This study looks at whether a hormonal IUS or birth control pills with iron better improve anemia in women with mild to moderate anemia who want contraception. About 405 women in Kenya will be followed for 12-18 months. The main goal is to see which method raises hemoglobin level…

This study tests whether treating red blood cells with the INTERCEPT Blood System can safely reduce the risk of Zika virus transmission during transfusions. About 692 patients who need blood transfusions will receive either treated or standard red blood cells. The main goals are …

This study tests whether a school-based program including meals, nutrition education, vegetable gardens, iron supplements, and deworming can reduce anemia and underweight in adolescents aged 14-17 in Tanzania. About 1,500 teens and their mothers from six schools will take part, w…

This study looks at whether giving vitamin B12 supplements to pregnant women at risk of deficiency can improve their children's growth and thinking skills. About 800 pregnant women in South Asia will take either a daily B12 pill or a placebo from early pregnancy until 6 months af…

This study tests whether a low dose of the drug pazopanib, taken daily for 24 weeks, can reduce the severity and duration of nosebleeds in people with hereditary hemorrhagic telangiectasia (HHT), a condition that causes frequent bleeding. About 70 participants will receive either…

This study aimed to see if holistic education could help people manage stress and related conditions like anxiety, fatigue, and PTSD. It was designed for unmarried Alaska Medicaid recipients aged 22 and older who agreed to a smoke-free, drug-free, and alcohol-free lifestyle. The …

This study follows 1,304 healthy children aged 8 to 10 in rural India to track their growth, bone strength, and muscle health over time. Researchers aim to understand how nutrition and behavior during early adolescence influence lifelong health and break the cycle of malnutrition…

This study looks at whether taking daily vitamin D or fish oil supplements can lower the chance of developing anemia in older adults. Researchers are following 2,000 people who are already part of a larger heart and cancer study. They will compare anemia rates between supplement …

This study tests a tablet-based decision support tool called mIRA that helps frontline health workers provide better antenatal care. It focuses on detecting and managing gestational diabetes, pregnancy-induced high blood pressure, and anemia. About 1,320 pregnant women in India a…

This study looks at how anemia (low red blood cells) and blood transfusions affect oxygen levels in the digestive tract of extremely low birth weight babies (≤1250 grams). Researchers will monitor oxygen in the gut and analyze blood, urine, and stool to find clues that might pred…

This study looks at how a program that helps families escape poverty affects the development of children aged 0-9 in Uganda. Researchers will compare kids from families who got the program to those who didn't, checking things like growth, anemia, and school readiness. No new trea…

This study reviews medical records of 85 adults with chronic heart failure to see if SGLT2 inhibitors (a type of diabetes drug) improve red blood cell production and heart/kidney function over 12 months. Researchers compare those who started the drug to a similar group who did no…