ALCOHOL USE DISORDER (AUD)

This phase 2 trial tests whether moderate to high doses of LSD can reduce heavy drinking in people with alcohol use disorder. 128 participants who have recently detoxified will receive either LSD or a low-dose placebo, along with therapy. The study tracks drinking behavior and br…

This study tests whether adding a smartphone app to standard medication helps Veterans with alcohol use disorder drink less heavily. About 330 Veterans will either get medication alone or medication plus the app. The goal is to see if the app makes treatment more effective and ea…

This pilot study is testing whether semaglutide, a drug used for diabetes and weight loss, can help people with HIV reduce their alcohol use. Thirty participants will receive the drug along with support from a pharmacist and psychiatrist. The goal is to see if the approach is pra…

This study tests whether a single dose of ketamine, combined with real-time brain training (neurofeedback), can help people with alcohol use disorder drink less. 75 participants will receive either ketamine or placebo, plus real or fake neurofeedback. The goal is to see if the co…

This early-stage study tests whether the psychedelic DMT, combined with talk therapy, can help people with alcohol use disorder drink less. About 63 adults with the condition will receive either DMT or a placebo in a controlled setting. The main goals are to check safety and see …

This study tests whether deep transcranial magnetic stimulation (TMS) can help Veterans with alcohol use disorder reduce relapse. About 100 participants will receive TMS targeting brain circuits linked to craving and emotional processing. The goal is to increase alcohol-free days…

This study tests whether suvorexant, a medicine used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. About 180 adults (ages 18-75) with AUD and healthy volunteers will take either suvorexant or a placebo daily…

This study tests a non-invasive brain stimulation technique called theta burst stimulation (TBS) to see if it can reduce heavy drinking and the brain's response to alcohol-related images. About 86 adults with alcohol use disorder will receive either real or fake TBS over the fron…

This study tests whether a drug that blocks alpha-1 receptors can help people with alcohol use disorder drink less and feel less craving. About 184 adults who want to cut back or quit drinking will take the drug or a placebo and report their drinking and cravings. The goal is to …

This study tests a smartphone app called STAR that uses machine learning to send personalized messages to people recovering from alcohol use disorder. The goal is to see if these messages can help people stay engaged in recovery and reduce heavy drinking. About 416 participants w…

This study tests a smartphone app designed to help teens and young adults (ages 14-35) with alcohol or cocaine use disorder. The app provides short training sessions to strengthen self-control when faced with substance-related cues. Researchers want to see if this approach is pra…

This early-stage study tests whether diclofenac, an FDA-approved painkiller, can reduce alcohol cravings in people with alcohol use disorder. Researchers believe diclofenac may work by shifting brain chemistry away from harmful effects of alcohol. The study involves 24 adults who…

This early-phase study tests whether a sublingual form of dexmedetomidine (BXCL501) is safe and shows promise for treating alcohol use disorder in people who also have PTSD. Ten heavy drinkers with PTSD will take the drug and be monitored for changes in blood pressure, anxiety, a…

This study is creating and testing a short, online therapy program for LGBTQ+ people who have experienced trauma and drink alcohol. In the first phase, participants share their thoughts to make the program more helpful and welcoming. In the second phase, some participants can try…

This pilot study tests whether tirzepatide, a drug used for diabetes, can help reduce cravings for alcohol in people with alcohol use disorder. Twenty adults will receive weekly injections of either the drug or a placebo for 4 weeks. The goal is to see if the drug lowers cue-trig…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their lifetime experiences with conditions like depression, …

This study looks at whether tirzepatide, a drug used for diabetes and weight loss, can change how the brain responds to alcohol-related cues in people with alcohol use disorder (AUD). Researchers will use brain scans to measure dopamine activity in healthy volunteers and people w…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…