ALCOHOL USE DISORDER (AUD)

This small pilot study will test whether adding ketamine to cognitive behavioral therapy (CBT) is safe and feasible for people with both alcohol use disorder and major depression. Twenty participants will receive three ketamine injections over six weeks along with CBT sessions. T…

This Phase 3 trial tests a naltrexone implant placed under the skin to help people with moderate to severe alcohol use disorder drink less. About 240 adults will receive either the implant or a placebo, plus counseling. Researchers will track heavy drinking days over 24 weeks to …

This study looks at whether adding a mobile app to a nurse-led counseling program helps men with alcohol use disorder stay sober longer. About 74 men aged 18-59 who own an Android phone will take part. The goal is to see if the app reduces relapse rates over three months compared…

This study tests whether a natural supplement called OEA can reduce inflammation, improve brain function, and lower alcohol use in young adults aged 18-25 with alcohol use disorder. Participants will take OEA or a placebo for 6 weeks and provide blood, saliva, and urine samples. …

This study tests whether a weekly injection of tirzepatide (a diabetes drug) plus cognitive-behavioral therapy can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking days. 46 participants will receive either the drug or a placebo shot for 8 week…

This study tests whether internet-based programs can prevent alcohol use disorders in people who are not currently seeking help. About 3,500 adults with risky drinking habits will be randomly assigned to receive online brief advice, unguided online therapy, or guided online thera…

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce alcohol withdrawal symptoms and cravings in people with moderate-to-severe alcohol use disorder. 105 adults will stay in a hospital for 5 days, receive either CBD or a placebo alongside standard care…

This small pilot study tests whether high-intensity alternating current stimulation on the scalp can reduce cravings and drinking urges in people with alcohol use disorder. Eighteen adults aged 18-60 will receive the stimulation and report changes in craving and drinking behavior…

This study tests a two-session Zoom program called Deaf CBT-TS for Deaf adults who have untreated depression, anxiety, PTSD, insomnia, or alcohol problems. The goal is to change negative beliefs about treatment and encourage them to seek professional help. Researchers will also c…

This study compares psychological processes and emotional symptoms between 200 adults with alcohol use disorder and a healthy control group. Participants fill out questionnaires about their thinking patterns, mood, and anxiety. The goal is to better understand the mental factors …

This study looks at how urban environmental factors like air pollution, noise, and lack of green space affect people with depression, anxiety, or alcohol use disorder. Researchers will use wearable devices and a mobile app to track participants' real-time stress and health data. …