ACUTE RESPIRATORY FAILURE

This study is testing a new device called EMILY that uses artificial intelligence to automatically give the right amount of oxygen to patients with breathing failure. It also watches for signs of worsening and alerts the medical team. The study will include 20 adults in the hospi…

This study compares two methods (waveform capnography and colorimetric carbon dioxide detection) to confirm that a breathing tube is correctly placed in the windpipe of critically ill adults. About 1,332 patients in emergency rooms or intensive care units will be enrolled. The go…

This study looks at whether a quick ultrasound of a large vein (the inferior vena cava) can help emergency doctors figure out why a patient is having sudden trouble breathing. The goal is to tell apart fluid in the lungs from heart problems versus other causes. Researchers will e…

This study explores whether virtual reality (VR) can help patients in the intensive care unit (ICU) feel more relaxed, improve their mood, and keep their minds active. About 32 adults with acute respiratory failure or sepsis will use VR for 15–45 minutes each day for up to 5 days…

This study looks at how the type of oxygen monitor and the target oxygen level affect the amount of oxygen given to ICU patients on high-flow nasal oxygen therapy. Researchers will test two different oximeters and two oxygen targets in 30 adults to see which combination leads to …

This study observes 325 adults with acute respiratory failure who are using non-invasive breathing support like high-flow oxygen or a mask ventilator. Researchers will track health data to see which patients need a breathing tube or die, aiming to find early warning signs. The go…

This study looks at how the brain and lungs interact in adults with sudden breathing failure who are given high-flow oxygen through nasal prongs. Researchers will use EEG and NIRS to measure brain activity and muscle signals before and after starting oxygen. The goal is to unders…

This study tests whether a common substance, sodium bicarbonate (baking soda), can be used as a safe contrast agent to create images of lung blood flow using a bedside imaging method called electrical impedance tomography (EIT). About 41 adults on breathing machines in the ICU wi…

This study compares two types of blades used with video laryngoscopes (a camera-guided breathing tube tool) in ICU patients who need a breathing tube. The goal is to see which blade helps doctors insert the tube successfully on the first try. About 1,036 adults in intensive care …

This study uses a non-invasive monitoring technique called electrical impedance tomography (EIT) to see how air is distributed in the lungs of children with acute respiratory failure in the pediatric intensive care unit (PICU). Researchers will observe how changes in ventilator s…

This study is testing a new device called the MiniLung petite kit in 20 newborns and children weighing 2 to 8 kilograms who have severe breathing or heart failure. The device is used with a machine that takes over the work of the lungs and heart (ECMO). Researchers want to see if…

This study tests a new imaging technique called electrical impedance tomography (EIT) to measure how air and blood flow in the lungs of children with acute breathing failure. The researchers will inject a small, weight-adjusted amount of salt solution to see if it safely and effe…

This study collects small breath and blood samples from 200 intensive care patients who are on breathing machines. Researchers will analyze the proteins in the breath and compare them with DNA, RNA, and other markers in the blood. The goal is to find patterns that signal differen…

This study looks at adults who survived acute respiratory failure (ARF) and the family members or friends who help them after they come home. Researchers want to see if what survivors and their caregivers expect from recovery is linked to their mental health. About 235 pairs will…

This study is collecting information from 250 adults to develop an artificial intelligence model that can identify different types of acute respiratory failure. The goal is to help doctors personalize treatments for this serious breathing condition. Participants include those in …