ACUTE RESPIRATORY FAILURE

This study follows 1756 adults who received either ketamine or etomidate during emergency breathing tube placement in the ICU or ER. Researchers want to see if ketamine can reduce PTSD symptoms one year later, since PTSD is common after such traumatic experiences. Participants co…

This study observes how doctors, patients, and families use time-limited trials (TLTs) for people in the ICU who need a breathing machine. A TLT is a shared plan to try ICU treatments for a set time, then check if the patient is recovering. The goal is to find the best way to use…

This study compares two video laryngoscope blades (hyperangulated vs standard) in critically ill adults who need a breathing tube in the emergency department or intensive care unit. About 2,500 participants will be randomly assigned to one blade type. The main goal is to see whic…

This study compares different training methods for ICU staff to improve how they remove breathing tubes from patients with respiratory failure. Over 13,000 adults on ventilators for more than 24 hours will be included. The goal is to see if team-based training or using a clinical…

This study tests whether using a personalized oxygen target for each patient on a breathing machine leads to better outcomes than standard care. Researchers will use a computer model to predict the best oxygen level for each person. The goal is to see if this approach reduces dea…

This study looks at whether using a smaller or larger breathing tube during emergency intubation affects how patients feel months later. About 3,180 critically ill adults in the ER or ICU will be randomly assigned to get a smaller or larger tube. Researchers will check for breath…

This study looks at whether a special imaging technique called Electrical Impedance Tomography (EIT) can help doctors know if high-flow oxygen therapy will stop working within 48 hours. About 90 adults with acute breathing problems will be monitored. The goal is to find a better …