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Which blade is best? large trial tests emergency intubation tools

NCT ID NCT07223762

Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 10, 2026 · Updated 3 times

Summary

This trial compares two types of video laryngoscope blades—hyperangulated and standard geometry—in critically ill adults who need a breathing tube in the emergency department or intensive care unit. About 2,500 participants will be randomly assigned to one blade type. The main goal is to see which blade leads to successful tube placement on the first try, with a secondary focus on preventing low oxygen levels during the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
video laryngoscope blade (hyperangulated or standard geometry)
What this could lead to
If it works, this could help doctors choose the best tool for placing breathing tubes in emergency situations, potentially improving success rates and reducing complications.
What could go wrong
This is a device comparison study, not a new drug or cure. Results may not apply to all patients or settings, and the study is not blinded, which could introduce bias.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 2,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. Patient is located in a participating unit. 2. Planned procedure is orotracheal intubation using a laryngoscope. 3. Planned operator is a clinician expected to routinely perform tracheal intubation in the participating unit. Exclusion Criteria: 1. Patient is known to be less than 18 years old. 2. Patient is known to be pregnant. 3. Patient is known to be a prisoner. 4. Immediate need for tracheal intubation precludes safe performance of study procedures. 5. Operator has determined that use of a direct laryngoscope is required for the optimal care of the patient. 6. Operator has determined that use of a hyperangulated video laryngoscope blade or a standard geometry video laryngoscope blade is required or contraindicated for the optimal care of the patient either because of factors related to the patient (e.g., patient's upper airway anatomy requires a specific blade type) or the operator (e.g., treating clinicians lack sufficient comfort with one of the blade types).

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Conditions

The condition(s) this trial relates to.

acute respiratory failure Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory failure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    18 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Baylor Scott & White Research Institute

    Dallas, Texas, 75201, United States

  • Denver Health Medical Center

    Denver, Colorado, 80204, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Hennepin Healthcare component - Hennepin County Medical Center

    Minneapolis, Minnesota, 55415, United States

  • Lahey Clinic, Inc

    Burlington, Massachusetts, 01805, United States

  • Lsu/Umcno

    New Orleans, Louisiana, 70112, United States

  • Ochsner Clinic Foundation

    Jefferson, Louisiana, 70121, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Our Lady of the Lake Hospital, Inc.

    Baton Rouge, Louisiana, 70808, United States

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • Sentara Norfolk General

    Norfolk, Virginia, 23507, United States

  • Stanford University

    Stanford, California, 94305, United States

  • The Ohio State University

    Columbus, Ohio, 43210, United States

  • University of California, Los Angeles

    Los Angeles, California, 90095, United States

  • University of Colorado, Denver Anschutz Medical Campus

    Denver, Colorado, 80045, United States

  • University of Maryland Baltimore

    Baltimore, Maryland, 21201, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27109, United States

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Other studies related to the condition(s) this trial covers.