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BREATHE trial: does tube size affect recovery after emergency breathing support?

NCT ID NCT06939361

First seen Nov 01, 2025 · Last updated Jun 12, 2026 · Updated 32 times

Summary

This study looks at whether using a smaller or larger breathing tube during emergency intubation helps critically ill adults breathe better 6 months later. About 3,180 patients in emergency rooms or ICUs will be randomly assigned to get a smaller or larger tube. The main goal is to see if tube size affects shortness of breath, voice, and swallowing after recovery.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Atrium Health Wake Forest Baptist

    Winston-Salem, North Carolina, 27157, United States

  • Denver Health Medical Center

    Denver, Colorado, 80204, United States

  • Hennepin County Medical Center

    Minneapolis, Minnesota, 55415, United States

  • University of Alabama Hospital

    Birmingham, Alabama, 35233, United States

  • University of Colorado-Denver

    Denver, Colorado, 80045, United States

  • University of Washington Medical Center

    Seattle, Washington, 98104, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

Conditions

The condition(s) this trial relates to.

acute respiratory failure Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.