ACUTE LEUKEMIA

This study tests whether a new way of giving three drugs (ATG, tacrolimus, and methotrexate) can prevent a serious side effect called graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. The trial will enroll 29 adults aged 18-60 who have a matched don…

This early-stage study tests a new drug called ziftomenib combined with standard treatments for people with a type of acute myeloid leukemia (AML) that has come back or not responded to therapy. The main goal is to check safety and find the best dose. About 171 adults with specif…

This study looks at how well umbilical cord blood stem cells from unrelated donors help patients with serious blood cancers, immune problems, or genetic disorders. About 30 people will receive a transplant to see how quickly their blood cells recover and how often the transplant …

This study tests whether removing a specific type of immune cell (naive T cells) from donated stem cells can prevent chronic graft-versus-host disease (GVHD) in children and young adults with blood cancers. GVHD occurs when donor cells attack the patient's body, causing long-term…

This study tests a new drug, bleximenib, for people with acute leukemia that has come back or not responded to other treatments. The drug targets specific genetic changes in leukemia cells. The study has two phases: first to find the best dose and check safety, then to see how we…

This study compares two strategies to lower the risk of graft-versus-host disease (GVHD) in people with acute leukemia or myelodysplastic syndrome (MDS) who are getting a donor stem cell transplant. Participants will receive either a treatment that removes certain immune cells fr…

This study tests whether menin inhibitors can help prevent leukemia from returning after a stem cell transplant. About 20 adults with certain genetic types of acute leukemia will take these drugs as part of their regular care. Researchers will track how many patients stay cancer-…

This study tests a new radioactive drug called [177Lu]Lu-PentixaTher for people with acute leukemia that has come back or not responded to other treatments. The drug targets a protein (CXCR4) on leukemia cells to deliver radiation directly to the cancer. The trial will include up…

This study tests a new way to prepare donor stem cells for transplant in people with blood cancers like leukemia. By removing certain immune cells from the donated cells, researchers hope to lower the risk of graft-versus-host disease, a serious side effect. The study involves 70…

This study tests a drug called luspatercept in 46 people with acute leukemia who have anemia after a stem cell transplant. The goal is to see if it safely raises hemoglobin levels and reduces the need for blood transfusions. Participants get two shots of the drug in the first mon…

This program provides access to an experimental drug called AVM0703 for people with various solid tumors or blood cancers who have not responded to other treatments. It is available in the US upon a doctor's request. So far, 37 patients have received the drug, and side effects ha…

This study is for children under 25 who have had a stem cell transplant for blood cancers like leukemia. After transplant, their immune system is weak, putting them at high risk for dangerous infections. Researchers are adding back a specific type of donor cell (CD45RA-depleted) …

This early-phase study is testing whether bone marrow from deceased donors can be safely used for transplants in people with blood cancers like leukemia and lymphoma. About 12 patients will receive either strong or milder chemotherapy before the transplant. Researchers will monit…

This study tests a new experimental drug, LP-118, combined with three other medicines (ponatinib, vincristine, and dexamethasone) in adults with T-cell acute lymphoblastic leukemia or lymphoma that has come back or not responded to treatment. The goal is to find a safe dose and s…

This study tests whether combining two drugs, revumenib and mezigdomide, is safe for people whose acute leukemia has returned or not responded to prior treatment. It includes adults and teens aged 12+ with specific genetic subtypes (KMT2A-r, NUP98-r, or NPM1-m). The first part fi…

This study tests whether a lower dose of total body irradiation (200 cGy) before a bone marrow transplant works as well as the standard higher dose (400 cGy) for people with acute leukemia. The goal is to see if the lower dose reduces serious side effects like graft-versus-host d…

This study tests whether adding a precise form of radiation (IM-TMI) to the usual chemotherapy before a stem cell transplant can kill more cancer cells in the bone marrow and lower the chance of the disease coming back. It involves 27 adults aged 18-75 with acute leukemia or myel…

This study tests a stem cell transplant from a half-matched donor for people with blood cancers. Before the transplant, patients receive chemotherapy and low-dose radiation to prepare the body. The goal is to see if this approach helps the new stem cells grow and fight cancer wit…

This early-phase trial tests a new oral drug called BY002 in 18 adults with acute leukemia that has come back or not responded to standard treatments. The drug targets specific genetic changes (KMT2A rearrangements or NPM1 mutations) that drive the cancer. The main goals are to c…

This study tests a stem cell transplant using a milder chemotherapy combination (treosulfan and fludarabine) followed by donor stem cells and drugs to prevent graft-versus-host disease. It includes 132 people aged 2-75 with blood cancers like AML or MDS. The goal is to see if thi…

This early-phase study tests the safety and best dose of revumenib, a drug that blocks a protein fueling leukemia growth, in 27 adults and children with specific genetic types of acute leukemia. Participants take revumenib after a stem cell transplant to help keep the cancer from…

This study tests a two-step method of giving an anti-rejection drug (ATG) along with standard medications to prevent severe graft-versus-host disease (GVHD) in people with blood cancers receiving a stem cell transplant. About 56 adults aged 18-75 will participate. The goal is to …

This study is testing a new platform that uses advanced genetic and functional tests to better understand tumors from 300 people with various high-risk cancers, including leukemia, myeloma, and pancreatic cancer. The goal is to see if this detailed analysis can change the recomme…

This study looks at whether a formal care support program can help lower anxiety in people who have just been told they have acute leukemia. Researchers will compare anxiety levels between those who receive the support program and those who do not. The study involves 110 adults a…

This study tests a program called EASE that offers psychological support and early palliative care to people newly diagnosed with acute leukemia. Half of the 266 participants will get this extra support along with usual care, while the other half gets usual care alone. The goal i…

This study tests whether using virtual reality (interactive or hypnotic) during needle placement into an implantable port can reduce pain and anxiety in children aged 6 to 16 with acute leukemia. Over 3 months, 120 participants will be randomly assigned to virtual reality or stan…

This study looks at women who had a stem cell transplant for acute leukemia as adults. It aims to find out how often they experience gynecological problems like early menopause, vaginal graft-versus-host disease, or cervical issues. By reviewing medical records of 80 women, resea…

This study is collecting blood, bone marrow, and tissue samples from over 1,000 people with blood cancers like leukemia and myeloma. Researchers will use advanced lab techniques to find unique markers (biomarkers) in each person's cancer. The goal is to better understand these di…

This study is testing a web-based tool called TRIAL that provides information and resources about acute leukemia and clinical trials. Researchers want to see if the tool is easy to use and if people will complete the follow-up surveys. The study involves 75 adults with suspected …

This study tracks over 1,300 people with blood cancers like acute leukemia to see how many receive a stem cell transplant and why some do not. Researchers want to understand the medical and personal reasons behind these decisions. The goal is to identify barriers so more patients…

This research study aims to discover new genes that may increase the risk of childhood cancer. Researchers will collect blood samples and health information from 1,500 people in families where cancer clusters. The goal is to build a registry and sample bank to help future diagnos…

This study looks at blood cancer cells from 250 patients to understand which drugs might work best. Researchers will test many approved and experimental drugs on these cells in the lab. The goal is to find new treatment targets and match them to each patient's cancer type. This i…