ACUTE LEUKEMIA

This study tests a stem cell transplant using donors who are not a perfect match for patients with blood cancers like leukemia and lymphoma. Doctors give special drugs after the transplant to lower the risk of graft-versus-host disease, a common complication. The goal is to see i…

This early-phase study tests a new way to do stem cell transplants for people with advanced blood cancers like leukemia. Instead of using strong drugs to prevent complications, doctors add special immune cells (regulatory T-cells) to the transplant to help the body accept the new…

This study tests a new treatment called Orca-T for people with advanced blood cancers like leukemia. Orca-T is a special stem cell transplant designed to reduce serious side effects like graft-versus-host disease. The trial compares Orca-T to standard stem cell transplants in 187…

This study tested a bone marrow transplant using frozen, banked bone marrow from unrelated donors for people with blood cancers like leukemia. The goal was to see if it safely restores healthy blood cells and controls the disease. The trial was withdrawn before enrolling any part…

This study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections in the first 100 days while still preventing graft-versus-host disease. About 313 adults with various blood cancers…

This study tests a more precise radiation method (IMRT) for total body irradiation before stem cell transplant in 20 adults with acute leukemia or myelodysplastic syndrome. The goal is to reduce radiation to the lungs, lowering the risk of lung side effects while still preparing …

This study looks at whether training parents in specific skills can improve learning and school functioning for Latino children with acute leukemia or lymphoma. About 214 families will take part, with some parents receiving a high-intensity program and others getting standard sup…

This study looks at blood or bone marrow samples from 50 children and young adults (ages 1 month to 30 years) with newly diagnosed or relapsed acute leukemia. Researchers will use advanced genetic testing to find specific gene changes linked to cancer stem cells. The goal is to b…

This study tests whether a high-intensity digital health program—including video coaching and a special website—can help children aged 6 to 12 who were treated for leukemia or lymphoma improve their learning and school performance. Many children with these cancers are cured, but …

This study looks at whether a special, quick brain MRI (called magnetic resonance fingerprinting) can detect changes in the brains of children and young adults (ages 0-30) with acute leukemia who are receiving chemotherapy. Participants will have brain scans and take a fun, game-…

This study aims to uncover the genetic causes of blood and bone marrow cancers by analyzing samples from 5,000 participants. Researchers will look for specific cell abnormalities that drive cancer growth and test whether existing drugs can reverse them. The goal is to develop gen…