Vascular insufficiency disorder

This trial asks whether adding ozone gel to ultrasound treatment helps chronic venous leg ulcers heal better than either treatment alone. Venous leg ulcers are open sores that occur when leg veins fail to return blood to the heart, and they can be slow to heal. Researchers will c…

This trial tests whether a personalized tissue-engineered vein, made in the lab with a functioning valve, can safely replace a damaged vein segment in people with severe chronic venous insufficiency. Each participant undergoes surgery to swap a non-working valve in their femoral …

This early-stage trial is testing whether a single topical application of FGF-1, a protein that helps cells grow, is safe for people with diabetic or venous stasis ulcers. The study enrolls a small group of adults with full-thickness leg ulcers that have lasted at least 8 weeks. …

This early study tested a device called the Edwards PASCAL system, which is threaded through a blood vessel to repair the tricuspid valve in the heart. The valve can leak, causing symptoms like shortness of breath and swelling. The study included 65 people with severe leakage who…

This study tested a new way to treat venous leg ulcers, which are slow-healing wounds on the lower leg. Researchers used ultrasound to push hyaluronic acid gel into the wound and compared it to standard care in 64 patients. The goal was to see if this combination speeds up healin…

This study tested whether a new way of processing tissue for Edwards heart valves is safe and works well. 777 adults who needed a new aortic or mitral valve took part. Researchers checked for valve problems like wear or calcification over about a year, and will follow patients fo…

This study tested two new heart valves (Portico and Navitor) in 30 Indian patients with severe aortic stenosis, a condition where the heart's main valve narrows. The goal was to see if the valves are safe and work well. Researchers tracked complications and heart function for up …

This study tested a special wound dressing called MicroMatrix Flex on 25 adults with deep or tunneled wounds, such as pressure injuries, diabetic ulcers, or infected wounds. The goal was to see how safely and quickly the dressing helped close these wounds over 12 weeks. Researche…

This study tested a new tool called TELLTALE designed to safely cut a heart tissue flap during a valve replacement procedure (TAVR). In some cases, this flap can block blood flow to the heart, which is often fatal. The trial involved 90 adults at high risk of this complication. R…

This phase 2b trial tested a one-time application of a cell therapy made from donor skin cells (Allo-APZ2-CVU) in 159 people with chronic venous leg ulcers that hadn't healed despite standard care. The goal was to see if it could shrink or close these wounds better than a placebo…

This study tested a new heart valve, the SAPIEN 3, in 58 Chinese patients with severe aortic stenosis who were at high risk for traditional open-heart surgery. The valve was implanted using a thin tube through a blood vessel, avoiding the need for open surgery. The main goal was …

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This study tested a device called Insight Pro to see if it can safely detect lymphatic and vein disorders, such as lymphedema and chronic venous insufficiency. The device measures fluid buildup and skin hardness in the arms or legs. A total of 67 adults with or without these cond…

This trial tests whether a short 5-day course of the blood thinners rivaroxaban (Xarelto) or apixaban (Eliquis) can prevent blood clots that sometimes form after laser treatment for varicose veins. Adults with symptomatic vein reflux undergoing laser ablation of the great sapheno…

This trial tests whether a structured nursing program—including education before the procedure, support during it, and follow-up calls—can improve symptoms and quality of life for people with chronic venous disease undergoing foam sclerotherapy. Participants are randomly assigned…

This study tested a new, standardized process for providing assistive devices (like special tools) to help people put on and take off compression stockings. 220 adults who need these stockings long-term took part. The goal was to see if the new method improves how often people us…

This study looked at two surgical approaches for varicose veins: removing the main faulty vein and the visible varicose veins all at once, or removing just the main vein first and the varicose veins later. Researchers wanted to see which approach leads to better symptom relief an…

This study tested a dietary supplement containing diosmin, hesperidin, bromelain, and ruscus aculeatus in 80 adults with early signs of chronic venous disease, like heavy or swollen legs. Participants took the supplement for 12 weeks, and researchers measured changes in quality o…

This study tested two ways of applying compression bandages for venous leg ulcers: one that covers the heel and one that leaves it uncovered. Researchers measured the pressure under the bandage and checked ankle swelling in 102 patients. The goal was to see if leaving the heel ou…

This study tested a wearable compression device called Dayspring for people with lymphedema in one leg. 24 adults used the device daily for 3 months. Researchers measured changes in leg swelling and quality of life to see if the device was safe and helpful.

This study tested whether a combination of herbal ingredients (horse chestnut, polygonum acre, smilax pepyracea, and rutin) works as well as a standard drug (diosmin and hesperidin) for easing leg symptoms from chronic venous insufficiency. 120 adults with mild to moderate vein d…

This study tested a new portable, non-pneumatic compression device (Dayspring) against a standard pneumatic compression device for treating leg lymphedema. 121 adults with leg swelling used each device for three months, with a month off in between. Researchers measured changes in…

This study tested whether sleeping with a special leg-elevation device (UZit®) can ease symptoms of chronic venous disease, a condition where leg veins have trouble moving blood back to the heart. Seventeen adults used the device every night for one week. Researchers measured cha…

This study tested whether a virtual reality (VR) experience could reduce anxiety in 75 patients scheduled for a heart valve repair procedure called TEER. Patients either got standard education or standard education plus a VR tour of the procedure and hospital. The researchers mea…

This study looked at whether having a nurse talk with patients before and after a heart valve procedure could improve care. About 194 people took part. The nurses helped prepare patients and checked on them afterward, either by phone or in person. The goal was to see if this extr…

This study tested a treatment called Complex Decongestive Therapy (CDT) for people with venous insufficiency, a condition where leg veins struggle to send blood back to the heart. Twenty-one adults received either CDT plus exercises or exercises alone. The goal was to see if CDT …

This study looked at whether a special interactive dressing (UrgoStart Plus) used with compression bandages can help heal venous leg ulcers faster than standard dressings. Sixty adults with chronic leg ulcers were treated for up to 12 weeks. The goal was to see if the new dressin…

This study tests whether releasing a blood pressure cuff (used as a tourniquet) early during blood collection reduces the rate of hemolysis — when red blood cells burst and ruin the sample. About 792 emergency department patients with non-critical conditions will be randomly assi…

This study investigates whether people with chronic venous insufficiency—a condition where leg veins struggle to return blood to the heart—experience more swelling, pain, and weakness than healthy people. Researchers will measure breathing muscle strength, lung function, walking …

This study tested whether a special PET/CT scan can predict which patients with deep vein thrombosis (DVT) will later develop post-thrombotic syndrome (PTS), a condition causing chronic leg pain, swelling, and ulcers. Researchers imaged 51 patients shortly after their DVT and fol…

This study looks at whether a substance in the blood called suPAR can help predict serious health events in people with severe aortic stenosis or regurgitation. Researchers will measure suPAR levels and track participants for two years to see if higher levels are linked to death,…

This study watches and records pain levels at four key moments during radiofrequency ablation for varicose veins—from needle insertion to the end of the procedure. Researchers will look at how factors like age, gender, and body mass index relate to pain. The goal is to find patte…

This study looked at whether CT scans can help doctors choose the right size for the Perceval sutureless heart valve. The valve is used to replace a leaky aortic valve. Researchers studied 50 patients to see if CT-based sizing leads to good early results after surgery, like prope…

This completed study used artificial intelligence to analyze electrocardiograms (ECGs) and chest X-rays from over 116,000 adults. The goal was to see if combining these routine tests could predict which patients would develop moderate or severe heart valve regurgitation. The rese…

This study followed 82 people with blocked arteries supplying the back of the brain to see if low blood flow raises the risk of stroke or mini-stroke. Participants had already experienced a stroke or transient ischemic attack (TIA) and had at least 50% blockage in those arteries.…

This study tested how different levels of leg compression affect blood circulation in 30 adults after surgery. Participants received three pressure levels (low, moderate, high) on their calves, and blood flow was measured non-invasively. The goal is to gather early evidence for m…

This completed study looked at 26,000 patients who had outpatient procedures for blood vessel problems like peripheral artery disease, varicose veins, or dialysis access issues. The goal was to see how safe and effective these procedures are when done in an office-based angiosuit…

This study looked at 650 Brazilian patients with chronic venous disease (CVD), a condition that causes leg swelling, skin changes, and ulcers due to faulty veins. Researchers collected data on risk factors like obesity and smoking, other health problems, and treatments used. The …

This study tested a computer program called naevia medical that helps doctors decide the best treatment for heart valve disease. Researchers looked at 106 past patient cases to see if the tool gave better recommendations than usual care. The goal was to see if the tool could redu…

This study tested a new ultrasound device to measure skin stiffness (fibrosis) in people with lymphedema or venous insufficiency. Researchers compared results from 130 participants, including healthy volunteers, to see if the device could detect differences in skin hardness. The …

This study tested a new sensor (CIMON) to see if it can accurately measure how well compression bandages reduce leg swelling in people with chronic edema (long-term fluid buildup). Fifty-two adults with leg swelling who needed compression bandages took part. The sensor was placed…

This study looked at whether measuring the inferior vena cava through the liver (transhepatic approach) can predict if a patient needs more fluids after heart surgery. 40 ICU patients were included. The goal was to avoid giving too much fluid, which can be harmful. The study comp…

This study looked at how compression stockings of different strengths change the size and pressure of leg veins in people with chronic venous insufficiency and healthy volunteers. Researchers measured vein diameter and leg pressure while participants stood, sat, or lay down. The …