Social phobia

This trial tests whether Caplyta, a drug already used for other conditions, can reduce symptoms of social anxiety disorder in adults. Researchers will give 40 adults either Caplyta or a placebo every day for 8 weeks, with weekly clinic visits to track changes. The main question i…

This study examines whether therapist-guided internet-based cognitive behavioral therapy (ICBT) works well and saves money when used in routine healthcare for moderate depression, social anxiety disorder, and panic disorder. About 800 adults with these conditions will receive up …

This study compares two care models for treating anxiety in 556 children and teens aged 8-17. In stepped care, everyone starts with internet therapy and gets in-person help only if needed. In stratified care, participants are assigned to internet or in-person therapy based on the…

This study is testing whether a computer-delivered cognitive behavioral therapy (CBT) program can help people who have both an anxiety disorder and alcohol use disorder. The program teaches skills like breathing control and problem solving to break the cycle of negative feelings …

This study is testing a digital app called QbMobile that measures attention, impulsivity, and activity levels through two 10-minute tests. Researchers want to see if the app can help distinguish ADHD from conditions like bipolar disorder, autism, depression, and anxiety. About 30…

This study tests whether buspirone, a medication used for anxiety, is safe and effective for autistic youth aged 7 to 17 who also have anxiety disorders. Researchers will measure changes in anxiety symptoms over 16 weeks. The goal is to see if this drug can ease anxiety in this s…

Researchers are testing a computer-based program that aims to change how anxious children interpret ambiguous situations as threatening. The trial enrolls 72 youth ages 10 to 17 with generalized, separation, or social anxiety disorder. Participants are randomly assigned to either…

This study tests a computer-based therapy for adults with social anxiety disorder. Researchers want to see if it reduces anxiety and improves quality of life. About 80 people aged 18 to 60 with social anxiety will participate. The therapy is designed to be a new, accessible treat…

This study explores whether personalizing therapy for anxiety—by matching people to cognitive, behavioral, or mindfulness-based approaches—can improve outcomes. Researchers will look for baseline predictors of success and compare brief video-based skill training to four sessions …

This trial tests whether a device that sends mild electrical pulses to the ear — a method called transcutaneous auricular vagus nerve stimulation (taVNS) — can reduce symptoms of social anxiety disorder. About 100 adults with the condition will receive either real taVNS or a sham…

This study tests whether adding a computer task called gaze-contingent music reward therapy (GCMRT) to standard cognitive behavioral therapy (CBT) helps reduce anxiety in children aged 8 to 17. In GCMRT, children look at faces on a screen while pleasant music plays or stops depen…

This study tests whether a single dose of the drug Epidiolex (cannabidiol, or CBD) can reduce feelings of anxiety, physical stress signs, and brain activity linked to anxiety in people with social anxiety disorder. About 50 adults aged 18-55 with significant social anxiety will t…

This study tests whether a new form of exposure therapy, called Expectancy Focused Exposure (EFE), can reduce anxiety symptoms and prevent fear from returning more effectively than traditional exposure therapy. Adults with anxiety disorders—such as social anxiety, panic disorder,…

This study tests whether giving cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 kids will be randomly assigned to one of three delivery methods. The goal is to find out which approach impro…

This trial tests whether an 8-week mindful self-compassion training can reduce symptoms of anxiety and depression in adults diagnosed with generalized anxiety disorder, social anxiety disorder, panic disorder, or major depressive disorder. Participants are randomly assigned to th…

This trial tests whether sertraline, a widely used antidepressant, can reduce anxiety in children and teens aged 8 to 17 with neurodevelopmental disorders such as autism, ADHD, Fragile X syndrome, and Tourette syndrome. Participants receive either sertraline or a placebo for seve…

This Phase 2 trial tests whether a new drug called NTX-1472 can safely reduce symptoms of social anxiety disorder. About 100 adults will take either the drug or a placebo daily for 8 weeks. Researchers will measure changes in anxiety and avoidance using a standard scale, and trac…

This study looks at whether a computer-based attention training program can help adults with social anxiety disorder. Participants will complete eight sessions over four weeks, either doing the active training or a placebo version. The goal is to see if the training reduces anxie…

This study tests whether a text message program that helps people reduce 'safety behaviors' (like checking mirrors or seeking reassurance) can lessen appearance anxiety, body dysmorphic symptoms, and related eating or social anxiety issues. About 300 adults with high appearance c…

This study is testing a self-guided internet program called Velibra for people with panic disorder, social anxiety, or generalized anxiety disorder who are on a waitlist for treatment. The program uses cognitive behavioral therapy techniques over six weeks. Researchers want to se…

This study tests a self-guided online program called Radical Acceptance for adults with social anxiety disorder. About 100 participants will be randomly assigned to either the Radical Acceptance program or a relaxation skills program. Over two weeks, they will complete short home…

This study tests two types of social therapy for young adults (ages 18-30) with eating disorders or anxiety. One group gets educational sessions about brain function and social processing; the other adds interactive art tasks done in teams. Researchers will track changes in eatin…

This study compares a blended group therapy (online and in-person sessions) to standard in-person group therapy for adults with anxiety or depression. About 144 participants will receive 16 weeks of treatment. The goal is to see if the blended approach works as well and is accept…

This study tests whether an 8-week mindful self-compassion program can reduce symptoms of anxiety and depression. It compares attending the program in person versus through videoconference. The study involves 80 adults diagnosed with anxiety disorders or major depression who also…

This study looks at whether doing a positive mood treatment before standard exposure therapy can improve outcomes for people with social anxiety and public speaking fears. About 94 adults with social anxiety disorder will first receive either a positive mood treatment or a relaxa…

This study tests whether a newer type of talk therapy called transdiagnostic metacognitive therapy (tMCT) works better than standard cognitive-behavioral therapy (CBT) for people with generalized anxiety, social anxiety, or PTSD. About 86 adults in Sweden will receive either tMCT…

This study is testing whether a non-invasive brain stimulation method called intermittent theta-burst stimulation (iTBS) can reduce symptoms of social anxiety disorder. One hundred adults with social anxiety will receive either real iTBS (to the left or right prefrontal cortex) o…

This study tests a type of talk therapy called Acceptance and Commitment Therapy (ACT) for teenagers who have both social anxiety disorder and oppositional defiant disorder. The therapy aims to help teens become more flexible in their thinking and behavior. Researchers will measu…

This study is testing whether virtual reality (VR) exposure therapy can help people with social anxiety. Participants will use an Apple Vision Pro headset to practice social situations, with different levels of interaction. The goal is to understand how VR therapy works and wheth…

This study tests a stepped care model for treating anxiety in children and teens aged 7-17. It starts with a low-cost, parent-focused therapy and offers more intensive treatment only if needed. The goal is to make effective care more accessible while reducing costs and therapist …

This study is developing and testing a new internet-delivered cognitive behavioral therapy (ICBT) program for children and teens aged 8-17 with anxiety disorders. The 12-week program, guided by a therapist, uses exposure therapy to help young people face their fears. Researchers …

This study tests a Chinese-language online therapy for social anxiety disorder in Hong Kong adults. About 110 participants will receive either therapist-guided treatment, coach-guided self-help, or be placed on a waitlist. The goal is to see if the cheaper coach-led option works …

This study compares a single therapy (Transdiagnostic Behavior Therapy) to separate treatments for social anxiety and PTSD in 264 veterans. The goal is to see if one therapy can effectively reduce symptoms and improve daily life. Participants will be assessed before, during, and …

This study tests whether a nasal spray called fasedienol can quickly reduce anxiety in people with social anxiety disorder when they have to speak in public. Sixty adults will receive either the spray, a combination, or a placebo before a speech challenge. The goal is to see if i…

This study is testing two different ways of delivering intensive cognitive behavioral therapy (CBT) to veterans with PTSD and anxiety disorders. One format is individual therapy over two weeks, and the other is group therapy over two days. Both are compared to standard care. The …

This study tests whether adding a guided imagery exercise after a virtual reality (VR) public speaking session helps people feel less anxious in new speaking situations. 48 adults with high public speaking fear will do one VR speech, then either mentally rehearse it or use imager…

This study tests whether adding a positive mental rehearsal after exposure therapy helps people with social anxiety feel better faster. Forty participants with high social anxiety will complete a one-session exposure exercise, then either standard or positive mental rehearsal. Re…

This study tests a new online treatment for social anxiety that combines talk therapy with special breathing exercises. Researchers will enroll 96 adults with social anxiety and randomly assign them to either the combined therapy or a control group. The goal is to see if adding b…

This study looks at whether combining two common therapy techniques—changing negative thoughts and practicing detached mindfulness—works better than using them alone for people with anxiety or depression. Researchers will compare the effects of each technique and their order. The…

This study tests whether a parent-only therapy (SPACE) can reduce anxiety in teens, compared to a parent education support group. About 108 adolescents with anxiety disorders will participate. Parents attend 12 weekly sessions, and researchers measure teen anxiety symptoms before…

This study tests a digital program called UKADO for people waiting for face-to-face therapy for depression or anxiety. About 312 adults will try different versions of the program—some focused on problems, others on strengths—with or without human support. The goal is to see which…

This study compares two treatments for social anxiety in adolescents and young adults: virtual reality exposure therapy and the medication sertraline. Fifty-six participants will be randomly assigned to either VR sessions that simulate anxiety-provoking social situations or daily…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study interviews 30 adults with generalized anxiety, social anxiety, or PTSD who previously completed a trial comparing two therapies: metacognitive therapy (MCT) and cognitive-behavioral therapy (CBT). The goal is to learn what participants thought about each treatment to h…

This study explores whether showing youth with social anxiety disorder very brief, almost invisible images of judgmental faces can help rewire their brain's fear response. Eighty participants aged 16-22 will undergo brain scans while viewing these micro-exposures, and rate their …

This study looks at whether brain scans can help predict which adults with social anxiety disorder will benefit from group cognitive behavioral therapy (CBT). Researchers will scan the brains of 190 adults with social anxiety before and after 12 weeks of therapy. Their results wi…

This study is testing whether a carbon dioxide (CO2) challenge can predict which patients with anxiety, OCD, PTSD, or panic disorder will not respond to exposure-based therapy. Researchers will enroll 600 adults and measure their reaction to breathing CO2-enriched air before star…

This study tests whether real-time brain scans (fMRI) can help young adults with anxiety learn to regulate their emotions better. Participants will practice reappraising negative thoughts while seeing their own brain activity. The goal is to understand which brain areas are invol…

This study tests an experimental drug to see if it can fix brain patterns linked to avoiding rewards in people with major depression or anxiety. About 112 unmedicated adults will have brain scans and do decision-making tasks. The goal is to understand how the drug works, not to c…

This study looks at whether a single dose of cannabidiol (CBD) can help college students with social anxiety let go of fearful memories more quickly. Researchers will condition participants to fear certain faces using mild wrist shocks, then give either CBD or a placebo to see wh…

This study is testing a new family-based program (Fam-AID) for teens aged 13-21 who are getting treatment for substance use and also have anxiety or depression. The program adds extra support for mental health and family involvement to their usual care. Researchers want to see if…

This study looks at how exercise affects brain markers linked to anxiety. Thirty adults with anxiety disorders will follow a 4-week virtual exercise program. Researchers will measure specific brain chemicals from blood samples to understand the biological changes behind exercise'…

This study tests whether a device called rTMS, which uses magnetic pulses to temporarily change brain activity, can alter how people with anxiety respond to fearful situations. Researchers will measure brain signals and reactions in 80 adults who recently started anxiety treatmen…

This study uses transcranial magnetic stimulation (TMS) to explore how the brain controls social motivation in adults who avoid social situations due to depression or social anxiety. Forty participants will undergo MRI scans, computer tasks, and personalized TMS over four visits.…

This study aims to understand why some people with social anxiety or body dysmorphic disorder respond fully to cognitive behavioral therapy while others do not. Researchers will use brain scans, thinking tests, and questionnaires to look for early signs of non-response. The study…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study tests whether a technology called transcranial focused ultrasound (tFUS) can temporarily change brain activity linked to anxiety. Researchers will recruit 40 adults with anxiety disorders who recently started treatment. Participants will undergo brain imaging and then …

This study is testing whether brain scans can predict how well people respond to internet-based cognitive behavioral therapy (iCBT) for depression, insomnia, and social anxiety. Researchers will scan the brains of 150 participants before they start 12 weeks of online therapy. The…

This study tests whether a digital website called Careverse can help caregivers of people with serious illnesses engage more in advance care planning. About 200 caregivers will be randomly assigned to use the website or receive usual care. Researchers will measure how involved ca…

This study compares two types of exposure therapy for agoraphobia: real-life exposure and virtual reality exposure. Researchers will measure how these therapies affect body awareness and stress-related chemicals. The goal is to understand why therapy works and how to improve it f…