Sleep-wake disorder

This study explores whether combining traditional Chinese medicine acupoint massage with a tailored exercise program can help older adults with sarcopenia (muscle loss) and sleep disturbances. Researchers will also examine how sleep patterns and body constitution relate to these …

This study looks at whether using a CPAP machine for sleep apnea after a heart procedure (catheter ablation) can help prevent atrial fibrillation from coming back. About 658 adults with both conditions will be randomly assigned to use CPAP for a year or receive usual care. The go…

This study tests whether a special therapy program with a mobile app helps pregnant people stay on their buprenorphine medication for opioid use disorder, compared to just logging their doses. About 37 pregnant women will be randomly assigned to either the app-based therapy or da…

This phase II trial is testing whether mirtazapine, an antidepressant, can improve mood, sleep, and motor symptoms in people with Rett syndrome. The study will enroll 54 females aged 5 to 40 with a confirmed MECP2 mutation. Participants will receive increasing doses of mirtazapin…

This study is testing whether simple wearable devices can accurately screen for sleep disorders in children with cerebral palsy. About 140 children aged 6 to 15 will wear the devices at home and then undergo a standard hospital sleep test. The goal is to see if the wearable metho…

This study looks at whether a home sleep apnea test is as accurate as the standard overnight sleep lab test for children ages 5 to 12. Researchers will compare results from both tests and see how they affect treatment choices. The goal is to find a more comfortable and convenient…

This study is testing whether a portable sleep monitor can accurately detect obstructive sleep apnea in children with autism spectrum disorder. Twenty children aged 6 to 18 will wear the portable device at the same time as their standard in-hospital sleep test. Researchers will c…

This study tests whether taking branched chain amino acids (BCAAs) twice a day for three weeks can improve sleep in people with traumatic brain injury. Researchers will also check if the supplement is easy to take and if participants stick with it. The study involves 300 veterans…

This study tests an experimental drug called cleminorexton in 222 adults with narcolepsy type 1 or 2. The drug mimics a natural brain protein that helps keep people awake. The goal is to see if it safely reduces daytime sleepiness and improves daily functioning. Participants must…

This study tests a new tablet called ALKS 2680 to see if it can reduce daytime sleepiness in adults with narcolepsy type 2. About 176 participants will receive either the study drug or a placebo for 12 weeks. The main goal is to measure how well they can stay awake using a standa…

This phase 3 trial tests whether a daily tablet called ALKS 2680 can reduce daytime sleepiness and cataplexy (sudden muscle weakness) in 150 adults with narcolepsy type 1. Participants will take the drug or a placebo for 12 weeks, and researchers will measure changes in sleep tes…

This phase 3 trial tests whether a daily tablet called ALKS 2680 can reduce severe daytime sleepiness and sudden muscle weakness (cataplexy) in adults with narcolepsy type 1. About 150 participants will receive either the drug or a placebo for 12 weeks. The study measures improve…

This study tests whether adding melatonin to cognitive behavioural therapy for insomnia (CBT-I) improves sleep in adults aged 60 and older with chronic insomnia. Participants are randomly assigned to receive CBT-I plus melatonin, CBT-I plus a placebo, or sleep education plus a pl…

This study tests a special nasal airway device (ssNPA) in 40 children with weak throat muscles and obstructive sleep apnea, including those with Down syndrome. The device is designed to keep the airway open during sleep without needing surgery. Researchers will measure how well i…

This study is testing the long-term safety and how well ALKS 2680 works over time in people with narcolepsy type 1, type 2, or idiopathic hypersomnia. Participants take a once-daily tablet at different doses. The goal is to see if the drug remains safe and effective for staying a…

This pilot trial compares two traditional Chinese herbal formulas — Chaihushugan Decoction and Wen Dan Tang — for treating chronic insomnia. Adults with chronic insomnia will take one of the two herbal granules three times daily for eight weeks. Unlike many herbal studies, this o…

This study tests whether a special 40 Hz flickering light, used for 30 minutes each night for a week, can improve insomnia in people with Parkinson's disease. Thirty participants will be randomly assigned to receive either the 40 Hz light or a control light. The main goal is to s…

This study tests whether a short program of aerobic exercise, combined with parent-led sleep training, can improve sleep and behavior in children with autism who have sleep problems. About 120 children aged 3-11 will take part. The exercise sessions are twice a week for 30 minute…

This trial investigates whether diaphragmatic breathing exercises can improve sleep quality in women with polycystic ovarian syndrome (PCOS). Fifty-four women aged 25-35 with PCOS and poor sleep will practice breathing exercises three times a week for eight weeks. The study measu…

This pilot study is testing a device that sends a mild electrical current to the brain (tACS) to see if it can reduce anxiety and improve sleep in people with generalized anxiety disorder and chronic insomnia. Thirty adults will receive 20 sessions over four weeks. The goal is to…

This study tests a new drug called ALKS 2680 to see if it can safely reduce daytime sleepiness in people with idiopathic hypersomnia, a condition causing excessive sleepiness without clear cause. About 126 participants will receive either the drug or a placebo daily for 8 weeks. …

This study tests whether adding foot reflexology to standard physical therapy can reduce pain and improve sleep in women with fibromyalgia. Sixty women aged 18–65 will receive either standard therapy alone or standard therapy plus foot reflexology twice a week for six weeks. Rese…

This study tests whether a structured exercise program can improve heart rate variability (a measure of heart health), reduce menopausal symptoms, and enhance sleep and quality of life in postmenopausal women aged 45 to 65. Forty women will either join a supervised 12-week exerci…

This study looks at how to best offer cognitive behavioral therapy for chronic insomnia to older veterans at 20 VA clinics. About 20 veterans will take part to see if the therapy helps them sleep better and feel better. The goal is to find the best way to bring this effective tre…

This study tests whether natural supplements like lavender oil, PEA, and OEA can help adults with moderate stress and sleep problems. About 240 participants will take a daily capsule for 8 weeks, comparing the supplements to a placebo. The goal is to see if these natural options …

This study tests whether a daily probiotic supplement called Limosilactobacillus reuteri LM1063 can improve sleep in healthy adults who have poor sleep quality. Over 8 weeks, 80 participants will take either the probiotic or a placebo, and researchers will measure sleep using bot…

This study looks at whether doing yoga during pregnancy can lower stress, improve sleep, and enhance sexual quality of life. Researchers will compare 35 pregnant women who practice yoga with 35 who do not. All participants are in their third trimester and must be able to read Tur…

This study tests whether older adults (ages 65-74) can improve their balance, reduce fear of falling, and sleep better by doing combined physical and mental exercises at home via video calls with a physiotherapist. Participants will perform 4 weeks of dual-task exercises—like wal…

This study is testing whether a special drink called Avnace eZZe can help people with insomnia sleep better. 75 adults with sleep and anxiety issues will drink it each night for 28 days. Researchers will track sleep quality using questionnaires and a sleep monitor to see if it wo…

This study tests whether a smartphone app called SleepUp can help people with insomnia. The app provides cognitive-behavioral therapy (CBTi) and extra features like meditation and relaxation sounds. Researchers will compare the app to standard therapy with a psychologist and to b…

This study looks at whether teaching teens with overweight or obesity how to sleep better can help them lose more weight when combined with standard diet and exercise advice. About 126 teens aged 13 to 17 who have poor sleep will join. Half will get usual care, and the other half…

This study tests whether a special memory support program can help people aged 50 and older remember and stick to their sleep treatment. The program uses simple memory strategies alongside standard sleep therapy. Researchers will track sleep quality, daily functioning, and life s…

This study tests a small, non-invasive device that stimulates a nerve in the leg to see if it can safely ease Restless Legs Syndrome (RLS) during pregnancy. Fifteen pregnant women between 21 and 26 weeks will use the device for 30-minute sessions over 8 weeks. Researchers will ch…

This study looks at 600 adults with chronic insomnia to see if those who sleep less than 6 hours respond differently to treatment than those who sleep longer. Participants first receive 8 weeks of cognitive behavioral therapy (CBT-I). If that doesn't help, they are randomly assig…

This study compares myofascial release (a type of massage) and cupping therapy to see which better improves quality of life in people with restless leg syndrome and knee osteoarthritis. 54 adults aged 40-70 with moderate to severe knee arthritis will receive 12 sessions over 4 we…

This pilot study tests whether screening and treating sleep disorders during tobacco or cannabis cessation therapy helps people stay abstinent longer. 80 participants will either get usual care or extra sleep-focused care. The study follows them for 6 months to see if addressing …

This study looks at sleep problems in healthy Somali Americans and how they might raise the risk of high blood pressure. Researchers will use sleep studies and 24-hour blood pressure monitors on 240 adults. The goal is to find hidden sleep issues and understand their link to bloo…

This study explores how light influences the body beyond vision—affecting sleep, mood, and thinking—in people with sleep disorders, neurological conditions, psychiatric conditions, or eye diseases. Researchers will measure the pupil's response to specific light exposures to under…

Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) causes sudden, severe behavioral and cognitive changes in children, but doctors currently rely only on symptoms for diagnosis. This study aims to identify biological markers—such as genetic, metabolic, and sleep-related signa…

This study investigates whether people with sleep disorders before noncardiac surgery take longer to wake up from anesthesia and have a lower quality recovery. Researchers will monitor brain activity during and after surgery in 80 adults, comparing those with poor sleep to those …

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Twenty participants who already have a DBS implant will spend two nights in a sleep lab—one night with the device on and one night with it off. Researchers will measure sleep qu…

This study follows 50 children and adults with Baker Gordon Syndrome, a rare genetic disorder, to track how the condition changes over time. Participants will undergo brain scans, EEGs, and genetic testing, and complete developmental assessments. The goal is to create better tool…

This study looks at whether being awake during the late-night hours (2:00-4:00 AM) can worsen mood, increase hopelessness, and impair decision-making in people who have had suicidal thoughts in the past six months. Researchers will monitor 90 adults in a lab and at home under dif…

This study looks at how sleep problems and stress can trigger migraines in adults. Participants wear a WHOOP band to track sleep and body signals, and answer daily questions via a smartphone app. The goal is to find personal patterns and give tailored advice to reduce migraine at…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study looks at how Cognitive Behavioral Therapy for Insomnia (CBT-I) affects the body's stress system, including the hormone cortisol. Researchers will track 115 adults with chronic insomnia, measuring sleep and stress markers before, during, and after therapy. The goal is t…

This study is translating a sleep screening questionnaire into Turkish and testing how well it works for children with complex chronic conditions. Researchers will enroll 330 children and teens, tracking their sleep at home and during stays in the pediatric intensive care unit. T…

This study looks at how sleeping at high altitude (2,877 meters) affects the sleep quality of 32 employees at Pic du Midi. Researchers will compare nights spent at home versus nights spent at the summit using sleep recordings. The goal is to understand sleep changes in people who…

This observational study surveys 150 people with isolated REM sleep behavior disorder (iRBD) and their caregivers. iRBD causes people to act out dreams during sleep and is linked to future brain diseases. The study asks about their emotional well-being, access to information, and…

This study is testing whether artificial intelligence can predict hospital readmissions in surgical patients by analyzing data from smartwatches and smart rings. About 300 adults undergoing elective surgery will wear these devices before and after their operation, tracking heart …

This study looks at how sleep issues contribute to tiredness and thinking problems in people with multiple sclerosis (MS). About 382 MS patients and a control group without MS will have overnight sleep tests, thinking assessments, and questionnaires. The goal is to better underst…

This study aims to see if a short, easy questionnaire can help detect sleep disorders in people visiting a heart doctor. Researchers will ask 1500 adults about their sleep and check if certain sleep problems are linked to heart disease. The goal is to make it simpler for doctors …

This study tests a program called REPOSE, where a patient navigator helps families overcome barriers to getting specialist care for children with sleep-disordered breathing. The navigator provides support, resources, and coordinates care between doctors and parents. The goal is t…

This study looks at whether sleep disorders make vertigo worse for people with Ménière's disease, a condition that causes hearing loss, ringing in the ears, and dizziness. Researchers will track 100 adults to see if those with more severe vertigo also have more sleep problems. Th…

This study follows 800 adults who spent at least 48 hours in the ICU to understand why some develop chronic pain. Researchers will call participants at 90 and 180 days after discharge to ask about pain, sleep, and quality of life. A smaller group will also have a detailed physica…

This study looks at why people with damage to the hypothalamus or pituitary gland often have sleep problems. Researchers will compare 60 patients to healthy volunteers using sleep tests, hormone measurements, and brain scans. The goal is to find better ways to prevent and treat t…

This study follows 65 adults with obstructive sleep apnea to see how three weeks of CPAP therapy changes their thinking skills, blood markers of brain health, and emotional well-being. Participants complete memory and attention tests, give blood samples, and fill out questionnair…