Schizophrenia 1

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This study tests a new group program called Forging New Paths for adults with serious mental illness who have also been involved with the criminal justice system. The program combines cognitive behavioral therapy with social learning techniques to reduce aggression and help peopl…

This trial compares a generic form of cariprazine (a drug used for schizophrenia) to the brand-name version Reagila®. Healthy adults aged 18 to 55 receive a single dose of either the generic or brand drug under fasting conditions. The main goal is to see if the generic version is…

This study tested whether a probiotic supplement (Pediococcus acidilactici) could reduce metabolic problems like high cholesterol and blood sugar caused by antipsychotic drugs. 36 adults with first-episode psychosis or schizophrenia took the probiotic or a placebo alongside their…

This study tested whether mindfulness training can prevent relapse in people with psychosis. 152 participants who were in remission were randomly assigned to either mindfulness training or standard education. Researchers tracked them for 12 months to see who had a relapse.

This study tests whether a 6-week online self-help program can help people with psychotic disorders who hear voices at least once a week. The program combines metacognitive training and mindfulness techniques to reduce the frequency and distress of auditory hallucinations. Partic…

This study tests whether immersive virtual reality (VR) can safely help people with schizophrenia improve their thinking skills, reduce symptoms, and function better in daily life. Forty adults with schizophrenia or schizoaffective disorder will either receive VR-based cognitive …

This study tested a brief, two-session therapy program for young adults (ages 18-35) who had recently started early psychosis services. The program, adapted from a US-based intervention called 'Just Do You,' aimed to improve treatment engagement and recovery by addressing barrier…

This study tested whether a non-invasive brain stimulation technique called tDCS can reduce auditory hallucinations in people with psychotic disorders. Twenty-four participants received the stimulation while researchers measured changes in hallucination severity and brain activit…

This study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…

This study tested a new medication called HS-10380 in 363 Chinese adults hospitalized with acute schizophrenia. The goal was to see if it reduces symptoms like hallucinations and delusions better than a placebo or an existing drug. Participants took the drug for 6 weeks, and doct…

This study tested whether a group reminiscence program—where people share and discuss past memories—is practical and helpful for adults hospitalized with schizophrenia. Thirty-eight participants took part in an 8-week program. Researchers measured changes in thinking, communicati…

This study looked at whether a 6-week mindfulness-based yoga program could improve psychological well-being and happiness in adults with schizophrenia. 91 participants from community mental health centers were randomly assigned to either the yoga program or their usual care. The …

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This study tested whether a gentle electrical current applied to the scalp (tDCS) can reduce symptoms of major depression, schizophrenia, OCD, generalized anxiety, and insomnia. 320 adults aged 16–65 received multiple sessions over weeks. Researchers measured symptom changes usin…

This study tested whether forest therapy—mindful walking, sun bathing, hugging trees, and meditation—could improve symptoms and reduce inflammation in 80 adults with psychotic disorders. Half received forest therapy plus standard care for 8 weekly sessions; the other half receive…

This pilot study tested a new virtual reality (VR) therapy called ENGAGE for people with schizophrenia who have negative symptoms like lack of motivation and pleasure. Thirty participants either received 10 sessions of VR therapy or standard care. The study aimed to see if the VR…

This pilot study tested a mobile app called iCanChange in 100 young adults (ages 18-35) with psychosis and cannabis use disorder. The app uses motivational interviewing and cognitive behavioral therapy techniques through short interactive modules. The main goal was to see if the …

This study tested two mobile health (mHealth) strategies to help people with schizophrenia manage their symptoms. 299 participants used smartphone tools to track and improve issues like depression, anxiety, and insomnia. The goal was to see if these digital tools could make a rea…

This study tested whether a 4-week virtual reality (VR) training program could improve thinking skills in 62 people with depression, bipolar disorder, or psychotic disorders like schizophrenia. Participants practiced daily-life tasks in VR, such as cooking and shopping, guided by…

This study tested two different 2-month training programs to help veterans with psychosis improve their social interactions and quality of life. 113 veterans took part. The goal was to see which training worked better for everyday social situations.

This completed study tested whether a mild electrical current applied to a specific brain region (the right superior temporal sulcus) could reduce hallucinations in 12 adults with psychosis. Participants received transcranial electrical stimulation while researchers measured chan…

This pilot study tested whether a nurse-led community-based rehabilitation program is feasible and acceptable for people with psychosis in Blantyre, Malawi. Sixty adults with psychosis were randomly assigned to either usual care or the home-based program. The study focused on rec…

This study asks whether a scenario-based simulation, where nursing students interact with an actor portraying a person with schizophrenia, can boost their knowledge, empathy, and caregiving skills. Around 105 students will complete questionnaires before and after the simulation, …

This completed study tested whether targeted brain stimulation (TMS) could affect attention and nicotine cravings in 15 people with schizophrenia or schizoaffective disorder who smoke. Researchers applied different types of TMS to a brain network linked to attention and measured …

This study tested a new way to improve mental health services for people with psychosis in Uganda. Instead of just doctors making decisions, people who have experienced psychosis were trained to help at home, in the community, and at clinics. The goal was to see if this approach …

This study tested a smartphone app called A4i designed to help people with schizophrenia manage their illness and stay connected with their care providers. 91 adults with schizophrenia or related disorders used the app for 6 months. The goal was to see if the app was practical an…

This study tested whether sending text message reminders and support to young people with psychosis after an emergency room visit helps them attend their first early psychosis appointment. 186 participants were enrolled. The goal was to see if a low-cost, youth-friendly approach …

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study tested a system where police officers can call a mental health provider during encounters with people who have serious mental illness. The goal was to see if this reduces arrests and helps people stay connected to care. Over 1,400 participants were randomly assigned to…

This study looked at whether using very low nicotine cigarettes along with nicotine-containing e-cigarettes can reduce harmful chemical exposure in smokers with mental health conditions. 88 participants were assigned to different combinations of cigarettes and e-cigarettes. The m…