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VR therapy shows promise for Schizophrenia's 'Negative' symptoms

NCT ID NCT06993831

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested a new virtual reality (VR) therapy called ENGAGE for people with schizophrenia who have negative symptoms like lack of motivation and pleasure. Thirty participants either received 10 sessions of VR therapy or standard care. The study aimed to see if the VR therapy is feasible and acceptable, and if it might help reduce negative symptoms and improve daily life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Virtual Reality-based psychotherapy
What this could lead to
If it works, this could offer a new way to ease negative symptoms like lack of motivation and pleasure in people with schizophrenia.
What could go wrong
This is a small pilot study with only 30 participants, so results may not apply to everyone. It focuses on feasibility, not yet on proving effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Dec 2024

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ICD-10 diagnosis of a schizophrenia-spectrum disorder (F2x) * Negative symptom score of ≥3 on the SANS items avolition or anhedonia Exclusion Criteria: * Diagnosis of organic brain disease * Intellectual disability (IQ \< 70) * Current diagnosis of drug dependency * Command of spoken Danish or English inadequate for engaging in therapy * Refusing to be informed on incidental findings on the MRI scans

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Conditions

The condition(s) this trial relates to.

Psychotic Disorders schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Copenhagen Research Center for Mental Health (CORE), Mental Health Services CPH, Denmark

    Hellerup, Greater Copenhagen, 2900, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.