VR therapy shows promise for Schizophrenia's 'Negative' symptoms
NCT ID NCT06993831
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested a new virtual reality (VR) therapy called ENGAGE for people with schizophrenia who have negative symptoms like lack of motivation and pleasure. Thirty participants either received 10 sessions of VR therapy or standard care. The study aimed to see if the VR therapy is feasible and acceptable, and if it might help reduce negative symptoms and improve daily life.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Virtual Reality-based psychotherapy
- What this could lead to
- If it works, this could offer a new way to ease negative symptoms like lack of motivation and pleasure in people with schizophrenia.
- What could go wrong
- This is a small pilot study with only 30 participants, so results may not apply to everyone. It focuses on feasibility, not yet on proving effectiveness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Started
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Dec 2024
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ICD-10 diagnosis of a schizophrenia-spectrum disorder (F2x) * Negative symptom score of ≥3 on the SANS items avolition or anhedonia Exclusion Criteria: * Diagnosis of organic brain disease * Intellectual disability (IQ \< 70) * Current diagnosis of drug dependency * Command of spoken Danish or English inadequate for engaging in therapy * Refusing to be informed on incidental findings on the MRI scans
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Copenhagen Research Center for Mental Health (CORE), Mental Health Services CPH, Denmark
Hellerup, Greater Copenhagen, 2900, Denmark
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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