Prostate carcinoma

This early-phase trial tested a shorter course of radiation for men whose prostate cancer came back after their prostate was removed. Instead of the usual 6-7 weeks of daily radiation, researchers gave higher doses over just 2-4 weeks, focusing the strongest radiation on the tumo…

This study tests a new long-acting injection called Debio 4228 for men with advanced prostate cancer. The goal is to lower testosterone levels to control the cancer. About 55 men will receive different doses to find the best one. This is not a cure, but a way to manage the diseas…

This trial tests whether a dye called indocyanine green, viewed with near-infrared imaging, can help surgeons spot pelvic lymph nodes during robot-assisted prostate removal in men with stage II prostate cancer. The dye is injected into the prostate, and the imaging system is used…

This early-phase study tests a new, ultra-short course of radiation therapy for men with intermediate-risk prostate cancer. The treatment uses MRI guidance to precisely target the prostate and the main tumor inside it. The goal is to see if this approach is safe and practical, wi…

This phase 2 trial is testing whether surgery and radiation can help men whose prostate cancer has come back and spread to a few spots in the body. About 20 participants will receive either surgery to remove the spread tumors or targeted radiation, or both. The main goal is to se…

This trial compares two types of hormone injections given before prostate brachytherapy (internal radiation) for early-stage prostate cancer. One injection lasts one month, the other three months, and both are used to lower testosterone to make radiation more effective. The study…

This study tests a type of radiation called high-dose brachytherapy for men with prostate cancer that hasn't spread. Doctors place tiny radioactive sources directly into the prostate to deliver a strong dose to the tumor while sparing nearby healthy tissue. The goal is to control…

This study tests two drugs, saruparib and darolutamide, given alone or together before prostate removal surgery in men with newly diagnosed prostate cancer. The goal is to see how these drugs affect cancer cells and check for side effects. About 120 men with localized, higher-ris…

This study tested whether adding an experimental drug (MK-2206) to the standard hormone therapy bicalutamide can better control prostate cancer in men whose PSA levels are rising after initial treatment. About 108 men with recurrent prostate cancer took part. The goal was to see …

This study tests whether the drug olaparib can help control aggressive variant prostate cancer when given after initial chemotherapy. About 96 men will receive cabazitaxel, carboplatin, and prednisone first, then either olaparib or observation. The goal is to see if olaparib exte…

This study tested a device called NanoKnife to treat prostate cancer in 121 men with intermediate-risk disease. The goal was to safely destroy cancer tissue while avoiding major side effects. Researchers checked if the treated area was cancer-free after 12 months and tracked any …

This study tests whether adding an immunotherapy drug called lorigerlimab to standard chemotherapy (docetaxel) can help men with a tough-to-treat type of prostate cancer live longer without their disease getting worse. About 150 men with metastatic castration-resistant prostate c…

This study tested a combination of three hormone-blocking drugs (enzalutamide, abiraterone, and standard hormone therapy) given before surgery in 12 men with newly diagnosed prostate cancer that hasn't spread. Researchers also used special PET/CT scans with a new tracer to see if…

This early-stage trial tested the safety and best dose of adding niclosamide (a drug used for tapeworm infections) to standard hormone therapy (enzalutamide) in 6 men with advanced prostate cancer that no longer responds to hormone treatment. The goal was to see if the combinatio…

This early-phase trial tested a new drug called AZD8186 combined with the chemotherapy docetaxel in 23 patients with advanced solid tumors that have PTEN or PIK3CB gene mutations. The main goal was to find the safest dose and understand side effects. The study is complete, but re…

This study tested a precise radiation implant (brachytherapy) for men with low-risk prostate cancer. Instead of treating the whole prostate, doctors placed radioactive seeds only in the tumor area. The goal was to see if this targeted approach could deliver the right radiation do…

This study compared two types of radiation therapy for men with intermediate-risk prostate cancer: standard image-guided external beam radiation (IGRT) versus IGRT plus a high-dose-rate brachytherapy boost. The goal was to see which treatment works better and what side effects oc…

This study tested a drug combination (abiraterone acetate plus prednisolone and hormone therapy) given before radiation in 45 men with high-risk localized prostate cancer. The goal was to see if the treatment could shrink tumors and lower PSA levels. The approach aims to improve …

This study tested a new way to treat intermediate-risk prostate cancer using a 3D map to guide microwaves directly to the main tumor. 76 men across Europe received the treatment, and researchers checked if the cancer was gone after 12 months. The goal is to destroy the cancer whi…

This large phase 3 trial studied 1,538 men with intermediate-risk prostate cancer. It compared dose-escalated radiation therapy alone versus radiation plus short-term (6 months) androgen deprivation therapy (hormone therapy). The goal was to see if adding hormone therapy improves…

This study looked at 588 men with intermediate-risk prostate cancer to see if adding external beam radiation to brachytherapy (placing radioactive seeds in the prostate) works better than brachytherapy alone. The goal was to see which approach better controls the cancer over time…

This study tested a shorter course of proton radiation (5 treatments over 2 weeks) for men with localized prostate cancer, compared to the usual 8 weeks. The goal was to see if this approach maintains quality of life and controls the cancer. 150 men with low- to intermediate-risk…

This study tested a treatment called focused ultrasound (HIFU) that aims to destroy only the cancerous part of the prostate, avoiding common side effects like incontinence and impotence from standard treatments. It involved 174 men aged 50-80 with intermediate-risk prostate cance…

This early study tested a combination of heat therapy (hyperthermia) and high-dose radiation for men whose prostate cancer returned after earlier radiation. Only 3 men took part, and the main goal was to check safety and side effects. The approach aims to make cancer cells more s…

This study tested a drug called enzalutamide in 1401 men with a type of prostate cancer that has not spread to other parts of the body but is no longer controlled by standard hormone therapy. The goal was to see if enzalutamide could delay the cancer from spreading. Participants …

This study tested whether a device called the Pelvic Clock® helps men recover bladder control and sexual function faster after robotic prostate cancer surgery. Sixty men aged 55 to 80 used either the device plus standard exercises or standard exercises alone. The main goal was to…

This study tested a new way to treat early-stage prostate cancer using MRI-guided ultrasound waves to destroy tumors without surgery. 25 men with low-to-intermediate risk prostate cancer received the treatment. The main goal was to see if no significant cancer remained one year l…

This pilot study tested whether a diet and exercise program could prevent or reduce metabolic side effects like insulin resistance and weight gain in 20 men with prostate cancer receiving hormone therapy and radiation. Participants followed dietary instructions and did aerobic an…

This study tested a new way to treat low-risk prostate cancer using MRI-guided laser ablation. Seven men with early-stage prostate cancer received the treatment to see if it was safe and could successfully destroy tumors. The goal was to target only the cancer while avoiding side…

This early-phase trial tested whether injecting a man's own bone marrow stem cells into the penis could help restore erections after prostate cancer surgery. The study included 18 men who had normal erections before surgery but developed erectile dysfunction due to blood vessel d…

This phase 2 trial tested whether adding a radioactive drug (I-131-1095) to standard enzalutamide therapy helps men with a specific type of advanced prostate cancer that had worsened on another treatment. The study enrolled 120 men with PSMA-positive metastatic castration-resista…

This study tested a single injection of triptorelin pamoate that lasts 6 months in 195 Chinese men with advanced or metastatic prostate cancer. The goal was to lower testosterone to castrate levels, which helps slow cancer growth. Results showed the injection effectively reduced …

This large registry study is testing whether a special type of PET scan, called PSMA-PET, can better detect where prostate cancer has returned after initial treatment. Thousands of men with suspected recurrent prostate cancer across Ontario will receive this scan. The goal is to …

This completed registry study at Princess Margaret Cancer Centre tested whether a special PET scan tracer called 18F-DCFPyL (PSMA) can find prostate cancer that has spread to lymph nodes or other organs better than standard CT and bone scans. A total of 142 men with intermediate-…

This study looks at whether cooling the mouth with popsicles during chemotherapy can reduce taste changes in prostate cancer patients. About 60 people starting a type of chemo called taxane will be asked to suck on popsicles during their infusion. The goal is to see if this simpl…

This study tested whether a very low dose of apalutamide, taken for 3-4 weeks before prostate removal surgery, could lower PSA levels in 34 men with early-stage prostate cancer. The goal was to see if the drug blocks testosterone's effect on cancer growth. If it works, it might o…

This study looked at 200 men with early-stage prostate cancer who had robotic surgery to remove the prostate. It compared two surgical methods—the standard approach and a newer 'HOOD' technique—to see which one helps men regain bladder control sooner after surgery. The goal is to…

This study tested whether an online program combining nutrition counseling and resistance training could improve physical function in older adults (65+) who finished treatment for breast, colorectal, or prostate cancer. 75 participants received virtual sessions with dietitians an…

This pilot study tested whether vitamin B6 supplements can reduce hot flashes in 43 men with prostate cancer who were receiving hormone therapy (ADT). Hot flashes are a common side effect of this treatment. The study measured how bothersome hot flashes were before and after 8 and…

This study tested a 10-week stress management group program for Spanish-speaking Hispanic men who had treatment for prostate cancer. The program taught relaxation, coping skills, and ways to handle stress. Researchers measured changes in quality of life, mood, and physical sympto…

This completed study tested whether wearing an InBody Band 3 fitness tracker for 6 weeks could help Black prostate cancer survivors become more active and improve their quality of life. Thirteen participants wore the tracker and had regular check-in discussions. The main goals we…

This study looks at how Spanish-speaking Latiné men cope after prostate cancer treatment, especially with issues like erectile dysfunction and urinary problems. Researchers will survey and interview 55 survivors to understand their needs and cultural barriers. The goal is to crea…

This study explores whether a virtual robot assistant can help Black men recently diagnosed with prostate cancer get the support and information they need. Researchers will ask about 50 participants to use the app and give feedback on how easy and helpful it is. The goal is to se…

This study looks at genes in men with advanced prostate cancer that has spread and is no longer responding to hormone therapy. Researchers will analyze tissue, blood, and urine samples from 92 patients receiving a drug called abiraterone. The goal is to find genetic changes that …

This study looks at whether a web-based virtual genetics board helps doctors discuss and manage prostate cancer genetics. About 118 healthcare providers, including oncologists and genetic counselors, will use the board and then give feedback through surveys and interviews. The go…

This study looked at 14 men with intermediate-risk prostate cancer who were scheduled for prostate removal surgery. Each man received two different types of PET scans to see which one better highlights cancer cells. The goal was to compare the scans' ability to detect and measure…

This early-phase trial tested a precise, high-dose radiation technique called stereotactic body radiotherapy (SBRT) in 42 patients with breast, lung, or prostate cancer that had spread to several places in the body. The main goal was to find the safest dose and check for side eff…

This study looked at how two prostate cancer drugs, darolutamide and enzalutamide, affect thinking and memory in men with advanced prostate cancer. About 111 men took one of the two drugs and completed computer-based cognitive tests over time. The goal was to see if one drug caus…

This early-phase trial tested a fluorescent antibody that attaches to prostate cancer cells. Seven men with moderate- to high-risk prostate cancer received the antibody before robotic prostate removal surgery. The goal was to see if the glowing antibody could help surgeons identi…

This early-phase trial studied how compounds from black raspberries are absorbed and processed in 60 men with prostate cancer who were scheduled for surgery. Participants ate a black raspberry confection and followed a special diet before surgery. The goal was not to treat cancer…

This study aimed to improve how doctors predict whether prostate cancer has spread to nearby lymph nodes. Researchers combined patient information, MRI scans, and genetic data from 367 men who had their prostate removed. The goal was to create a more accurate tool to help decide …

This study looked at whether cancer survivors living in rural areas can create their own survivorship care plans and learn from telehealth education. 261 survivors of breast, colorectal, lung, lymphoma, or prostate cancer took part. The goal was to see if this approach improves t…

This completed study surveyed 51 men with localized prostate cancer and their healthcare providers in Belgium, Italy, and Spain. The goal was to understand how acceptable artificial intelligence (AI) is as a tool to help diagnose prostate cancer, and whether people are willing to…

This study tested whether breathing in humidified wood or fragrant oils could mimic the immune-boosting effects of a forest walk. 28 adults who finished chemotherapy or radiation for early-stage breast or prostate cancer took part. The goal was to see if this approach is practica…

This study looked at whether a blood test measuring how certain immune cells die after radiation can predict long-term side effects in breast and prostate cancer patients. Researchers enrolled 885 participants and tracked late complications. The goal is to personalize treatment t…

This completed study tracked 1000 men with localized prostate cancer who had their prostate removed. Researchers measured a heart protein called troponin before and after surgery to see if the operation caused hidden heart injury. The goal was to learn how often heart problems ha…

This study measured how often muscle loss (sarcopenia) happens in men aged 70 and older with prostate cancer who are treated with radiation and hormone therapy. Researchers screened 112 patients using a simple questionnaire and body scans. The goal was to understand risk factors …

This study tested whether a peer-led health education program could help African American men better understand genetic testing for prostate cancer. 149 men with or without a personal or family history of prostate cancer took part. The program aimed to reduce confusion and improv…

This study reviewed medical records from over 1,300 men with metastatic prostate cancer that still responds to hormone therapy. Researchers wanted to see how long patients actually take the pills apalutamide or enzalutamide when prescribed by their own doctors in routine care. Th…

This study tested whether using at-home monitoring devices (like a wristband pedometer, scale, and blood pressure cuff) can help improve care for cancer patients after they leave the hospital following surgery. 22 patients with various cancers participated. The goal was to see if…

This early trial tested a less invasive treatment for prostate cancer called microwave ablation, which uses heat to kill tumor cells. One man with prostate cancer received the ablation before his scheduled prostate removal surgery. The goal was to see if the procedure is safe and…

This small study looked at whether special MRI scans can help doctors adjust radiation treatment for high-risk prostate cancer. Only 5 men took part, all with aggressive cancer. The goal was to see if the MRI method was reliable enough to guide changes in radiation doses. Because…