Polyp

This phase 3 trial tests whether the experimental drug felcorekibart, added to standard care, can reduce nasal polyps and improve symptoms like nasal blockage and loss of smell in adults with chronic rhinosinusitis with nasal polyps. Participants receive either felcorekibart or a…

This phase 3 trial tests whether an experimental drug called felcorekibart can reduce nasal polyps and improve symptoms like nasal blockage and loss of smell in adults with chronic rhinosinusitis with nasal polyps. Participants receive either felcorekibart or a placebo on top of …

This study tests whether adding a heat treatment (thermal ablation) to the standard procedure for removing large colon polyps can lower the chance they grow back. About 752 adults will be randomly assigned to receive either standard removal alone or standard removal plus burning …

This trial compares two endoscopic techniques for removing flat, non-cancerous colorectal polyps that are 10-20 mm in size. One method uses a cold snare (no heat), while the other uses a hot snare with electrocautery. The goal is to see if the cold approach is just as effective a…

This trial tests whether a cold knife hysteroscopy technique (Yiwu procedure) can remove multiple endometrial polyps as effectively as standard electrocision, but with less damage to the uterine lining. About 850 women aged 20 to 48 with multiple polyps will be randomly assigned …

This trial compares two techniques—snare tip soft coagulation and hybrid APC—used to burn the edges of the wound after removing large colon polyps. The goal is to see which method is faster while still preventing polyps from coming back. About 140 adults with large non-cancerous …

This study will follow 220 patients with benign gallbladder diseases who cannot have surgery. It compares two non-surgical approaches: endoscopic drainage with possible stone removal versus traditional drainage alone. The goal is to see which method leads to fewer complications a…

This study looks at whether taking the drug stapokibart for 4 weeks before sinus surgery helps adults with chronic nasal polyps more than surgery alone. About 48 participants will receive either the drug or a placebo before their operation and be followed for nearly a year. The g…

This study tests whether an artificial intelligence (AI) system can help doctors spot more precancerous polyps and colorectal cancers during colonoscopy compared to standard procedures. Over 3,300 adults scheduled for screening or surveillance will be randomly assigned to AI-assi…

Colonoscopy helps doctors find and remove polyps that can turn into bowel cancer, but the right side of the bowel often stays dirty even after standard preparation, so polyps there can be missed. This trial tests whether giving a small sodium phosphate enema into the right colon …

This trial tests two new imaging modes, VIST and SFI, during colonoscopy to see if they help doctors find and classify colorectal polyps better than standard white light. About 990 adults undergoing screening or surveillance colonoscopy will be randomly assigned to one of the thr…

This study tests whether an artificial intelligence model can use routine laboratory results and patient information to identify people at high risk for colorectal adenomas, which are precancerous polyps. The researchers will collect data from 400 adults undergoing colonoscopy an…

This trial tests whether an AI system called GI Genius can help doctors accurately tell apart small colorectal polyps (5 mm or less) during a colonoscopy—identifying which ones are harmless versus those that need monitoring. For each small polyp, doctors first record their own di…

This study compares a new 3D colonoscopy with the standard 2D version to see which more accurately identifies polyps that could become colorectal cancer. About 600 adults undergoing colonoscopy will have their polyps examined with both methods, and the results will be checked aga…

This study tests whether spraying a mix of acetic acid and indigo carmine dye during colonoscopy helps doctors find more precancerous polyps (called sessile serrated lesions) in the right side of the colon compared to standard white-light colonoscopy. About 2,689 adults aged 45-8…

This study tests a new device that flattens colon polyps before they are examined under a microscope. The goal is to help doctors better identify sessile serrated lesions, a type of polyp that can lead to colorectal cancer. About 1,156 adults having polyps removed during a colono…

This study will test artificial intelligence algorithms that analyze video from routine endoscopies of the head and neck. The AI will try to detect, classify (benign vs. malignant), and outline lesions, comparing its performance to doctors and lab results. About 283 adults with s…

This study will check how well a non-invasive stool test (quantitative fecal immunochemical test, or qFIT) can detect colorectal cancer and precancerous lesions like adenomas and serrated polyps. Researchers will compare the test results with colonoscopy findings in 150 adults ag…

This study looks at whether people who have had large colon polyps removed can safely wait longer for their next colonoscopy. About 760 adults will be split into two groups: one getting the standard schedule (colonoscopy at 6, 18, and 48 months) and another getting a relaxed sche…

This study tests whether spraying a protective medication (sucralfate) on the wound after removing colon polyps can prevent delayed bleeding better than the standard method of placing clips. The trial will include 160 patients who take blood thinners and have large polyps. Partic…

This study looks at whether a gel called Hyalosem can prevent scar tissue from forming inside the uterus after surgery. Researchers will review the medical records of 80 women who had uterine surgery and then received the gel. The goal is to see if the gel reduces adhesions and i…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This trial is testing whether an experimental drug called anrikefon can improve recovery and reduce pain after laparoscopic gallbladder removal, compared to a standard painkiller. Adults undergoing this surgery will receive either anrikefon or the standard drug, and their pain le…

This study tests whether letting patients give themselves sedation medication (propofol) by pressing a button during a colonoscopy leads to higher satisfaction than standard sedation given by a doctor. About 40 adults scheduled for colonoscopy will be randomly assigned to either …

This study tests whether a special imaging mode called RDI helps doctors remove early-stage cancers from the stomach, esophagus, or colon more quickly and safely than standard white-light endoscopy. About 158 adults with early cancers or precancerous lesions will be randomly assi…

This early study tests a new device that supports the colon wall during polyp removal. It involves 4 people who have a positive stool test and a polyp on the left side of the colon. The main goal is to see if the device can be placed successfully in one try.

This study tests whether a non-invasive nerve stimulation device can improve the quality of bowel cleansing before a colonoscopy. About 270 adults scheduled for colonoscopy will receive either the real stimulation or a sham treatment. The goal is to see if this approach leads to …

This study tests whether adding magnesium sulfate or lidocaine to a standard sedative (dexmedetomidine) better prevents coughing after functional endoscopic sinus surgery. Coughing after this surgery can cause bleeding and slow recovery. About 102 adults will be randomly assigned…

This study looks at whether showing AI suggestions a few seconds later helps doctors make better decisions when diagnosing small colon polyps. Seventy endoscopists will watch 100 polyp videos, with some seeing AI advice right away and others seeing it after a delay. The goal is t…

This study follows about 1,000 adolescents and adults in China with severe chronic rhinosinusitis with nasal polyps, a condition causing nasal blockage, loss of smell, and poor quality of life. Over 36 months, researchers will track the treatments patients actually receive, such …

This study tests a new short camera called a rectoscope to check the lower bowel after rectal tumour removal. The goal is to see if it can be used in the clinic with a simple enema instead of strong bowel prep, making follow-up checks faster and reducing waiting lists. Thirty pat…

This study is a large registry that will collect detailed information from thousands of women undergoing surgery for non-cancerous gynecologic conditions like fibroids, endometriosis, and ovarian cysts. The goal is to track surgical techniques, complications, and recovery in real…

This study looks at 3,000 people who had surgery for colorectal cancer to see how often polyps come back in the colon afterward. Researchers will check if the type and stage of the original cancer are linked to polyp recurrence. The goal is to improve follow-up care by identifyin…

This study looks at people who have had certain types of colon polyps (serrated lesions) removed. It aims to find out why some of them later develop new advanced growths in the colon. By tracking 750 adults over time, researchers hope to identify risk factors that could help doct…

This study looks at how often polyps in the stomach or colon grow back after being removed during a scope procedure. Researchers will follow about 2,000 adults for up to three years to track recurrence and identify risk factors like polyp size, lifestyle, and health history. The …

This study looks at whether a special decision aid helps patients with a cancerous colon polyp choose between more surgery or careful monitoring. About 110 adults in Denmark will use the aid during their doctor visit. The goal is to see if it changes treatment choices and improve…

This study looks at chronic sinusitis with nasal polyps, a condition causing long-term nasal congestion and breathing problems. Researchers will measure inflammation markers and examine nasal tissue from 10 adults using a steroid spray (budesonide). The goal is to better understa…

This study looks at whether measuring the thickness (viscosity) of nasal mucus can help doctors better understand the type of inflammation in people with chronic sinusitis and nasal polyps. Researchers will compare mucus from 60 patients having sinus surgery—some with polyps and …

This study tests whether an artificial intelligence (AI) system can help doctors in general hospitals accurately decide how to manage small colon polyps (5mm or smaller) during a colonoscopy. About 363 adults with at least one small polyp will be randomly assigned to have their p…

This study tests whether a computer-aided detection system can help doctors find more polyps in the right side of the colon during a colonoscopy. About 686 adults aged 40-75 will have two colonoscopies in one session, with the AI system used in one of them. The goal is to see if …