Spray instead of clips: new hope for preventing Post-Polypectomy bleeding
NCT ID NCT07257926
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether spraying a protective medication (sucralfate) on the wound after removing colon polyps can prevent delayed bleeding better than the standard method of placing clips. The trial will include 160 patients who take blood thinners and have large polyps. Participants will be randomly assigned to receive either the sucralfate spray or clips, and will be monitored for bleeding for 28 days.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 160 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * patients who take antiplatelets or anticoagulants with large polyps (size ≥ 1 cm) Exclusion Criteria: * lacked complete data (serum creatinine, platelet count, and prothrombin time) pertaining to the previous 6 months * those who did not discontinue or inadequately discontinued antiplatelet agents or anticoagulants * those who had a known allergy to sucralfate
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Web tool aims to spot hidden cancer in large colon polyps without special equipment
- Powder spray may stop rebleeding after colonoscopy
- New blood test could spot colon cancer before it spreads
- Your DNA may push you to get that first colonoscopy
- Could a glass of special milk help prevent colon cancer?