Can a 'Cold Knife' beat heat for polyp removal?
NCT ID NCT07737301
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This trial tests whether a cold knife hysteroscopy technique (Yiwu procedure) can remove multiple endometrial polyps as effectively as standard electrocision, but with less damage to the uterine lining. About 850 women aged 20 to 48 with multiple polyps will be randomly assigned to one of the two surgeries. The main question is whether the cold knife approach leads to fewer polyps returning within a year, while keeping surgical risks low.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cold knife hysteroscopic polypectomy (Yiwu procedure)
- What this could lead to
- If successful, this technique could offer a safer, less damaging way to remove multiple endometrial polyps, potentially lowering the chance they grow back.
- What could go wrong
- This is an early comparison trial; the cold knife method may not prove as effective as standard electrocision, and could carry different surgical risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 850 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Aug 2026
An estimate. Start dates often move.
- Expected to finish
-
Jun 2029
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
20 to 48 years
- Sex
-
Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Aged 20 to 48 years. Regular menstrual cycles (22-35 days); no need for postoperative artificial cycle therapy. Patients requiring long-term medication such as those with PCOS are excluded. Voluntarily decline Mirena insertion, oral contraceptives or other progestogen therapy after surgery. Diagnosed with multiple endometrial polyps confirmed by at least one transvaginal ultrasound examination. Scheduled to undergo hysteroscopic treatment. Generally good health status apart from endometrial polyps. Normal cervical screening results, or results requiring no therapeutic intervention after assessment. No pregnancy plan within 1 year after hysteroscopic surgery. Able to provide written informed consent. Exclusion Criteria: Postmenopausal women. Irregular menstrual cycles requiring postoperative hormonal intervention (e.g., polycystic ovary syndrome, PCOS). Pregnant or breastfeeding women (interval between delivery, miscarriage or lactation and treatment initiation less than 3 months). History of endometrial ablation, pelvic radiation therapy, etc. Current use of tamoxifen or similar agents. Confirmed malignant genital tract tumor or breast cancer. Poor follow-up compliance and inability to complete 1-year follow-up. Other conditions deemed inappropriate for enrollment by investigators. Concurrent participation in another clinical drug trial. Inability to comply with the study protocol for any reason. Concurrent uterine malformation requiring synchronous surgery, moderate or severe intrauterine adhesions, embedded intrauterine device, submucous myoma greater than 1 cm, and other similar conditions. Combined severe internal diseases or surgical contraindications.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Yiwu cold knife technique for multiple endometrial polyps are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.