Osteonecrosis of genetic origin

This study tested the safety and effectiveness of eliglustat, an oral medication, in 57 children aged 2 to 17 with Gaucher disease types 1 and 3. Some children also received the standard enzyme therapy imiglucerase. Researchers measured how the drug moves through the body, side e…

This early-stage trial tested a new gene therapy called FLT201 in 10 adults with Gaucher disease type 1. The therapy uses a harmless virus to deliver a working copy of the gene that produces a missing enzyme. The main goal was to check safety and see if the treatment can boost en…

This study tested a triple therapy—surgery, stem cells, and hyperbaric oxygen—in 24 patients with early-stage osteonecrosis (bone death) of the hip. After two years, patients reported better hip function and fewer needed a hip replacement. The approach aims to stop the bone from …

This study followed 77 people who had a procedure called Subchondroplasty for hip bone defects. Doctors injected a calcium phosphate bone filler into the damaged area. The goal was to see if it improved pain, movement, and daily activities over two years. Results were measured us…

This study tested a new implant called Agili-C for people with knee cartilage damage or early arthritis. 251 participants received either the implant or standard surgery. The goal was to see if the implant improved pain and function over 5 years. Results suggest it may be a helpf…

This study compared two surgical methods to repair damaged knee cartilage: a newer cell-based technique (autologous chondrocyte implantation) and a standard bone-graft method (mosaicoplasty). 58 adults aged 18-50 with isolated knee lesions took part. The goal was to see which app…

This study tests whether a specific exercise technique called Proprioceptive Neuromuscular Facilitation (PNF) can improve pain, posture, and muscle strength in people with upper crossed syndrome—a condition marked by forward head and rounded shoulders. Half the participants will …

This study compares two types of Pilates—one done in water and one on a mat—to see which better improves breathing, mobility, and quality of life in older women with a curved upper spine (kyphosis). Forty women aged 55 to 65 with mild to moderate kyphosis will follow a 12-week pr…

This study tested whether a non-opioid pain regimen (celecoxib plus acetaminophen) works as well as an opioid regimen (oxycodone plus acetaminophen) for pain after ankle arthroscopy. 112 adults were randomly assigned to one of the two groups. The goal is to find a safer way to ma…

This study compared two types of exercises—thoracic extension and global postural corrective exercises—in 30 adults with hyper kyphosis (excessive rounding of the upper back). Researchers measured pain, range of motion, and posture to see which approach worked better. The goal wa…

This study compared two types of exercise—back extensor strengthening and core stability—in 40 adults aged 18-40 with mild to moderate thoracic kyphosis (a rounded upper back). Participants did exercises for 6 weeks, and researchers measured changes in pain, spinal movement, post…

This study tested a 12-week home exercise program for heart rehab patients with hyperkyphosis (excessive forward curve of the upper back). 62 participants were split into three groups: those doing the home exercises plus standard rehab, those doing only standard rehab, and those …

This study tested a 12-week holistic exercise program for 62 teenage boys with thoracic kyphosis (excessive rounding of the upper back). One group did corrective exercises plus postural awareness training, while another did only back-focused exercises. Both groups saw improvement…

This study tested a hands-on technique called diaphragmatic myofascial release in 44 adults with thoracic kyphosis (excessive rounding of the upper back). The goal was to see if releasing tension in the diaphragm muscle could improve chest expansion and heart rate. Participants r…

This early-stage study tested the safety and tolerability of a new drug called RAB001 in 16 healthy adults. Researchers gave single and multiple injections at two dose levels to see how the body handles the drug and if it causes side effects. This is a first step before testing t…

This study looked at bone tissue from 34 men who had hip replacement surgery due to femoral head necrosis (bone death in the hip joint). Researchers used advanced imaging and spectroscopy to identify changes in bone structure and composition. The goal was to better understand wha…

This study measured the stiffness, tone, and elasticity of back and chest muscles in 88 adults with and without hyperkyphosis (excessive rounding of the upper back). Researchers used a handheld device and a flexible ruler to compare muscle properties and spinal curvature. The goa…

This study measured levels of brain chemicals related to oxidative stress and inflammation in people with type 1 Gaucher disease and healthy volunteers. Researchers gave 33 participants with Gaucher disease the antioxidant N-acetylcysteine (NAC) for about 90 days to see if it cha…

This study looks at how the position of the shoulder blade relates to arm movement, strength, and performance in children aged 7 to 14 with a rounded upper back (thoracic hyperkyphosis). Researchers measured shoulder blade position, joint motion, muscle strength, and upper body f…

This study examined the connection between a rounded upper back (thoracic kyphosis) and shoulder pain, movement, strength, and daily function in 30 adults aged 18 to 60 with a kyphosis angle over 40 degrees. Researchers measured the curve of the spine, pain levels, shoulder motio…

This study reviewed existing research on poor posture (like forward head posture and rounded shoulders) in children aged 6 to 18. It looked at how growth and daily activities, such as using technology, affect posture. The goal was to identify gaps in knowledge and suggest ways to…

This completed study looked at 151 children with common postural conditions like flat feet, knock knees, or scoliosis. Researchers used wearable motion sensors and clinical tests to measure balance and motor control, then compared the results to healthy children. The goal was to …

This study tested whether a smartphone inclinometer app can reliably measure the forward curve of the upper spine (thoracic kyphosis) compared to a standard flexible ruler. Sixty adults with at least a 30-degree curve were measured by two different raters. The goal was to see if …