Neuralgia

This trial is testing whether taking a daily Ceylon cinnamon supplement, combined with a structured educational program, can improve blood sugar control, cholesterol levels, and nerve pain in adults with type 2 diabetes and painful diabetic peripheral neuropathy. About 900 partic…

This study tests a free, mobile-friendly digital tool designed to help healthcare providers quickly determine the right level of care for people with chronic pain. The tool uses five standard questionnaires to generate a recommendation—from primary care to specialist referral. Re…

This pilot study tests whether placing a soft tissue matrix over a nerve during forearm flap surgery can prevent chronic pain and numbness. Eighty head and neck cancer patients will be randomly assigned to receive either the matrix or standard closure. The main goal is to see if …

This trial tests whether applying a 5% lidocaine plaster daily for two months can prevent chronic nerve pain after an osteoporotic vertebral fracture. Participants aged 50 and older with a recent fracture and moderate pain are randomly assigned to receive the plaster plus standar…

This study tests whether a gentle electrical brain stimulation technique called tDCS, given alongside standard rehab, can prevent the development of chronic neuropathic pain after a stroke. Sixty adults who recently had a stroke will receive either real or sham tDCS for 10 sessio…

Researchers at the University of Miami are testing a non-invasive ear stimulation treatment to understand nerve pain in older adults living with HIV. The study enrolls 70 people with HIV-associated peripheral neuropathy, a condition that causes tingling, numbness, or pain in the …

This trial tests whether a lidocaine gel applied to the feet can ease painful diabetic neuropathy as well as the oral drug duloxetine. Adults with type 2 diabetes and moderate-to-severe nerve pain will be randomly assigned to one of the two treatments for 8 weeks. Researchers wil…

This trial tests whether a non-invasive brain stimulation technique called intermittent theta-burst stimulation (iTBS) can reduce lower-limb spasticity and neuropathic pain in people with multiple sclerosis. About 40 adults with MS and significant leg stiffness and pain will rece…

This study tests whether taking a daily capsule of decaffeinated green tea extract can reduce nerve pain in people who have had cancer treatment. The trial enrolls 20 adults with stable pain who are not currently undergoing cancer therapy. Participants receive either the green te…

This study tests a new program called Empowered Relief for Caregivers (ER-CY), a single two-hour online class for caregivers of children and teens with chronic pain. Up to 80 caregivers will take the class and complete surveys and interviews over three months. The goal is to see …

This study tests a device called Scrambler Therapy to relieve nerve pain in children with cancer that has spread to the bone. The treatment is non-invasive and aims to lower pain levels and reduce the need for pain medications. About 70 children who can describe their pain will t…

This study tests a device called BreEStim that uses electrical stimulation timed with your breathing to reduce nerve pain after spinal cord injury. About 66 adults with long-term spinal cord injury and stable pain will receive either active or sham treatment. The goal is to see i…

This trial tests whether a non-invasive brain stimulation technique called temporal interference stimulation (tTIS) can reduce neuropathic pain—pain caused by nerve damage. Researchers will monitor changes in pain levels and brain plasticity in 60 adults with peripheral neuropath…

This phase III trial tests whether a daily probiotic supplement, OXXYSLAB®, can reduce peripheral neuropathy—nerve damage causing pain and numbness—in people with stage III colon cancer receiving oxaliplatin-based chemotherapy (FOLFOX or XELOX). About 130 participants will take e…

This early study tests a brain stimulation device for people with long-term nerve pain that hasn't responded to other treatments. The device is surgically placed to send mild electrical pulses to specific brain areas. The main goal is to see if the procedure is feasible and accep…

This study tests two types of brain training—motor imagery (mentally picturing movements) and sensorimotor training (repetitive sensory exercises)—against standard therapy for people with multiple sclerosis who have neuropathic pain in their legs. The goal is to see which approac…

This trial investigates whether high-intensity peripheral magnetic stimulation can reduce pain and improve function in adults with traumatic peripheral nerve injury. Participants receive either active or sham magnetic stimulation alongside a standard exercise program. The study m…

This trial investigates whether the drug crisugabalin can reduce neuropathic pain in people with neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune condition affecting the nerves. Participants will receive either crisugabalin or a placebo, and their pain levels wil…

This study investigates whether giving lidocaine or dexmedetomidine through a vein during urethral reconstruction surgery can lower pain right after surgery and reduce the chance of chronic pain lasting months later. About 80 adults scheduled for this surgery will receive one of …

This study investigates whether a high-concentration capsaicin patch can reduce chronic neuropathic pain in the pelvic and perineal region. Researchers will measure changes in pain sensitivity before and after treatment in 30 adults with long-lasting pelvic nerve pain. The goal i…

This study tests whether a newer form of spinal cord stimulation (paresthesia-free SCS) actually reduces chronic pain or if its benefits are just a placebo effect. Ninety adults with severe neuropathic pain will receive both active and placebo stimulation for six weeks each, with…

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study tests if botulinum toxin (like Botox) provides longer-lasting pain relief than a standard numbing injection for people with chronic nerve pain after losing a limb in combat. About 100 adults with confirmed nerve pain will get one of the two injections and be tracked fo…

This study tests whether extracorporeal shockwave therapy (ESWT) can reduce pain and improve daily function in people with peripheral neuropathy who also have plantar fasciitis (heel pain). About 114 adults will receive either real or sham shockwave treatment. The goal is to see …

This pilot study tests whether a small device that gently stimulates a nerve in the ear can safely reduce nerve pain in people with spinal cord injury. 32 adults will use the device at home for 30 days. The main goal is to see if the treatment is practical and well-tolerated, whi…

This study tests whether a spinal cord stimulator can reduce chronic nerve pain caused by chemotherapy. 68 adults with pain lasting over a year will have the device implanted and then randomly receive either active or sham stimulation. The goal is to see if active stimulation pro…

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. Thirty adults with shingles-related pain will receive a single application of the gel. Researchers will measure pain levels before and after application, focusing on relief with…

Stanford University is testing a wearable ultrasound device that targets peripheral nerves to reduce chronic pain. The device is placed on the skin over the painful area and delivers focused ultrasound waves. In this early study, 90 adults with nerve-related pain will attend a si…

This study tests an injectable supplement that combines B vitamins with an energy molecule (ATP) to treat painful diabetic nerve damage. Two hundred adults with diabetes and nerve pain will receive either the ATP-enhanced shot or a standard B vitamin shot for 12 weeks. Researcher…

This study tests whether aromatherapy foot massage can reduce neuropathic pain in people with type 2 diabetes. 78 participants will massage their feet for 10 minutes, three times a week for 4 weeks. Researchers will compare the effects of an aromatherapy oil versus a plain oil to…

This study tests whether doctors can safely perform ultrasound-guided pain procedures, like nerve blocks, at home for patients with chronic or cancer pain. It includes 100 adults already receiving home hospital care. The goal is to see if this approach reduces pain, cuts down on …

This study tests a new approach to reduce nerve pain in people with spinal cord injury. Ten participants will receive ten sessions combining mild brain stimulation (tDCS) with virtual reality walking and muscle vibration. The goal is to see if this drug-free combo can lower pain …

This study tests whether a gentle, hands-on movement technique applied to the non-painful side can reduce pain and disability in people with cervical radiculopathy (nerve pain in the neck and arm). It includes 40 adults who will receive a single session of this technique. The goa…

This early study tests whether an extended-release form of glibenclamide (glyburide), a diabetes drug, can safely reduce nerve pain in people with multiple sclerosis. Ten adults with MS and moderate-to-severe nerve pain will receive either the drug or a placebo. The main goal is …

Researchers at the University of Minnesota are studying why chronic pain varies so much from person to person. The study enrolls 400 adults with chronic low back pain or spinal cord injury-related neuropathic pain. Participants answer brief surveys four times a day for at least t…

This study aims to classify the different types of chronic pain experienced by people with multiple sclerosis (MS). Researchers will use a detailed clinical assessment to categorize pain as nociceptive, neuropathic, nociplastic, or mixed. The goal is to see if different pain type…

This study investigates whether repetitive transcranial magnetic stimulation (rTMS) can change how the brain processes neuropathic pain—pain from damaged nerves. Researchers will use brain imaging (fMRI) and electrical recordings (EEG) to see how rTMS affects brain activity in pe…

This study is looking at whether two common nerve pain medications, gabapentin and pregabalin, might change inflammation levels or heart function in people with peripheral neuropathic pain. It will follow 75 adults—25 starting gabapentin, 25 starting pregabalin, and 25 healthy co…

This study tracks 400 adults undergoing video-assisted chest surgery (VATS) to see how many develop chronic pain three months later. Researchers will also look for factors like anxiety, depression, and pain intensity that may raise the risk. The goal is to better understand and e…

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study follows 150 adults who had a traumatic arm or leg amputation to see if a stump infection increases the risk of long-term pain. Researchers will check pain levels at 3 and 6 months after surgery. The goal is to understand if preventing infections could reduce chronic pa…

This study looks at 180 adults getting a heart device (like a pacemaker) for the first time. Researchers will track their pain and quality of life for a year, using surveys and a pressure gauge. The goal is to build an AI system that can predict who is at risk for long-term pain,…

This observational study looks at how people with chronic pain experience pleasant touch and how often they encounter it in daily life. Researchers want to see if these experiences are linked to pain sensitivity and body awareness. About 100 adults referred to a pain clinic in Sw…

This study looks at whether negative pressure wound therapy (a machine that helps heal wounds) is linked to ongoing pain six months after a war injury. Researchers will follow 150 adults with severe soft tissue injuries from blasts, bullets, or burns. The goal is to find early si…

This study follows 150 adults with severe arm or leg injuries to see if developing a blood clot raises the risk of long-term pain. Participants are enrolled within 72 hours of hospital admission and monitored for six months. The goal is to understand how blood clots and pain are …

This study looks at whether early ultrasound scans of burn scars can predict which patients will have persistent pain 3 to 6 months later. Researchers will measure scar thickness, blood flow, and nerve involvement in 150 adults with blast or drone-related burns. The goal is to id…

This study follows 100 adults who had a mild to moderate combat-related traumatic brain injury to see who develops long-term pain. Researchers will track pain levels, mental health, and physical factors for 6 months. The goal is to create a tool that can predict chronic pain risk…

This study watches 15 adults with severe cancer pain who are getting a procedure called cordotomy to block pain signals. Researchers will use MRI scans to check for swelling in the spinal cord right after and one month later. The goal is to see if swelling relates to how well the…

This study creates a large international database to monitor how well spinal cord stimulation and similar nerve therapies work for people with chronic nerve pain. Researchers will collect real-world data from 1,000 patients across multiple countries to track safety, quality of li…

This study looks at why some people with type 2 diabetes develop painful nerve damage while others do not. Researchers will measure how the central nervous system processes pain in 128 adults aged 18-80 who have had diabetes for at least one year. The goal is to better understand…