Morbid obesity

This study tests a new, personalized version of a weight-loss surgery called SADI-S. Surgeons will measure each patient's small intestine and adjust the bypass length to maximize weight loss while lowering the risk of vitamin deficiencies. The study includes 40 adults with obesit…

Researchers are studying how the length of bypassed intestine during gastric bypass affects weight loss, complications, and metabolic changes in people with severe obesity. Participants will have different lengths of intestine bypassed and will provide blood and stool samples bef…

This trial tests four different video laryngoscopes to see which one works best for placing a breathing tube in severely obese patients undergoing weight-loss surgery. About 100 adults will take part, and the study will measure how often the tube is placed successfully on the fir…

This study compares an intensive weight loss program—including meal replacements, behavioral support, and weight-loss medication—against standard care for adults with severe and complex obesity. The goal is to see if the intensive approach leads to better health outcomes and is c…

This trial tests whether a newer surgical technique, which combines sleeve gastrectomy with a rerouting of the digestive tract, can control acid reflux as well as the standard gastric bypass in adults with obesity. The new approach aims to keep the entire digestive tract visible …

This pilot trial tests whether tirzepatide, a drug used for diabetes and weight loss, can help people who still have obesity one year after gastric bypass surgery. Thirty participants will either receive the drug or standard care. The study tracks weight changes and any stomach-r…

This early study tests a brain implant that monitors and stimulates brain activity to reduce loss-of-control eating in people with severe obesity who haven't been helped by other treatments. Only 6 participants will receive the device, and the main goal is to check safety and see…

This study tests a new procedure called BEAM (Bariatric Endoscopic Antral Myotomy) to help people with obesity lose weight. The procedure uses a tube down the throat to make small cuts in the stomach muscle, aiming to change how the stomach empties. Twenty adults with a BMI betwe…

This study aimed to see if blocking blood vessels to part of the stomach (bariatric embolization) could help super obese patients lose weight before sleeve gastrectomy surgery, potentially lowering surgical risks. It planned to enroll patients with a BMI over 50 and at least thre…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study tests whether using a connected scale at home can help people who had bariatric surgery avoid regaining too much weight. About 182 adults who had surgery one year ago will either get standard follow-up or also weigh themselves weekly with a smart scale. If the scale sh…

This study tests whether the drug liraglutide, combined with healthy lifestyle changes, can help children aged 6 to 12 with severe obesity lose weight and improve heart function. Thirty children will receive either liraglutide injections plus lifestyle advice or lifestyle advice …

This study tests a new device called the Luso-Cor esophageal stent for closing leaks (fistulas) that can happen after weight-loss or cancer surgery on the stomach or esophagus. About 180 adults will be enrolled and their outcomes compared to those treated with standard stents or …

This study follows 120 teenagers aged 13 to 18 with severe obesity to see if weight-loss surgery (gastric bypass) leads to better health than standard treatments like diet and exercise. Participants are tracked for up to 10 years, measuring weight loss, quality of life, and menta…

This study planned to test a procedure called bariatric embolization for people with morbid obesity who cannot have standard weight-loss surgery. The procedure involves injecting tiny particles into blood vessels near the stomach to reduce blood flow, which may lower hunger hormo…

This study compares two weight loss surgeries for people with severe obesity: sleeve gastrectomy with transit bipartition (SG+TB) and Roux-en-Y gastric bypass (RYGB). About 320 participants will be followed for two years to see which surgery leads to greater weight loss and fewer…

This pilot study is testing whether a procedure called endoscopic sleeve gastroplasty (ESG) is safe and helpful for weight loss in 10 obese adolescents aged 12-17. Instead of traditional weight-loss surgery, doctors use a device inserted through the mouth to stitch the stomach sm…

This study compares two types of weight-loss surgery for people who have already had a sleeve gastrectomy but still have obesity. One surgery is the standard duodenal switch, and the other is a simpler single-loop version. Researchers want to see if the simpler surgery causes few…

This study will follow 5,000 adults who have had endoscopic procedures for weight loss, such as stomach stapling through a scope or gastric balloons. Researchers will track weight, blood pressure, diabetes, and cholesterol for up to 10 years to see how well these procedures work …

This study looks at whether a very-low-calorie ketogenic diet (VLCKD) helps people with severe obesity and metabolic syndrome lose more weight and improve heart health over three years compared to a standard Mediterranean diet. About 100 adults aged 55-75 will be randomly assigne…

This study looks at two ways to manage pain during weight-loss surgery (sleeve gastrectomy) in 70 adults. One group gets standard opioid painkillers, the other gets a mix of non-opioid drugs. The goal is to see if the opioid-free approach can reduce opioid use and still control p…

This study tests an 8-week mindfulness program (MB-EAT) for people who had bariatric surgery at least six months ago and struggle with eating guidelines. About 85 participants will be split into two groups: one gets the mindfulness training, the other does not. Researchers will t…

This study tests a remote program called ReConnect for people who had bariatric surgery about 2 years ago and their romantic partners. The program uses weekly handouts and videos with positive psychology activities to improve mood, resilience, and relationship satisfaction. 82 co…

This study looks at how losing weight affects sexual function and sperm quality in men with severe obesity. About 59 men will either have weight-loss surgery or follow a standard diet plan. Researchers will measure changes in sexual health, hormone levels, and sperm quality to se…

This study looks at whether two types of exercise training can improve body composition, heart and lung function, and quality of life in people who have had bariatric surgery. Researchers will compare high-intensity interval training (HIIT) and moderate-intensity continuous train…

This study tests whether a mix of ketamine and dexmedetomidine (ketodex) can reduce the need for strong painkillers after laparoscopic sleeve gastrectomy in obese patients. Eight adults with a BMI over 35 are randomly assigned to receive either ketodex or standard opioid-based an…

This study compares two types of weight-loss surgery—sleeve gastrectomy alone versus sleeve gastrectomy with transit bipartition—to see which leads to fewer cases of dumping syndrome (nausea, diarrhea, dizziness after eating) and better quality of life. Researchers will follow 20…

This study compares two approaches to help rural adults with obesity lose weight. One method involves quarterly one-on-one visits with a primary care doctor. The other adds a group lifestyle program over Zoom plus quarterly team meetings with the doctor and a lifestyle coach. Res…

This study tests whether a safe green dye, injected during gastric bypass surgery, can help surgeons see blood flow to the new stomach connection. Poor blood flow can lead to ulcers, leaks, or narrowing. The trial involves 300 adults and will follow them for two years to see if u…

Researchers are following 480 adults with severe obesity in Guadeloupe and French Polynesia for five years. The study checks whether having metabolic syndrome, a cluster of conditions like high blood pressure and high blood sugar, raises the risk of chronic kidney disease, heart …

This observational study follows adults with morbid obesity who undergo bariatric surgery to see if substantial weight loss changes the alignment of their hips, knees, and ankles. Researchers measure leg alignment using standing X-rays before surgery and at 3, 6, and 12 months af…

This observational study follows adults with morbid obesity who undergo bariatric surgery to see how substantial weight loss affects the alignment of the spine and pelvis. Researchers measure spinal and pelvic positions on X-rays before surgery and again at 3, 6, and 12 months af…

This study looks at whether routine blood tests taken before weight-loss (bariatric) surgery can help predict who might face complications within 30 days after the operation. Researchers will review medical records of 600 adults who had bariatric surgery, checking levels of certa…

This study looks at how head and neck position (sniffing vs. ramped) and the type of blade used on a video laryngoscope affect how quickly a breathing tube can be placed in 140 severely obese patients (BMI 40 or higher) undergoing elective surgery. The goal is to find the best co…

This study tests whether a swallowable camera capsule, controlled by magnets from outside the body, can safely and effectively examine the stomach and esophagus in 30 people preparing for weight loss surgery. Participants swallow the capsule after fasting, and a surgeon guides it…

This study looks at how changing the length of the small intestine re-routed during gastric bypass surgery affects metabolism and inflammation. Researchers will compare two surgical techniques in 50 people with severe obesity and also include 15 healthy lean individuals as a comp…

This pilot study tests whether liraglutide (Saxenda), a weight-loss drug, can raise levels of a brain-protective protein called BDNF in 30 people with multiple sclerosis, long-COVID, or leukemia who are overweight and have memory or concentration problems. Participants will injec…

This study looks at how weight-loss (bariatric) surgery might change memory and thinking skills in people with obesity who also have cognitive decline. Researchers will test memory and thinking before and after surgery in up to 9,500 participants. The goal is to understand if los…

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study aimed to measure pressure inside the chest (pleural pressure) in people with morbid obesity using a low-dose CT scan and a thin balloon placed in the esophagus. Researchers planned to compare 6 people with a BMI over 40 to 6 people with a BMI under 30. The study was wi…

Researchers are analyzing data from 8,000 patients who had bariatric surgery for severe obesity. The goal is to learn which procedures lead to the best weight loss and health improvements, while also tracking risks like complications and death. This study does not test a new trea…

This study looks at how two types of weight-loss surgery affect bone health in teenagers and young adults aged 13-21. Researchers will measure changes in bone density and strength over two years in 240 participants, comparing those who had surgery with those who did not. The goal…

This study follows 75 people who had either sleeve gastrectomy or gastric bypass for severe obesity. Researchers track acid reflux symptoms, esophageal damage, and other measures for 8 years using tests like endoscopy and pH monitoring. No new treatments are given—it's purely obs…