Morbid obesity

This study will enroll 20 severely obese adults scheduled for metabolic surgery. Half will use a continuous glucose monitor (CGM) and half will use standard finger-stick testing to track blood sugar. Researchers want to see if the CGM leads to steadier blood sugar levels and fewe…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This study tests whether a 28- to 54-week program of weight-loss medication (semaglutide), a hormone-releasing IUD, diet, and exercise is safe and feasible before surgery in women with early endometrial cancer and a BMI of 40 or higher. Eighty participants will be randomly assign…

This study tests whether a specific ventilator mode called APRV can improve breathing and oxygen levels in very obese patients after elective heart surgery. 180 adults with a BMI of 40 or higher (or 35 with related health issues) will be randomly assigned to receive either APRV o…

This study tests whether eating meals at times that match your body's internal clock can help people who have had weight-loss surgery keep the weight off and improve their health. About 246 adults who had sleeve gastrectomy at least six months ago will either follow standard diet…

This study will compare two types of minimally invasive gastric bypass surgery for people with severe obesity: one done with a robot (DaVinci) and the other done by hand (laparoscopy). Researchers want to see which approach leads to fewer complications and is more cost-effective.…

This study tests a special silver-coated mesh placed during emergency abdominal surgery to see if it can prevent surgical site infections and incisional hernias. About 110 adults having urgent open abdominal surgery will take part. Researchers will track infection and hernia rate…

This study looks at whether whole body vibration can improve muscle function, physical fitness, and breathing in people who have had bariatric surgery. Sixty adults who had surgery at least 6 weeks ago will be split into three groups: one does vibration exercises, one does resist…

This study tests whether 12 weeks of daily breathing exercises using a special device can reduce sleep apnea severity and improve sleep quality in 10 adults with severe obesity (BMI over 40) and obstructive sleep apnea. Participants will do progressively harder breathing workouts…

This study tests if placing stitches only in the lower part of the stomach works as well as placing stitches in both the lower and upper parts for weight loss. Ten adults with obesity will get one of the two stitch patterns using a device called Endomina. Researchers will track h…

This study tests whether a single dose of gabapentin, given before weight-loss surgery, can reduce pain and the need for other painkillers in the first 24 hours after the operation. About 102 people having bariatric surgery will receive either gabapentin or a placebo. The goal is…

This study will measure how the body uses energy and burns fat in 10 people with extreme obesity (BMI of 60 or higher). Participants will spend 23 hours in a special metabolic chamber and drink a labeled water to track energy use over a week. The goal is to better understand meta…

Researchers are studying whether three body measurements can help predict how well patients do after one-anastomosis gastric bypass. The measurements are the percentage of a laparoscopic instrument segment covered by fat, the total length of the small bowel, and a calculated abdo…

Researchers want to know whether weight loss from laparoscopic sleeve gastrectomy changes neck pain, posture, and neck function. The study follows about 25 adults scheduled for this weight-loss operation at one hospital. Participants complete neck questionnaires, strength and mot…

This study follows people with severe obesity who are scheduled for bariatric surgery. Researchers will measure changes in body fat, muscle mass, metabolism, and strength before surgery and again at 3 and 6 months after. The goal is to better understand how the surgery affects th…

This study investigates how sleeve gastrectomy, a common weight-loss surgery, impacts brain health and cognitive function in adults with severe obesity. Researchers will use brain scans and thinking tests to measure changes in brain age and mental performance over time. The goal …

This study will follow 100 people with severe obesity who are starting a GLP-1 drug (like Ozempic or Wegovy) to see if it causes new anal or rectal problems within the first 3 months. Participants will have a check-up before starting the drug and again after 3 months to look for …

This study follows 40 adults who recently had laparoscopic sleeve gastrectomy for obesity. Over 6 months, researchers will measure changes in blood sugar, cholesterol, gut barrier markers, and digestive symptoms. The goal is to understand how the surgery affects gut health and me…

This study looks at how inhaled nitric oxide affects oxygen levels and lung function in severely obese patients who have severe breathing failure and are on a ventilator. Researchers will compare these patients to those with normal weight to see if obesity changes how the gas wor…

This study looks at whether a bedside lung ultrasound can help doctors see how well the lungs of obese patients are opening during a breathing machine procedure. The goal is to find the best air pressure to keep lungs open and improve oxygen levels. About 45 adults with a BMI of …

This study will look back at medical records of critically ill trauma patients with severe obesity who needed a breathing tube in the ICU. It aims to compare how often dangerous airway events happen in patients with morbid obesity versus super obesity, and whether higher BMI make…

This study will test two different ways of using a breathing machine (CPAP) in 60 severely obese adults after they wake up from anesthesia. The goal is to see which setting better supports heart and lung function. Participants will be monitored with special sensors to measure lun…

This study looks at whether injecting the blood thinner enoxaparin into the arm or the abdomen works better for preventing blood clots in people with severe obesity (BMI over 40). Researchers will measure drug levels in the blood to see which injection site gives the right amount…