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New ultrasound method could prevent lung injury in obese patients on ventilators

NCT ID NCT07542093

Knowledge-focused Sponsor: Assiut University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a bedside lung ultrasound can help doctors see how well the lungs of obese patients are opening during a breathing machine procedure. The goal is to find the best air pressure to keep lungs open and improve oxygen levels. About 45 adults with a BMI of 33 or higher who need a ventilator will be scanned before, during, and after the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients (aged \>18 years) with morbid obesity (BMI ≥ 33 kg/m²) who are admitted to the respiratory Intensive Care Unit (ICU) at Assiut University Hospital. Patients must be intubated and receiving invasive mechanical ventilation for an expected duration of at least 6 hours, while maintaining hemodynamic stability at enrollment.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged \>18 years * BMI ≥ 33 kg/m² (morbid obesity) * Intubated and receiving invasive mechanical ventilation for any indication (elective surgery, respiratory failure, post-operative ICU admission) * Expected duration of mechanical ventilation ≥ 6 hours * Hemodynamically stable at enrollment: Mean Arterial Pressure (MAP) ≥ 65 mmHg without escalating vasopressor support * SpO₂ ≥ 85% on current ventilator settings * Written informed consent obtained from patient or legal guardian Exclusion Criteria: * Known or suspected pneumothorax or bullous emphysema (contraindication to recruitment maneuvers) * Severe hemodynamic instability: MAP \< 60 mmHg or requiring high-dose vasopressors (norepinephrine \> 0.3 mcg/kg/min) * Active bronchopleural fistula * Recent thoracic or cardiac surgery (within 48 hours) where high airway pressures are contraindicated * Raised intracranial pressure (ICP) or known severe traumatic brain injury * Confirmed ARDS with PaO₂/FiO₂ ratio \< 100 mmHg (severe ARDS, where recruitment strategy differs significantly) * Chest wall deformity or subcutaneous emphysema that precludes reliable lung ultrasound assessment * Refusal of consent

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Conditions

The condition(s) this trial relates to.

middle lobe syndrome morbid obesity Obesity obesity disorder Pulmonary Atelectasis respiratory failure Ventilator-Induced Lung Injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atelectasis Morbid obesity Obesity Respiratory failure Ventilator-induced lung injury (VILI)

How to take part

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  1. The official record

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More trials for these conditions

Other studies related to the condition(s) this trial covers.