New study tests best CPAP settings for obese patients after surgery
NCT ID NCT06287632
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will test two different ways of using a breathing machine (CPAP) in 60 severely obese adults after they wake up from anesthesia. The goal is to see which setting better supports heart and lung function. Participants will be monitored with special sensors to measure lung volume and heart performance.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Continuous positive airway pressure (CPAP) device
- What this could lead to
- If successful, this could help doctors choose the best CPAP settings to protect heart and lung function in severely obese patients after surgery.
- What could go wrong
- This is a small, early-stage study (60 people) that only measures short-term effects. Results may not apply to all patients or lead to changes in care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adult patients (≥ 18 years old) scheduled for elective non-cardiothoracic surgery requiring general anesthesia with an endotracheal tube 2. Planned admission to the post-anesthesia care unit (PACU) after surgery 3. BMI ≥ 40 kg/m2 4. At the time of baseline measurements in the PACU, patients meet the following criteria: * Receiving ≤ 6 liters of supplemental nasal cannula oxygen * Alert as defined by a Richmond Agitation Sedation Scale of 0 or -1 * Oriented to person, place, and time Exclusion Criteria: 1. Pregnancy, suspected pregnancy or less than six weeks postpartum Known or current pneumothorax 2. Hemodynamic instability at the time of study assessment in the PACU defined as: * systolic blood pressure \<90 mmHg or \>180 mmHg * mean blood pressure \<60 or \>130 mmHg * Any use of intravenous vasoactive agent * heart rate \< 50 or \> 120 beats per minute 3. Respiratory insufficiency in PACU defined as: * Respiratory rate \> 30 * Oxygen saturation \< 92% * Receiving \> 6 liters of supplemental oxygen 4. Known chronic lung disease requiring supplemental oxygen at home 5. Known systolic heart dysfunction (left ventricular ejection fraction ≤ 30%) 6. Contraindication for esophageal catheter placement: * Known esophageal varices * Known bacterial sinusitis * Recent esophageal, nasopharyngeal, or laryngeal trauma or surgery * Known coagulopathy: including history of thrombocytopenia defined as platelet count \<50,000; presence of hemophilia; known genetic disorder of coagulation (e.g.,deficits of protein C, protein S, von Willebrand factor) or oral and subcutaneous anticoagulation treatment (e.g., heparin, warfarin, and or other oral anticoagulants) 7. Contraindication for electrical impedance tomograph belt placement: * Pacemaker and/or internal cardiac defibrillator * Chest skin injury 8. Concern for study inclusion by the perioperative nurse or anesthesia team
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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