Lung disorder

This study is testing a new robotic surgery system, the da Vinci SP, for removing part or all of a lung (lobectomy) or the thymus gland (thymectomy) in people with lung cancer, benign lung disease, thymoma, or myasthenia gravis. The goal is to see if the robot can perform these s…

This Phase 2 trial tests an inhaled medication called mosliciguat in 135 people who have both lung scarring (interstitial lung disease) and high blood pressure in the lungs. Participants are randomly assigned to receive either the drug or a placebo for 16 weeks. The study measure…

This phase 2 trial tests a combination of two drugs—ceralasertib (a pill) and durvalumab (an infusion)—in 39 adults with advanced or metastatic non-small cell lung cancer that has worsened after standard treatments like immunotherapy and chemotherapy. The main goal is to see if t…

This Phase 3 trial tests whether hydroxychloroquine, given alone or with azithromycin, can improve outcomes for adults hospitalized with moderate to severe COVID-19 lung disease. Participants receive hydroxychloroquine for 10 days, and some also get azithromycin for 5 days. Resea…

This trial is testing a device called the Aventus Thrombectomy System, which suctions out blood clots from the lungs in people with acute pulmonary embolism. The study involves 130 participants aged 18 to 80. The goal is to see if the device is safe and effective at improving blo…

This study tests whether benralizumab can improve lung structure and function in people with severe eosinophilic asthma who still have symptoms despite standard treatments. About 75 adults aged 18-70 will receive either the drug or a placebo for 48 weeks, followed by a 4-week che…

This study looks at how well the drug osimertinib combined with chemotherapy works as the first treatment for people with advanced EGFR-mutant non-small cell lung cancer. It involves 532 adults with stage IIIB, IIIC, or IV disease who cannot have surgery or radiation. Researchers…

This study tests whether adding the experimental drug zipalertinib to standard chemotherapy works better than chemotherapy alone for people with advanced non-small cell lung cancer that has a specific genetic change (EGFR exon 20 insertion). About 285 adults who have not had prio…

This study tests a new experimental drug, sigvotatug vedotin, against a standard chemotherapy, docetaxel, in people with advanced non-small cell lung cancer that has spread or can't be removed. The goal is to see if the new drug helps people live longer. About 762 adults who have…

This study tests a special virus called a bacteriophage, combined with standard antibiotics, to treat a severe lung infection caused by Mycobacterium abscessus. The trial involves just one patient and aims to see if the virus can help clear the infection. It is an early, personal…

This phase 2 trial tests two drugs, durvalumab and oleclumab, given together after standard chemoradiation in 30 people with stage III lung cancer that cannot be removed by surgery. The goal is to see if the combination can delay cancer progression. Participants must have stable …

This study is for adults with severe asthma who finished the earlier VALIANT trial. It tests the long-term safety and effectiveness of verekitug, a drug given as a shot. About 396 people are taking part. The main goal is to see if verekitug is safe over time and if it can reduce …

This early-phase study tests a new drug called RMC-6291 in adults with advanced cancers (lung, colon, pancreatic) that have a specific KRAS G12C mutation. The goal is to find the safest dose and see how well the drug works. About 222 participants will receive the drug by mouth, a…

This Phase III trial tests whether adding immunotherapy to standard chemotherapy after lung cancer surgery can delay or prevent the cancer from coming back. It enrolls 210 patients with stage IB-IIIA non-small cell lung cancer that was completely removed. Participants are randoml…

This phase 2 trial is testing a combination of two immunotherapy drugs (nivolumab and ipilimumab) plus two cycles of chemotherapy as a first treatment for people with advanced lung cancer that has spread to the brain. The study aims to see if this approach can control the cancer …

This pilot study is testing a wearable device called AeviceMD that lets children with asthma and their caregivers monitor breathing at home. The device sends information to doctors, who can adjust treatment without an office visit. The goal is to see if this helps kids gain bette…

This study tests an oral drug called selpercatinib in people with advanced solid tumors that have RET gene alterations, including certain lung, thyroid, and colon cancers. The goal is to find the best dose and see if the drug can shrink tumors. About 857 participants are enrolled…

This study tests a new medicine, WIN378, for adults with moderate or severe asthma. WIN378 blocks a protein that causes lung inflammation, which may improve asthma control. About 136 participants will receive either WIN378 or a placebo to check safety, how the drug works in the b…

This study tests whether adding a freezing spray (cryospray) to usual treatments can keep narrowed airways open longer in people with benign airway stenosis. About 40 adults will be randomly assigned to get either standard care alone or standard care plus cryospray. The goal is t…

This study was designed to test a special catheter that delivers clot-dissolving medicine directly into the lungs of people with blood clots. The trial was withdrawn before enrolling any participants, so no results are available. It would have included adults aged 18 to 80 with s…

This phase 2 trial tests whether a combination of curcumin (from turmeric) and fish oil can reduce the size of lung nodules in former and current smokers aged 55 and older. Nineteen participants took the supplements or a placebo for 6 months. The study aims to see if the nodules …

This study looks at the long-term safety of the drug ralinepag in people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug remains s…

This study tests an oral drug called selpercatinib (LOXO-292) in children with advanced solid or brain tumors that have a specific RET gene change. The trial has two parts: first finding a safe dose, then measuring how many children's tumors shrink. About 36 children whose cancer…

This program provides taletrectinib, a targeted cancer pill, to adults with advanced or metastatic ROS1-positive non-small cell lung cancer who cannot join a clinical trial or use approved treatments. Patients must have a ROS1 gene fusion and adequate organ function. The goal is …

This study tests a new automated oxygen system for people with chronic lung disease who need oxygen therapy at home. The device automatically adjusts oxygen flow to keep blood oxygen levels in a healthy range. Researchers will compare it to the current fixed-dose method in 25 par…

This study tests a new device (Alterra Prestent) used with a replacement heart valve (SAPIEN 3) to fix a leaky pulmonary valve in people born with heart defects. About 86 participants with moderate or severe leakage will get the device through a tube in a blood vessel, avoiding o…

This study aimed to see if a salmon oil supplement called Cardio® could reduce inflammation and lower heart disease risk in people with chronic obstructive pulmonary disease (COPD). It planned to enroll adults with COPD who smoke or used to smoke. However, the study was withdrawn…

This study tests whether having extra appointments with a heart specialist at a local GP practice helps people get better treatment for heart, kidney, metabolic, and lung conditions. 138 high-risk adults will either receive standard GP care or additional specialist reviews to opt…

This study tests whether stem cells taken from a person's own belly fat can safely help treat chronic lung diseases like COPD. About 100 adults with moderate to severe COPD will receive their own processed cells through an IV. The main goal is to check safety and see if lung func…

This study is testing whether biomarkers found in blood and airway samples can help predict lung cancer in people with suspicious lung nodules. Researchers will collect samples from 85 high-risk smokers and compare them to standard imaging results. The goal is to improve how doct…

This study checks if a lung ultrasound done at the bedside can give clear enough images to help doctors assess patients with shortness of breath. About 150 adults with or without known lung disease will each get two ultrasounds. The goal is to see if the images are good enough fo…

This study looks at whether a bronchodilator (a drug that opens airways) can reduce shortness of breath and improve exercise ability in adults with cystic fibrosis. Twenty participants will receive either the drug or a placebo and then do exercise tests to compare their breathing…

This study compares standard pulmonary rehabilitation exercises to rehabilitation through dance for people with chronic obstructive pulmonary disease (COPD). Forty-four participants will be randomly assigned to either standard rehab or dance-based rehab for 8 weeks. The goal is t…

This study aims to understand how small blood vessels in the lungs change as cystic fibrosis (CF) lung disease progresses. Researchers will use imaging to measure blood vessel volume in 86 people with CF aged 5-21. The goal is to learn more about the disease, not to test a new tr…

Researchers in Uzbekistan are studying common respiratory and heart conditions in children from birth to age 15. They will analyze medical records and examine blood samples to understand immune and antioxidant function in affected children. The goal is to develop and test improve…

This study is building a bio-bank of blood samples from people who have had a lung transplant. Researchers will use these samples to study advanced lung diseases and improve transplant care. The goal is to better understand how infections and other factors affect patient outcomes…

This study looks at whether taking muco-active agents (mucus-thinning drugs like N-acetylcysteine and ambroxol) after a lung cancer diagnosis is linked to better outcomes in people who also have COPD. Researchers will analyze data from a large Korean database, comparing those who…

This study is gathering health information from 4,600 people in rural areas of Alabama, Kentucky, Louisiana, and Mississippi. Researchers will look for risk factors that lead to heart and lung disease. No treatments or drugs are being tested. The goal is to learn more about what …

This study looks at whether educating doctors in small and mid-sized city hospitals can improve how they test and treat patients with advanced non-small cell lung cancer. About 1000 patients will be observed to see if more patients get the right molecular tests and targeted treat…

This study is gathering lung sounds from 750 adults—both healthy volunteers and those with breathing issues—using special digital stethoscopes. The goal is to build an artificial intelligence algorithm that can automatically detect abnormal sounds like wheezes or crackles. If it …

This study is tracking over 1,300 people who are having a lung biopsy or lesion localization with the Ion Endoluminal System, a robotic device. The goal is to see how often the device successfully gets a diagnosis and how often complications like a collapsed lung or bleeding occu…

This study planned to give low-dose chest CT scans to firefighters aged 35 and older to see how many had lung cancer, other cancers, or lung diseases from job-related smoke and chemical exposure. It was withdrawn before any firefighters were enrolled, so no results are available.…

This study is looking for early signs of lung cancer in people at high risk, such as older smokers or those with COPD. Researchers will collect blood and airway samples from 665 participants to find biomarkers that could predict lung cancer before symptoms appear. The goal is to …

This study aimed to see if a non-invasive finger cuff monitor could track heart function in people with a pulmonary embolism (a blood clot in the lung). The device measures stroke volume and cardiac output continuously, which might help doctors detect early signs of heart failure…

This study looks at whether adding special blood tests (biomarkers) to the usual heart-lung exam can help doctors pick the right therapy for people with pulmonary hypertension. About 100 adults undergoing a routine heart catheterization will have extra blood samples taken from th…

This study looks at whether adding the Wim Hof breathing method to a short aerobic workout can improve heart rate, blood pressure, and oxygen use in healthy young adults who smoke. Sixty smokers aged 18 to 25 will be split into two groups: one does only walking or jogging, the ot…

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This study tests whether an educational video can help adults with serious cancer understand and use palliative care. 172 participants will either receive standard care plus brochures, or standard care plus a tailored video and extra materials. Researchers will track knowledge, a…

This study was designed to test a new device called a leak-free bronchoscope adapter. The goal was to see if it could reduce air leaking from the ventilator and limit the spread of aerosols into the operating room during bronchoscopy in intubated patients. The trial was withdrawn…

This study watches 200 people with lung, gut, or hormone diseases over time using special brain scans (PET). It aims to see how these diseases change brain activity and whether those changes can predict tumor return, spread, or survival. No new treatment is tested—just observatio…

This study examines how different genes influence the severity of lung disease in people with cystic fibrosis. Researchers will analyze genetic data from 600 participants to identify gene variants linked to milder or more severe lung problems. The goal is to better understand the…